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PLB1 (phospholipase B1)

Identity

Alias_symbol (synonym)PLB
FLJ30866
Other aliasPLB/LIP
HGNC (Hugo) PLB1
LocusID (NCBI) 151056
Atlas_Id 71961
Location 2p23.2  [Link to chromosome band 2p23]
Location_base_pair Starts at 28496071 and ends at 28643787 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FOXN2 (2p16.3) / PLB1 (2p23.2)LTBP1 (2p22.3) / PLB1 (2p23.2)PLB1 (2p23.2) / BRE (2p23.2)
PLB1 (2p23.2) / CAB39 (2q37.1)PPP1CB (2p23.2) / PLB1 (2p23.2)LTBP1 PLB1
PPP1CB PLB1FOXN2 PLB1PLB1 BRE
PLB1 CAB39

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLB1   30041
Cards
Entrez_Gene (NCBI)PLB1  151056  phospholipase B1
AliasesPLB; PLB/LIP
GeneCards (Weizmann)PLB1
Ensembl hg19 (Hinxton)ENSG00000163803 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163803 [Gene_View]  chr2:28496071-28643787 [Contig_View]  PLB1 [Vega]
ICGC DataPortalENSG00000163803
TCGA cBioPortalPLB1
AceView (NCBI)PLB1
Genatlas (Paris)PLB1
WikiGenes151056
SOURCE (Princeton)PLB1
<` href=../extdef.html#GHR TARGET=GHR>Genetics Home Reference (NIH)PLB1
Genomic and cartography
GoldenPath hg38 (UCSC)PLB1  -     chr2:28496071-28643787 +  2p23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLB1  -     2p23.2   [Description]    (hg19-Feb_2009)
EnsemblPLB1 - 2p23.2 [CytoView hg19]  PLB1 - 2p23.2 [CytoView hg38]
Mapping of homologs : NCBIPLB1 [Mapview hg19]  PLB1 [Mapview hg38]
OMIM610179   
Gene and transcription
Genbank (Entrez)AK055428 BC042674 BC065041 BC150633 BC153864
RefSeq transcript (Entrez)NM_001170585 NM_153021
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLB1
Cluster EST : UnigeneHs.444933 [ NCBI ]
CGAP (NCI)Hs.444933
Alternative Splicing GalleryENSG00000163803
Gene ExpressionPLB1 [ NCBI-GEO ]   PLB1 [ EBI - ARRAY_EXPRESS ]   PLB1 [ SEEK ]   PLB1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151056
GTEX Portal (Tissue expression)PLB1
Human Protein AtlasENSG00000163803-PLB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P1J6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P1J6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P1J6
Splice isoforms : SwissVarQ6P1J6
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusQ6P1J6
Domaine pattern : Prosite (Expaxy)LIPASE_GDSL_SER (PS01098)   
Domains : Interpro (EBI)GDSL    Lipase_GDSL_AS    SGNH_hydro   
Domain families : Pfam (Sanger)Lipase_GDSL (PF00657)   
Domain families : Pfam (NCBI)pfam00657   
Conserved Domain (NCBI)PLB1
DMDM Disease mutations151056
Blocks (Seattle)PLB1
SuperfamilyQ6P1J6
Human Protein Atlas [tissue]ENSG00000163803-PLB1 [tissue]
Peptide AtlasQ6P1J6
HPRD15141
IPIIPI00397878   IPI00478604   IPI00886740   IPI00888210   IPI00888960   IPI00893994   IPI00893599   IPI01014734   IPI00893341   
Protein Interaction databases
DIP (DOE-UCLA)Q6P1J6
IntAct (EBI)Q6P1J6
FunCoupENSG00000163803
BioGRIDPLB1
STRING (EMBL)PLB1
ZODIACPLB1
Ontologies - Pathways
QuickGOQ6P1J6
Ontology : AmiGOretinoid metabolic process  lysophospholipase activity  phospholipase A2 activity  plasma membrane  integral component of membrane  lipid catabolic process  apical plasma membrane  phosphatidylcholine acyl-chain remodeling  retinol metabolic process  retinyl-palmitate esterase activity  positive regulation of acrosome reaction  
Ontology : EGO-EBIretinoid metabolic process  lysophospholipase activity  phospholipase A2 activity  plasma membrane  integral component of membrane  lipid catabolic process  apical plasma membrane  phosphatidylcholine acyl-chain remodeling  retinol metabolic process  retinyl-palmitate esterase activity  positive regulation of acrosome reaction  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    Vitamin digestion and absorption   
NDEx NetworkPLB1
Atlas of Cancer Signalling NetworkPLB1
Wikipedia pathwaysPLB1
Orthology - Evolution
OrthoDB151056
GeneTree (enSembl)ENSG00000163803
Phylogenetic Trees/Animal Genes : TreeFamPLB1
HOVERGENQ6P1J6
HOGENOMQ6P1J6
Homologs : HomoloGenePLB1
Homology/Alignments : Family Browser (UCSC)PLB1
Gene fusions - Rearrangements
Fusion: TCGALTBP1 PLB1
Fusion: TCGAPPP1CB PLB1
Fusion: TCGAFOXN2 PLB1
Fusion: TCGAPLB1 BRE
Fusion: TCGAPLB1 CAB39
Fusion: Tumor Portal PLB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLB1
dbVarPLB1
ClinVarPLB1
1000_GenomesPLB1 
Exome Variant ServerPLB1
ExAC (Exome Aggregation Consortium)ENSG00000163803
GNOMAD BrowserENSG00000163803
Genetic variants : HAPMAP151056
Genomic Variants (DGV)PLB1 [DGVbeta]
DECIPHERPLB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLB1 
Mutations
ICGC Data PortalPLB1 
TCGA Data PortalPLB1 
Broad Tumor PortalPLB1
OASIS PortalPLB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLB1
DgiDB (Drug Gene Interaction Database)PLB1
DoCM (Curated mutations)PLB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLB1 (select a term)
intoGenPLB1
Cancer3DPLB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610179   
Orphanet
MedgenPLB1
Genetic Testing Registry PLB1
NextProtQ6P1J6 [Medical]
TSGene151056
GENETestsPLB1
Target ValidationPLB1
Huge Navigator PLB1 [HugePedia]
snp3D : Map Gene to Disease151056
BioCentury BCIQPLB1
ClinGenPLB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD151056
Chemical/Pharm GKB GenePA134891309
Clinical trialPLB1
Miscellaneous
canSAR (ICR)PLB1 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLB1
EVEXPLB1
GoPubMedPLB1
iHOPPLB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:22:44 CET 2017

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