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PLAC8 (placenta specific 8)

Identity

Alias_symbol (synonym)onzin
C15
Other aliasDGIC
PNAS-144
HGNC (Hugo) PLAC8
LocusID (NCBI) 51316
Atlas_Id 53850
Location 4q21.22  [Link to chromosome band 4q21]
Location_base_pair Starts at 83094154 and ends at 83114758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LOC100507412 (-) / PLAC8 (4q21.22)PLAC8 (4q21.22) / PDS5A (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLAC8   19254
Cards
Entrez_Gene (NCBI)PLAC8  51316  placenta specific 8
AliasesC15; DGIC; PNAS-144; onzin
GeneCards (Weizmann)PLAC8
Ensembl hg19 (Hinxton)ENSG00000145287 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145287 [Gene_View]  chr4:83094154-83114758 [Contig_View]  PLAC8 [Vega]
ICGC DataPortalENSG00000145287
TCGA cBioPortalPLAC8
AceView (NCBI)PLAC8
Genatlas (Paris)PLAC8
WikiGenes51316
SOURCE (Princeton)PLAC8
Genetics Home Reference (NIH)PLAC8
Genomic and cartography
GoldenPath hg38 (UCSC)PLAC8  -     chr4:83094154-83114758 -  4q21.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLAC8  -     4q21.22   [Description]    (hg19-Feb_2009)
EnsemblPLAC8 - 4q21.22 [CytoView hg19]  PLAC8 - 4q21.22 [CytoView hg38]
Mapping of homologs : NCBIPLAC8 [Mapview hg19]  PLAC8 [Mapview hg38]
OMIM607515   
Gene and transcription
Genbank (Entrez)AF208846 AF275812 AF279898 AJ422147 AK000140
RefSeq transcript (Entrez)NM_001130715 NM_001130716 NM_016619
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLAC8
Cluster EST : UnigeneHs.546392 [ NCBI ]
CGAP (NCI)Hs.546392
Alternative Splicing GalleryENSG00000145287
Gene ExpressionPLAC8 [ NCBI-GEO ]   PLAC8 [ EBI - ARRAY_EXPRESS ]   PLAC8 [ SEEK ]   PLAC8 [ MEM ]
Gene Expression Viewer (FireBrowse)PLAC8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51316
GTEX Portal (Tissue expression)PLAC8
Human Protein AtlasENSG00000145287-PLAC8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZF1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZF1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZF1
Splice isoforms : SwissVarQ9NZF1
PhosPhoSitePlusQ9NZF1
Domains : Interpro (EBI)PLAC_motif_containing   
Domain families : Pfam (Sanger)PLAC8 (PF04749)   
Domain families : Pfam (NCBI)pfam04749   
Conserved Domain (NCBI)PLAC8
DMDM Disease mutations51316
Blocks (Seattle)PLAC8
SuperfamilyQ9NZF1
Human Protein Atlas [tissue]ENSG00000145287-PLAC8 [tissue]
Peptide AtlasQ9NZF1
HPRD06335
IPIIPI00410649   IPI00967190   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZF1
IntAct (EBI)Q9NZF1
FunCoupENSG00000145287
BioGRIDPLAC8
STRING (EMBL)PLAC8
ZODIACPLAC8
Ontologies - Pathways
QuickGOQ9NZF1
Ontology : AmiGOchromatin binding  extracellular region  positive regulation of cell proliferation  response to cold  azurophil granule lumen  negative regulation of multicellular organism growth  defense response to bacterium  negative regulation of apoptotic process  neutrophil degranulation  positive regulation of transcription from RNA polymerase II promoter  brown fat cell differentiation  
Ontology : EGO-EBIchromatin binding  extracellular region  positive regulation of cell proliferation  response to cold  azurophil granule lumen  negative regulation of multicellular organism growth  defense response to bacterium  negative regulation of apoptotic process  neutrophil degranulation  positive regulation of transcription from RNA polymerase II promoter  brown fat cell differentiation  
NDEx NetworkPLAC8
Atlas of Cancer Signalling NetworkPLAC8
Wikipedia pathwaysPLAC8
Orthology - Evolution
OrthoDB51316
GeneTree (enSembl)ENSG00000145287
Phylogenetic Trees/Animal Genes : TreeFamPLAC8
HOVERGENQ9NZF1
HOGENOMQ9NZF1
Homologs : HomoloGenePLAC8
Homology/Alignments : Family Browser (UCSC)PLAC8
Gene fusions - Rearrangements
Fusion: Tumor Portal PLAC8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLAC8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLAC8
dbVarPLAC8
ClinVarPLAC8
1000_GenomesPLAC8 
Exome Variant ServerPLAC8
ExAC (Exome Aggregation Consortium)ENSG00000145287
GNOMAD BrowserENSG00000145287
Genetic variants : HAPMAP51316
Genomic Variants (DGV)PLAC8 [DGVbeta]
DECIPHERPLAC8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLAC8 
Mutations
ICGC Data PortalPLAC8 
TCGA Data PortalPLAC8 
Broad Tumor PortalPLAC8
OASIS PortalPLAC8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLAC8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLAC8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLAC8
DgiDB (Drug Gene Interaction Database)PLAC8
DoCM (Curated mutations)PLAC8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLAC8 (select a term)
intoGenPLAC8
Cancer3DPLAC8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607515   
Orphanet
MedgenPLAC8
Genetic Testing Registry PLAC8
NextProtQ9NZF1 [Medical]
TSGene51316
GENETestsPLAC8
Target ValidationPLAC8
Huge Navigator PLAC8 [HugePedia]
snp3D : Map Gene to Disease51316
BioCentury BCIQPLAC8
ClinGenPLAC8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51316
Chemical/Pharm GKB GenePA134950814
Clinical trialPLAC8
Miscellaneous
canSAR (ICR)PLAC8 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLAC8
EVEXPLAC8
GoPubMedPLAC8
iHOPPLAC8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:05:23 CET 2017

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