Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PLAT (plasminogen activator, tissue type)

Identity

Alias_namesplasminogen activator
Other aliasT-PA
TPA
HGNC (Hugo) PLAT
LocusID (NCBI) 5327
Atlas_Id 41739
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 42174718 and ends at 42207724 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AUP1 (2p13.1) / PLAT (8p11.21)CCNJL (5q33.3) / PLAT (8p11.21)ODF2 (9q34.11) / PLAT (8p11.21)
PLAT (8p11.21) / C12orf66 (12q14.2)PLAT 8p11.21 / C12orf66 12q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;12)(p11;q14) PLAT/C12orf66

External links

Nomenclature
HGNC (Hugo)PLAT   9051
LRG (Locus Reference Genomic)LRG_570
Cards
Entrez_Gene (NCBI)PLAT  5327  plasminogen activator, tissue type
AliasesT-PA; TPA
GeneCards (Weizmann)PLAT
Ensembl hg19 (Hinxton)ENSG00000104368 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104368 [Gene_View]  ENSG00000104368 [Sequence]  chr8:42174718-42207724 [Contig_View]  PLAT [Vega]
ICGC DataPortalENSG00000104368
TCGA cBioPortalPLAT
AceView (NCBI)PLAT
Genatlas (Paris)PLAT
WikiGenes5327
SOURCE (Princeton)PLAT
Genetics Home Reference (NIH)PLAT
Genomic and cartography
GoldenPath hg38 (UCSC)PLAT  -     chr8:42174718-42207724 -  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLAT  -     8p11.21   [Description]    (hg19-Feb_2009)
PLAT - 8p11.21 [CytoView hg19]  PLAT - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBIPLAT [Mapview hg19]  PLAT [Mapview hg38]
OMIM173370   612348   
Gene and transcription
Genbank (Entrez)A03776 A07197 AF260825 AF282882 AK289387
RefSeq transcript (Entrez)NM_000930 NM_000931 NM_001319189 NM_033011
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLAT
Cluster EST : UnigeneHs.491582 [ NCBI ]
CGAP (NCI)Hs.491582
Alternative Splicing GalleryENSG00000104368
Gene ExpressionPLAT [ NCBI-GEO ]   PLAT [ EBI - ARRAY_EXPRESS ]   PLAT [ SEEK ]   PLAT [ MEM ]
Gene Expression Viewer (FireBrowse)PLAT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5327
GTEX Portal (Tissue expression)PLAT
Human Protein AtlasENSG00000104368-PLAT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00750
Splice isoforms : SwissVarP00750
Catalytic activity : Enzyme3.4.21.68 [ Enzyme-Expasy ]   3.4.21.683.4.21.68 [ IntEnz-EBI ]   3.4.21.68 [ BRENDA ]   3.4.21.68 [ KEGG ]   
PhosPhoSitePlusP00750
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    FN1_1 (PS01253)    FN1_2 (PS51091)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Fibronectin_type1    Kringle    Kringle-like    Kringle_CS    Kringle_sf    Peptidase_S1_PA    Peptidase_S1A    Tissue_plasm_act    tPA    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    fn1 (PF00039)    Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00039    pfam00051    pfam00089   
Domain families : Smart (EMBL)FN1 (SM00058)  KR (SM00130)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PLAT
DMDM Disease mutations5327
Blocks (Seattle)PLAT
PDB (RSDB)1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
PDB Europe1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
PDB (PDBSum)1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
PDB (IMB)1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
Structural Biology KnowledgeBase1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
SCOP (Structural Classification of Proteins)1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
CATH (Classification of proteins structures)1A5H    1BDA    1PK2    1PML    1RTF    1TPG    1TPK    1TPM    1TPN    5BRR   
SuperfamilyP00750
Human Protein Atlas [tissue]ENSG00000104368-PLAT [tissue]
Peptide AtlasP00750
HPRD01419
IPIIPI00019590   IPI00479511   IPI00295285   IPI00981191   IPI00910450   IPI00911063   IPI00980016   IPI00980639   
Protein Interaction databases
DIP (DOE-UCLA)P00750
IntAct (EBI)P00750
FunCoupENSG00000104368
BioGRIDPLAT
STRING (EMBL)PLAT
ZODIACPLAT
Ontologies - Pathways
QuickGOP00750
Ontology : AmiGOresponse to hypoxia  serine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  signaling receptor binding  protein binding  protein binding  extracellular region  extracellular space  cytoplasm  cellular protein modification process  proteolysis  blood coagulation  cell surface  smooth muscle cell migration  secretory granule  plasminogen activation  plasminogen activation  fibrinolysis  apical part of cell  negative regulation of proteolysis  platelet-derived growth factor receptor signaling pathway  phosphoprotein binding  collagen-containing extracellular matrix  extracellular exosome  Schaffer collateral - CA1 synapse  glutamatergic synapse  trans-synaptic signaling by BDNF, modulating synaptic transmission  
Ontology : EGO-EBIresponse to hypoxia  serine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  signaling receptor binding  protein binding  protein binding  extracellular region  extracellular space  cytoplasm  cellular protein modification process  proteolysis  blood coagulation  cell surface  smooth muscle cell migration  secretory granule  plasminogen activation  plasminogen activation  fibrinolysis  apical part of cell  negative regulation of proteolysis  platelet-derived growth factor receptor signaling pathway  phosphoprotein binding  collagen-containing extracellular matrix  extracellular exosome  Schaffer collateral - CA1 synapse  glutamatergic synapse  trans-synaptic signaling by BDNF, modulating synaptic transmission  
Pathways : KEGGComplement and coagulation cascades    Transcriptional misregulation in cancer   
NDEx NetworkPLAT
Atlas of Cancer Signalling NetworkPLAT
Wikipedia pathwaysPLAT
Orthology - Evolution
OrthoDB5327
GeneTree (enSembl)ENSG00000104368
Phylogenetic Trees/Animal Genes : TreeFamPLAT
HOGENOMP00750
Homologs : HomoloGenePLAT
Homology/Alignments : Family Browser (UCSC)PLAT
Gene fusions - Rearrangements
Fusion : MitelmanPLAT/C12orf66 [8p11.21/12q14.2]  
Fusion PortalPLAT 8p11.21 C12orf66 12q14.2 SKCM
Fusion : QuiverPLAT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLAT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLAT
dbVarPLAT
ClinVarPLAT
1000_GenomesPLAT 
Exome Variant ServerPLAT
ExAC (Exome Aggregation Consortium)ENSG00000104368
GNOMAD BrowserENSG00000104368
Varsome BrowserPLAT
Genetic variants : HAPMAP5327
Genomic Variants (DGV)PLAT [DGVbeta]
DECIPHERPLAT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLAT 
Mutations
ICGC Data PortalPLAT 
TCGA Data PortalPLAT 
Broad Tumor PortalPLAT
OASIS PortalPLAT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLAT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLAT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLAT
DgiDB (Drug Gene Interaction Database)PLAT
DoCM (Curated mutations)PLAT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLAT (select a term)
intoGenPLAT
Cancer3DPLAT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173370    612348   
Orphanet
DisGeNETPLAT
MedgenPLAT
Genetic Testing Registry PLAT
NextProtP00750 [Medical]
TSGene5327
GENETestsPLAT
Target ValidationPLAT
Huge Navigator PLAT [HugePedia]
snp3D : Map Gene to Disease5327
BioCentury BCIQPLAT
ClinGenPLAT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5327
Chemical/Pharm GKB GenePA33381
Clinical trialPLAT
Miscellaneous
canSAR (ICR)PLAT (select the gene name)
DataMed IndexPLAT
Probes
Litterature
PubMed353 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLAT
EVEXPLAT
GoPubMedPLAT
iHOPPLAT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu May 2 13:04:39 CEST 2019
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