PLAC8 (placenta associated 8)

2014-03-01  

Identity

HGNC
PLAC8
LOCATION
4q21.22
LOCUSID
51316
ALIAS
C15,DGIC,PNAS-144,onzin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51316
MIM: 607515
HGNC: 19254
Ensembl: ENSG00000145287

Variants:

dbSNP: 51316
ClinVar: 51316
TCGA: ENSG00000145287
COSMIC: PLAC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145287ENST00000311507Q9NZF1
ENSG00000145287ENST00000311507X2BQ60
ENSG00000145287ENST00000411416Q9NZF1
ENSG00000145287ENST00000411416X2BQ60
ENSG00000145287ENST00000426923Q9NZF1
ENSG00000145287ENST00000426923X2BQ60
ENSG00000145287ENST00000505406Q9NZF1
ENSG00000145287ENST00000505406X2BQ60
ENSG00000145287ENST00000509973D6RA24

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
246914422014Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.44
247944392014Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.26
266698662016PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways.16
200721562010The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation.13
229204402013Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types.13
276435562016Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3β/Wnt/β-catenin signaling.9
297895342018The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth.9
237087102013Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin.8
257203872015Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus.8
300411882018ONZIN Upregulation by Mutant p53 Contributes to Osteosarcoma Metastasis Through the CXCL5-MAPK Signaling Pathway.7

Citation

Dessen P

PLAC8 (placenta associated 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53850/plac8