PLCD3 (phospholipase C delta 3)

2007-04-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
PLC-delta-3
FUSION GENES

Other Information

Locus ID:

NCBI: 113026
MIM: 608795
HGNC: 9061
Ensembl: ENSG00000161714

Variants:

dbSNP: 113026
ClinVar: 113026
TCGA: ENSG00000161714
COSMIC: PLCD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161714ENST00000538093F5GXC1
ENSG00000161714ENST00000539433H0YGF8
ENSG00000161714ENST00000590644K7EQF2
ENSG00000161714ENST00000619929Q8N3E9

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Calcium signaling pathwayKEGGko04020
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Calcium signaling pathwayKEGGhsa04020
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
Thyroid hormone signaling pathwayKEGGhsa04919
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA26097CASRGenePathwayassociated
PA33759PRKCAGenePathwayassociated
PA33761PRKCBGenePathwayassociated
PA33766PRKCGGenePathwayassociated
PA33767PRKCHGenePathwayassociated
PA33768PRKCIGenePathwayassociated
PA33771PRKD1GenePathwayassociated
PA33775PRKCZGenePathwayassociated
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD22525200
PA449334diltiazemChemicalClinicalAnnotationassociatedPD22525200

References

Pubmed IDYearTitleCitations
194304832009Genome-wide association study identifies eight loci associated with blood pressure.476
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
208524452011Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.24
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
193446322009Expression and function of phospholipase C in breast carcinoma.9
200561782010Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.5
239484862013Physiological functions of phospholipase Cδ1 and phospholipase Cδ3.4
193293422009Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study.3
227239642012Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.3
291155282018PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.3

Citation

Dessen P

PLCD3 (phospholipase C delta 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47013/plcd3