Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLAU (plasminogen activator, urokinase)

Identity

Alias_symbol (synonym)URK
UPA
Other aliasATF
BDPLT5
QPD
u-PA
HGNC (Hugo) PLAU
LocusID (NCBI) 5328
Atlas_Id 41740
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 73911101 and ends at 73917500 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLAU   9052
LRG (Locus Reference Genomic)LRG_593
Cards
Entrez_Gene (NCBI)PLAU  5328  plasminogen activator, urokinase
AliasesATF; BDPLT5; QPD; UPA; 
URK; u-PA
GeneCards (Weizmann)PLAU
Ensembl hg19 (Hinxton)ENSG00000122861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122861 [Gene_View]  chr10:73911101-73917500 [Contig_View]  PLAU [Vega]
ICGC DataPortalENSG00000122861
TCGA cBioPortalPLAU
AceView (NCBI)PLAU
Genatlas (Paris)PLAU
WikiGenes5328
SOURCE (Princeton)PLAU
Genetics Home Reference (NIH)PLAU
Genomic and cartography
GoldenPath hg38 (UCSC)PLAU  -     chr10:73911101-73917500 +  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLAU  -     10q22.2   [Description]    (hg19-Feb_2009)
EnsemblPLAU - 10q22.2 [CytoView hg19]  PLAU - 10q22.2 [CytoView hg38]
Mapping of homologs : NCBIPLAU [Mapview hg19]  PLAU [Mapview hg38]
OMIM104300   191840   601709   
Gene and transcription
Genbank (Entrez)A18397 A35395 AB208961 AH007073 AK297940
RefSeq transcript (Entrez)NM_001145031 NM_001319191 NM_002658
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLAU
Cluster EST : UnigeneHs.77274 [ NCBI ]
CGAP (NCI)Hs.77274
Alternative Splicing GalleryENSG00000122861
Gene ExpressionPLAU [ NCBI-GEO ]   PLAU [ EBI - ARRAY_EXPRESS ]   PLAU [ SEEK ]   PLAU [ MEM ]
Gene Expression Viewer (FireBrowse)PLAU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5328
GTEX Portal (Tissue expression)PLAU
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00749
Splice isoforms : SwissVarP00749
Catalytic activity : Enzyme3.4.21.73 [ Enzyme-Expasy ]   3.4.21.733.4.21.73 [ IntEnz-EBI ]   3.4.21.73 [ BRENDA ]   3.4.21.73 [ KEGG ]   
PhosPhoSitePlusP00749
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_3 (PS50026)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Kringle    Kringle-like    Kringle_CS    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00051    pfam00089   
Domain families : Smart (EMBL)KR (SM00130)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)PLAU
DMDM Disease mutations5328
Blocks (Seattle)PLAU
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP00749
Human Protein AtlasENSG00000122861
Peptide AtlasP00749
HPRD01883
IPIIPI00296180   IPI00645018   IPI01013717   
Protein Interaction databases
DIP (DOE-UCLA)P00749
IntAct (EBI)P00749
FunCoupENSG00000122861
BioGRIDPLAU
STRING (EMBL)PLAU
ZODIACPLAU
Ontologies - Pathways
QuickGOP00749
Ontology : AmiGOresponse to hypoxia  serine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  plasma membrane  focal adhesion  proteolysis  chemotaxis  signal transduction  blood coagulation  cell surface  regulation of receptor activity  smooth muscle cell migration  regulation of smooth muscle cell migration  positive regulation of cell migration  plasminogen activation  regulation of cell adhesion mediated by integrin  specific granule membrane  regulation of cell proliferation  fibrinolysis  neutrophil degranulation  regulation of wound healing  extracellular exosome  tertiary granule membrane  regulation of smooth muscle cell-matrix adhesion  
Ontology : EGO-EBIresponse to hypoxia  serine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  plasma membrane  focal adhesion  proteolysis  chemotaxis  signal transduction  blood coagulation  cell surface  regulation of receptor activity  smooth muscle cell migration  regulation of smooth muscle cell migration  positive regulation of cell migration  plasminogen activation  regulation of cell adhesion mediated by integrin  specific granule membrane  regulation of cell proliferation  fibrinolysis  neutrophil degranulation  regulation of wound healing  extracellular exosome  tertiary granule membrane  regulation of smooth muscle cell-matrix adhesion  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]    Platelet Amyloid Precursor Protein Pathway [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Complement and coagulation cascades    Transcriptional misregulation in cancer    Proteoglycans in cancer    MicroRNAs in cancer   
NDEx NetworkPLAU
Atlas of Cancer Signalling NetworkPLAU
Wikipedia pathwaysPLAU
Orthology - Evolution
OrthoDB5328
GeneTree (enSembl)ENSG00000122861
Phylogenetic Trees/Animal Genes : TreeFamPLAU
HOVERGENP00749
HOGENOMP00749
Homologs : HomoloGenePLAU
Homology/Alignments : Family Browser (UCSC)PLAU
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLAU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLAU
dbVarPLAU
ClinVarPLAU
1000_GenomesPLAU 
Exome Variant ServerPLAU
ExAC (Exome Aggregation Consortium)PLAU (select the gene name)
Genetic variants : HAPMAP5328
Genomic Variants (DGV)PLAU [DGVbeta]
DECIPHERPLAU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLAU 
Mutations
ICGC Data PortalPLAU 
TCGA Data PortalPLAU 
Broad Tumor PortalPLAU
OASIS PortalPLAU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLAU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLAU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLAU
DgiDB (Drug Gene Interaction Database)PLAU
DoCM (Curated mutations)PLAU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLAU (select a term)
intoGenPLAU
Cancer3DPLAU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104300    191840    601709   
Orphanet18908   
MedgenPLAU
Genetic Testing Registry PLAU
NextProtP00749 [Medical]
TSGene5328
GENETestsPLAU
Target ValidationPLAU
Huge Navigator PLAU [HugePedia]
snp3D : Map Gene to Disease5328
BioCentury BCIQPLAU
ClinGenPLAU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5328
Chemical/Pharm GKB GenePA33382
Clinical trialPLAU
Miscellaneous
canSAR (ICR)PLAU (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLAU
EVEXPLAU
GoPubMedPLAU
iHOPPLAU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:49:45 CEST 2017

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