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PLAU (plasminogen activator, urokinase)

Identity

Alias_symbol (synonym)URK
UPA
Other aliasATF
BDPLT5
QPD
u-PA
HGNC (Hugo) PLAU
LocusID (NCBI) 5328
Atlas_Id 41740
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 75670859 and ends at 75677258 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLAU   9052
LRG (Locus Reference Genomic)LRG_593
Cards
Entrez_Gene (NCBI)PLAU  5328  plasminogen activator, urokinase
AliasesATF; BDPLT5; QPD; UPA; 
URK; u-PA
GeneCards (Weizmann)PLAU
Ensembl hg19 (Hinxton)ENSG00000122861 [Gene_View]  chr10:75670859-75677258 [Contig_View]  PLAU [Vega]
Ensembl hg38 (Hinxton)ENSG00000122861 [Gene_View]  chr10:75670859-75677258 [Contig_View]  PLAU [Vega]
ICGC DataPortalENSG00000122861
TCGA cBioPortalPLAU
AceView (NCBI)PLAU
Genatlas (Paris)PLAU
WikiGenes5328
SOURCE (Princeton)PLAU
Genetics Home Reference (NIH)PLAU
Genomic and cartography
GoldenPath hg19 (UCSC)PLAU  -     chr10:75670859-75677258 +  10q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLAU  -     10q22.2   [Description]    (hg38-Dec_2013)
EnsemblPLAU - 10q22.2 [CytoView hg19]  PLAU - 10q22.2 [CytoView hg38]
Mapping of homologs : NCBIPLAU [Mapview hg19]  PLAU [Mapview hg38]
OMIM104300   191840   601709   
Gene and transcription
Genbank (Entrez)A18397 A35395 AB208961 AK297940 AK298560
RefSeq transcript (Entrez)NM_001145031 NM_001319191 NM_002658
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_011904 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)PLAU
Cluster EST : UnigeneHs.77274 [ NCBI ]
CGAP (NCI)Hs.77274
Alternative Splicing GalleryENSG00000122861
Gene ExpressionPLAU [ NCBI-GEO ]   PLAU [ EBI - ARRAY_EXPRESS ]   PLAU [ SEEK ]   PLAU [ MEM ]
Gene Expression Viewer (FireBrowse)PLAU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5328
GTEX Portal (Tissue expression)PLAU
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00749
Splice isoforms : SwissVarP00749
Catalytic activity : Enzyme3.4.21.73 [ Enzyme-Expasy ]   3.4.21.733.4.21.73 [ IntEnz-EBI ]   3.4.21.73 [ BRENDA ]   3.4.21.73 [ KEGG ]   
PhosPhoSitePlusP00749
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_3 (PS50026)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Kringle    Kringle-like    Kringle_CS    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00051    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  KR (SM00130)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PLAU
DMDM Disease mutations5328
Blocks (Seattle)PLAU
PDB (SRS)1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
PDB (PDBSum)1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
PDB (IMB)1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
PDB (RSDB)1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
Structural Biology KnowledgeBase1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
SCOP (Structural Classification of Proteins)1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
CATH (Classification of proteins structures)1C5W    1C5X    1C5Y    1C5Z    1EJN    1F5K    1F5L    1F92    1FV9    1GI7    1GI8    1GI9    1GJ7    1GJ8    1GJ9    1GJA    1GJB    1GJC    1GJD    1KDU    1LMW    1O3P    1O5A    1O5B    1O5C    1OWD    1OWE    1OWH    1OWI    1OWJ    1OWK    1SC8    1SQA    1SQO    1SQT    1U6Q    1URK    1VJ9    1VJA    1W0Z    1W10    1W11    1W12    1W13    1W14    2FD6    2I9A    2I9B    2NWN    2O8T    2O8U    2O8W    2R2W    2VIN    2VIO    2VIP    2VIQ    2VIV    2VIW    2VNT    3BT1    3BT2    3IG6    3KGP    3KHV    3KID    3M61    3MHW    3MWI    3OX7    3OY5    3OY6    3PB1    3QN7    3U73    4DVA    4DW2    4FU7    4FU8    4FU9    4FUB    4FUC    4FUD    4FUE    4FUF    4FUG    4FUH    4FUI    4FUJ    4GLY    4H42    4JK5    4JK6    4JNI    4JNL    4K24    4MNV    4MNW    4MNX    4MNY    4OS1    4OS2    4OS4    4OS5    4OS6    4OS7    4X0W    4X1N    4X1P    4X1Q    4X1R    4X1S    4XSK    4ZHL    4ZHM   
SuperfamilyP00749
Human Protein AtlasENSG00000122861
Peptide AtlasP00749
HPRD01883
IPIIPI00296180   IPI00645018   IPI01013717   
Protein Interaction databases
DIP (DOE-UCLA)P00749
IntAct (EBI)P00749
FunCoupENSG00000122861
BioGRIDPLAU
STRING (EMBL)PLAU
ZODIACPLAU
Ontologies - Pathways
QuickGOP00749
Ontology : AmiGOangiogenesis  serine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  plasma membrane  focal adhesion  proteolysis  chemotaxis  signal transduction  spermatogenesis  embryo implantation  blood coagulation  positive regulation of cell proliferation  cell surface  regulation of receptor activity  response to activity  smooth muscle cell migration  regulation of smooth muscle cell migration  positive regulation of smooth muscle cell migration  regulation of cell adhesion mediated by integrin  cellular response to hepatocyte growth factor stimulus  fibrinolysis  skeletal muscle tissue regeneration  response to hyperoxia  positive regulation of ovulation  regulation of wound healing  extracellular exosome  neuron death  cellular response to lipopolysaccharide  cellular response to glucose stimulus  cellular response to hypoxia  cellular response to fluid shear stress  cellular response to staurosporine  regulation of smooth muscle cell-matrix adhesion  regulation of hepatocyte proliferation  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIangiogenesis  serine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  plasma membrane  focal adhesion  proteolysis  chemotaxis  signal transduction  spermatogenesis  embryo implantation  blood coagulation  positive regulation of cell proliferation  cell surface  regulation of receptor activity  response to activity  smooth muscle cell migration  regulation of smooth muscle cell migration  positive regulation of smooth muscle cell migration  regulation of cell adhesion mediated by integrin  cellular response to hepatocyte growth factor stimulus  fibrinolysis  skeletal muscle tissue regeneration  response to hyperoxia  positive regulation of ovulation  regulation of wound healing  extracellular exosome  neuron death  cellular response to lipopolysaccharide  cellular response to glucose stimulus  cellular response to hypoxia  cellular response to fluid shear stress  cellular response to staurosporine  regulation of smooth muscle cell-matrix adhesion  regulation of hepatocyte proliferation  positive regulation of reactive oxygen species metabolic process  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]    Platelet Amyloid Precursor Protein Pathway [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Complement and coagulation cascades    Transcriptional misregulation in cancer    Proteoglycans in cancer    MicroRNAs in cancer   
NDEx NetworkPLAU
Atlas of Cancer Signalling NetworkPLAU
Wikipedia pathwaysPLAU
Orthology - Evolution
OrthoDB5328
GeneTree (enSembl)ENSG00000122861
Phylogenetic Trees/Animal Genes : TreeFamPLAU
HOVERGENP00749
HOGENOMP00749
Homologs : HomoloGenePLAU
Homology/Alignments : Family Browser (UCSC)PLAU
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLAU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLAU
dbVarPLAU
ClinVarPLAU
1000_GenomesPLAU 
Exome Variant ServerPLAU
ExAC (Exome Aggregation Consortium)PLAU (select the gene name)
Genetic variants : HAPMAP5328
Genomic Variants (DGV)PLAU [DGVbeta]
DECIPHER (Syndromes)10:75670859-75677258  ENSG00000122861
CONAN: Copy Number AnalysisPLAU 
Mutations
ICGC Data PortalPLAU 
TCGA Data PortalPLAU 
Broad Tumor PortalPLAU
OASIS PortalPLAU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLAU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLAU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLAU
DgiDB (Drug Gene Interaction Database)PLAU
DoCM (Curated mutations)PLAU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLAU (select a term)
intoGenPLAU
Cancer3DPLAU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104300    191840    601709   
Orphanet18908   
MedgenPLAU
Genetic Testing Registry PLAU
NextProtP00749 [Medical]
TSGene5328
GENETestsPLAU
Huge Navigator PLAU [HugePedia]
snp3D : Map Gene to Disease5328
BioCentury BCIQPLAU
ClinGenPLAU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5328
Chemical/Pharm GKB GenePA33382
Clinical trialPLAU
Miscellaneous
canSAR (ICR)PLAU (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLAU
EVEXPLAU
GoPubMedPLAU
iHOPPLAU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:36 CEST 2017

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