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PLCB3 (phospholipase C beta 3)

Identity

Alias_namesphospholipase C
Other alias-
HGNC (Hugo) PLCB3
LocusID (NCBI) 5331
Atlas_Id 41744
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64251523 and ends at 64269452 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLCB3 (11q13.1) / BAD (11q13.1)PLCB3 (11q13.1) / DGCR14 (22q11.21)PLCB3 (11q13.1) / FAM65A (16q22.1)
PLCB3 (11q13.1) / VEGFB (11q13.1)PLCB3 11q13.1 / BAD 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCB3   9056
Cards
Entrez_Gene (NCBI)PLCB3  5331  phospholipase C beta 3
Aliases
GeneCards (Weizmann)PLCB3
Ensembl hg19 (Hinxton)ENSG00000149782 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149782 [Gene_View]  chr11:64251523-64269452 [Contig_View]  PLCB3 [Vega]
ICGC DataPortalENSG00000149782
TCGA cBioPortalPLCB3
AceView (NCBI)PLCB3
Genatlas (Paris)PLCB3
WikiGenes5331
SOURCE (Princeton)PLCB3
Genetics Home Reference (NIH)PLCB3
Genomic and cartography
GoldenPath hg38 (UCSC)PLCB3  -     chr11:64251523-64269452 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLCB3  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblPLCB3 - 11q13.1 [CytoView hg19]  PLCB3 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIPLCB3 [Mapview hg19]  PLCB3 [Mapview hg38]
OMIM600230   
Gene and transcription
Genbank (Entrez)AB385031 BC032659 BC041625 BC142681 BC146645
RefSeq transcript (Entrez)NM_000932 NM_001184883 NM_001316314
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLCB3
Cluster EST : UnigeneHs.523761 [ NCBI ]
CGAP (NCI)Hs.523761
Alternative Splicing GalleryENSG00000149782
Gene ExpressionPLCB3 [ NCBI-GEO ]   PLCB3 [ EBI - ARRAY_EXPRESS ]   PLCB3 [ SEEK ]   PLCB3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5331
GTEX Portal (Tissue expression)PLCB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01970   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01970
Splice isoforms : SwissVarQ01970
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
PhosPhoSitePlusQ01970
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    PH_dom-like    PI-PLC_fam    PLC-beta    PLC-beta3    PLC-beta_C    PLC-like_Pdiesterase_TIM-brl    PLC_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)    PLC-beta_C (PF08703)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam00388    pfam00387    pfam08703   
Domain families : Smart (EMBL)C2 (SM00239)  PLCXc (SM00148)  PLCYc (SM00149)  
Conserved Domain (NCBI)PLCB3
DMDM Disease mutations5331
Blocks (Seattle)PLCB3
PDB (SRS)3OHM    4GNK    4QJ3    4QJ4    4QJ5   
PDB (PDBSum)3OHM    4GNK    4QJ3    4QJ4    4QJ5   
PDB (IMB)3OHM    4GNK    4QJ3    4QJ4    4QJ5   
PDB (RSDB)3OHM    4GNK    4QJ3    4QJ4    4QJ5   
Structural Biology KnowledgeBase3OHM    4GNK    4QJ3    4QJ4    4QJ5   
SCOP (Structural Classification of Proteins)3OHM    4GNK    4QJ3    4QJ4    4QJ5   
CATH (Classification of proteins structures)3OHM    4GNK    4QJ3    4QJ4    4QJ5   
SuperfamilyQ01970
Human Protein AtlasENSG00000149782
Peptide AtlasQ01970
HPRD02577
IPIIPI00010400   IPI00181283   
Protein Interaction databases
DIP (DOE-UCLA)Q01970
IntAct (EBI)Q01970
FunCoupENSG00000149782
BioGRIDPLCB3
STRING (EMBL)PLCB3
ZODIACPLCB3
Ontologies - Pathways
QuickGOQ01970
Ontology : AmiGOregulation of systemic arterial blood pressure  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  calcium ion binding  calmodulin binding  nucleoplasm  cytosol  Wnt signaling pathway, calcium modulating pathway  chemical synaptic transmission  membrane  lipid catabolic process  intracellular signal transduction  protein complex  inositol phosphate metabolic process  cadherin binding  
Ontology : EGO-EBIregulation of systemic arterial blood pressure  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  calcium ion binding  calmodulin binding  nucleoplasm  cytosol  Wnt signaling pathway, calcium modulating pathway  chemical synaptic transmission  membrane  lipid catabolic process  intracellular signal transduction  protein complex  inositol phosphate metabolic process  cadherin binding  
Pathways : KEGG   
NDEx NetworkPLCB3
Atlas of Cancer Signalling NetworkPLCB3
Wikipedia pathwaysPLCB3
Orthology - Evolution
OrthoDB5331
GeneTree (enSembl)ENSG00000149782
Phylogenetic Trees/Animal Genes : TreeFamPLCB3
HOVERGENQ01970
HOGENOMQ01970
Homologs : HomoloGenePLCB3
Homology/Alignments : Family Browser (UCSC)PLCB3
Gene fusions - Rearrangements
Fusion : MitelmanPLCB3/BAD [11q13.1/11q13.1]  
Fusion: TCGAPLCB3 11q13.1 BAD 11q13.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLCB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCB3
dbVarPLCB3
ClinVarPLCB3
1000_GenomesPLCB3 
Exome Variant ServerPLCB3
ExAC (Exome Aggregation Consortium)PLCB3 (select the gene name)
Genetic variants : HAPMAP5331
Genomic Variants (DGV)PLCB3 [DGVbeta]
DECIPHERPLCB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLCB3 
Mutations
ICGC Data PortalPLCB3 
TCGA Data PortalPLCB3 
Broad Tumor PortalPLCB3
OASIS PortalPLCB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLCB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLCB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLCB3
DgiDB (Drug Gene Interaction Database)PLCB3
DoCM (Curated mutations)PLCB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCB3 (select a term)
intoGenPLCB3
Cancer3DPLCB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600230   
Orphanet
MedgenPLCB3
Genetic Testing Registry PLCB3
NextProtQ01970 [Medical]
TSGene5331
GENETestsPLCB3
Target ValidationPLCB3
Huge Navigator PLCB3 [HugePedia]
snp3D : Map Gene to Disease5331
BioCentury BCIQPLCB3
ClinGenPLCB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5331
Chemical/Pharm GKB GenePA33386
Clinical trialPLCB3
Miscellaneous
canSAR (ICR)PLCB3 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCB3
EVEXPLCB3
GoPubMedPLCB3
iHOPPLCB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:49:45 CEST 2017

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