PLAC1 (placenta enriched 1)

2007-12-01  

Identity

HGNC
PLAC1
LOCATION
Xq26.3
LOCUSID
10761
ALIAS
CT92,OOSP2B,OOSP2L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10761
MIM: 300296
HGNC: 9044
Ensembl: ENSG00000170965

Variants:

dbSNP: 10761
ClinVar: 10761
TCGA: ENSG00000170965
COSMIC: PLAC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170965ENST00000359237Q9HBJ0

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179090632007A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes.35
179832032007PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses.29
181835942008Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients.18
196522262009Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2.16
205091472010PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biology.16
124120442002PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor.15
175548012007Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia.15
158034602005PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis.14
171865542007The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast.13
197058002009Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancer.13

Citation

Dessen P

PLAC1 (placenta enriched 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49881/plac1