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PLCB4 (phospholipase C, beta 4)

Identity

Other namesARCND2
PI-PLC
HGNC (Hugo) PLCB4
LocusID (NCBI) 5332
Location 20p12.2
Location_base_pair Starts at 9288447 and ends at 9461462 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLCB4   9059
Cards
Entrez_Gene (NCBI)PLCB4  5332  phospholipase C, beta 4
GeneCards (Weizmann)PLCB4
Ensembl (Hinxton)ENSG00000101333 [Gene_View]  chr20:9288447-9461462 [Contig_View]  PLCB4 [Vega]
ICGC DataPortalENSG00000101333
AceView (NCBI)PLCB4
Genatlas (Paris)PLCB4
WikiGenes5332
SOURCE (Princeton)NM_000933 NM_001172646 NM_182797
Genomic and cartography
GoldenPath (UCSC)PLCB4  -  20p12.2   chr20:9288447-9461462 +  20p12.2   [Description]    (hg19-Feb_2009)
EnsemblPLCB4 - 20p12.2 [CytoView]
Mapping of homologs : NCBIPLCB4 [Mapview]
OMIM600810   614669   
Gene and transcription
Genbank (Entrez)AK025027 AK054754 AK057634 AK122699 AK307482
RefSeq transcript (Entrez)NM_000933 NM_001172646 NM_182797
RefSeq genomic (Entrez)AC_000152 NC_000020 NC_018931 NG_032790 NT_011387 NW_001838652 NW_004929416
Consensus coding sequences : CCDS (NCBI)PLCB4
Cluster EST : UnigeneHs.472101 [ NCBI ]
CGAP (NCI)Hs.472101
Alternative Splicing : Fast-db (Paris)GSHG0018562
Alternative Splicing GalleryENSG00000101333
Gene ExpressionPLCB4 [ NCBI-GEO ]     PLCB4 [ SEEK ]   PLCB4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15147 (Uniprot)
NextProtQ15147  [Medical]
With graphics : InterProQ15147
Splice isoforms : SwissVarQ15147 (Swissvar)
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    PH_like_dom    PI-PLC_fam    PLC-beta    PLC-beta_CS    PLC-like_Pdiesterase_TIM-brl    PLipase_C_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Related proteins : CluSTrQ15147
Domain families : Pfam (Sanger)C2 (PF00168)    DUF1154 (PF06631)    EF-hand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)   
Domain families : Pfam (NCBI)pfam00168    pfam06631    pfam09279    pfam00388    pfam00387   
Domain families : Smart (EMBL)C2 (SM00239)  PLCXc (SM00148)  PLCYc (SM00149)  
DMDM Disease mutations5332
Blocks (Seattle)Q15147
Human Protein AtlasENSG00000101333
Peptide AtlasQ15147
HPRD02885
IPIIPI00014897   IPI00883983   IPI00783004   IPI00827781   IPI00643180   IPI00640067   IPI00646955   IPI00643106   
Protein Interaction databases
DIP (DOE-UCLA)Q15147
IntAct (EBI)Q15147
FunCoupENSG00000101333
BioGRIDPLCB4
InParanoidQ15147
Interologous Interaction database Q15147
IntegromeDBPLCB4
STRING (EMBL)PLCB4
Ontologies - Pathways
Ontology : AmiGOphosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  calcium ion binding  nucleus  smooth endoplasmic reticulum  cytosol  postsynaptic density  lipid catabolic process  dendrite  intracellular signal transduction  inositol phosphate metabolic process  small molecule metabolic process  
Ontology : EGO-EBIphosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  calcium ion binding  nucleus  smooth endoplasmic reticulum  cytosol  postsynaptic density  lipid catabolic process  dendrite  intracellular signal transduction  inositol phosphate metabolic process  small molecule metabolic process  
Pathways : KEGGInositol phosphate metabolism    Rap1 signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Phosphatidylinositol signaling system    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Wnt signaling pathway    Gap junction    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    Dopaminergic synapse    Long-term depression    Insulin secretion    GnRH signaling pathway    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Thyroid hormone signaling pathway    Endocrine and other factor-regulated calcium reabsorption    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Alzheimer's disease    Huntington's disease    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Amoebiasis   
Protein Interaction DatabasePLCB4
Wikipedia pathwaysPLCB4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PLCB4
SNP (GeneSNP Utah)PLCB4
SNP : HGBasePLCB4
Genetic variants : HAPMAPPLCB4
1000_GenomesPLCB4 
ICGC programENSG00000101333 
CONAN: Copy Number AnalysisPLCB4 
Somatic Mutations in Cancer : COSMICPLCB4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDPLCB4
OMIM600810    614669   
MedgenPLCB4
GENETestsPLCB4
Disease Genetic AssociationPLCB4
Huge Navigator PLCB4 [HugePedia]  PLCB4 [HugeCancerGEM]
Genomic VariantsPLCB4  PLCB4 [DGVbeta]
Exome VariantPLCB4
dbVarPLCB4
ClinVarPLCB4
snp3D : Map Gene to Disease5332
General knowledge
Homologs : HomoloGenePLCB4
Homology/Alignments : Family Browser (UCSC)PLCB4
Phylogenetic Trees/Animal Genes : TreeFamPLCB4
Chemical/Protein Interactions : CTD5332
Chemical/Pharm GKB GenePA33387
Clinical trialPLCB4
Cancer Resource (Charite)ENSG00000101333
Other databases
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
CoreMinePLCB4
iHOPPLCB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:08:38 CEST 2014

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