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LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. |
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A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. |
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ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome. |
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Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis. |
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PMID 16575187 |
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The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. |
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Genomics. 2006 ; 88 (5) : 650-658. |
PMID 16928428 |
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Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation. |
Barz T, Hoffmann A, Panhuysen M, Spengler D |
Cancer research. 2006 ; 66 (24) : 11975-11982. |
PMID 17178896 |
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The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas. |
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Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities. |
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Oncogene. 2001 ; 20 (10) : 1246-1253. |
PMID 11313869 |
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Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells. |
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Brain research. Developmental brain research. 2003 ; 142 (2) : 193-202. |
PMID 12711370 |
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Cyclic AMP-mediated regulation of transcription factor Lot1 expression in cerebellar granule cells. |
Contestabile A, Fila T, Bartesaghi R, Ciani E |
The Journal of biological chemistry. 2005 ; 280 (39) : 33541-33551. |
PMID 16061485 |
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Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. |
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Gynecologic oncology. 2004 ; 95 (3) : 449-455. |
PMID 15581945 |
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Delayed up-regulation of Zac1 and PACAP type I receptor after transient focal cerebral ischemia in mice. |
Gillardon F, Hata R, Hossmann KA |
Brain research. Molecular brain research. 1998 ; 61 (1-2) : 207-210. |
PMID 9795221 |
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The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. |
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Cancer research. 2002 ; 62 (5) : 1510-1517. |
PMID 11888928 |
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Multitasking C2H2 zinc fingers link Zac DNA binding to coordinated regulation of p300-histone acetyltransferase activity. |
Hoffmann A, Barz T, Spengler D |
Molecular and cellular biology. 2006 ; 26 (14) : 5544-5557. |
PMID 16809786 |
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Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. |
Huang SM, Schönthal AH, Stallcup MR |
Oncogene. 2001 ; 20 (17) : 2134-2143. |
PMID 11360197 |
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Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors. |
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Molecular and cellular biology. 2000 ; 20 (5) : 1855-1867. |
PMID 10669760 |
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Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer. |
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The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes. |
Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y |
Human molecular genetics. 2000 ; 9 (3) : 453-460. |
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Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. |
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The Journal of biological chemistry. 1998 ; 273 (36) : 23026-23032. |
PMID 9722527 |
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Loss of expression of ZAC/LOT1 in squamous cell carcinomas of head and neck. |
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Head & neck. 2004 ; 26 (4) : 338-344. |
PMID 15054737 |
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Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. |
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Human genetics. 2002 ; 110 (2) : 139-144. |
PMID 11935319 |
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The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas. |
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Cancer research. 2000 ; 60 (24) : 6794-6799. |
PMID 11156367 |
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Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines. |
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Molecular and cellular biology. 2000 ; 20 (9) : 3308-3315. |
PMID 10757814 |
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The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors. |
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Cancer letters. 2005 ; 227 (2) : 185-191. |
PMID 16112421 |
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The mouse Zac1 locus: basis for imprinting and comparison with human ZAC. |
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PMID 12119104 |
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Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. |
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The EMBO journal. 1997 ; 16 (10) : 2814-2825. |
PMID 9184226 |
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Expression pattern of Zac1 mouse gene, a new zinc-finger protein that regulates apoptosis and cellular cycle arrest, in both adult brain and along development. |
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Mechanisms of development. 2001 ; 108 (1-2) : 207-211. |
PMID 11578877 |
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Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation. |
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Neuroscience. 2004 ; 128 (2) : 323-336. |
PMID 15350644 |
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Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development. |
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Developmental dynamics : an official publication of the American Association of Anatomists. 2005 ; 233 (2) : 667-679. |
PMID 15844099 |
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Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters. |
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Human molecular genetics. 2007 ; 16 (8) : 972-981. |
PMID 17341487 |
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Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. |
Varrault A, Gueydan C, Delalbre A, Bellmann A, Houssami S, Aknin C, Severac D, Chotard L, Kahli M, Le Digarcher A, Pavlidis P, Journot L |
Developmental cell. 2006 ; 11 (5) : 711-722. |
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DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth. |
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Neural development. 2007 ; 2 : page 16. |
PMID 17697379 |
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Physical and functional interactions of human papillomavirus E2 protein with nuclear receptor coactivators. |
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Biochemical and biophysical research communications. 2007 ; 356 (3) : 523-528. |
PMID 17376404 |
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