Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PLCD3 (phospholipase C delta 3)

Identity

Alias_namesphospholipase C
Other aliasPLC-delta-3
HGNC (Hugo) PLCD3
LocusID (NCBI) 113026
Atlas_Id 47013
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 45111640 and ends at 45132533 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DCAKD (17q21.31) / PLCD3 (17q21.31)EFTUD2 (17q21.31) / PLCD3 (17q21.31)PLCD3 (17q21.31) / SNRPF (12q23.1)
PLCD3 (17q21.31) / TYK2 (19p13.2)DCAKD 17q21.31 / PLCD3 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCD3   9061
Cards
Entrez_Gene (NCBI)PLCD3  113026  phospholipase C delta 3
AliasesPLC-delta-3
GeneCards (Weizmann)PLCD3
Ensembl hg19 (Hinxton)ENSG00000161714 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161714 [Gene_View]  chr17:45111640-45132533 [Contig_View]  PLCD3 [Vega]
ICGC DataPortalENSG00000161714
TCGA cBioPortalPLCD3
AceView (NCBI)PLCD3
Genatlas (Paris)PLCD3
WikiGenes113026
SOURCE (Princeton)PLCD3
Genetics Home Reference (NIH)PLCD3
Genomic and cartography
GoldenPath hg38 (UCSC)PLCD3  -     chr17:45111640-45132533 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLCD3  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblPLCD3 - 17q21.31 [CytoView hg19]  PLCD3 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIPLCD3 [Mapview hg19]  PLCD3 [Mapview hg38]
OMIM608795   
Gene and transcription
Genbank (Entrez)AB075844 AK074240 AL834392 BC010668 BC072384
RefSeq transcript (Entrez)NM_133373
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLCD3
Cluster EST : UnigeneHs.380094 [ NCBI ]
CGAP (NCI)Hs.380094
Alternative Splicing GalleryENSG00000161714
Gene ExpressionPLCD3 [ NCBI-GEO ]   PLCD3 [ EBI - ARRAY_EXPRESS ]   PLCD3 [ SEEK ]   PLCD3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)113026
GTEX Portal (Tissue expression)PLCD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3E9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3E9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3E9
Splice isoforms : SwissVarQ8N3E9
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
PhosPhoSitePlusQ8N3E9
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    EF_HAND_1 (PS00018)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    EF_Hand_1_Ca_BS    PH_dom-like    PH_domain    PI-PLC_fam    PLC-delta3    PLC-like_Pdiesterase_TIM-brl    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Domain families : Pfam (Sanger)C2 (PF00168)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)   
Domain families : Pfam (NCBI)pfam00168    pfam00388    pfam00387   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  
Conserved Domain (NCBI)PLCD3
DMDM Disease mutations113026
Blocks (Seattle)PLCD3
SuperfamilyQ8N3E9
Human Protein AtlasENSG00000161714
Peptide AtlasQ8N3E9
HPRD07146
IPIIPI00152701   IPI01015849   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3E9
IntAct (EBI)Q8N3E9
FunCoupENSG00000161714
BioGRIDPLCD3
STRING (EMBL)PLCD3
ZODIACPLCD3
Ontologies - Pathways
QuickGOQ8N3E9
Ontology : AmiGOangiogenesis  phosphatidylinositol phospholipase C activity  signal transducer activity  cytosol  plasma membrane  lipid catabolic process  cleavage furrow  intracellular signal transduction  regulation of cell proliferation  inositol phosphate metabolic process  metal ion binding  labyrinthine layer blood vessel development  
Ontology : EGO-EBIangiogenesis  phosphatidylinositol phospholipase C activity  signal transducer activity  cytosol  plasma membrane  lipid catabolic process  cleavage furrow  intracellular signal transduction  regulation of cell proliferation  inositol phosphate metabolic process  metal ion binding  labyrinthine layer blood vessel development  
Pathways : KEGGInositol phosphate metabolism    Calcium signaling pathway    Phosphatidylinositol signaling system    Thyroid hormone signaling pathway   
NDEx NetworkPLCD3
Atlas of Cancer Signalling NetworkPLCD3
Wikipedia pathwaysPLCD3
Orthology - Evolution
OrthoDB113026
GeneTree (enSembl)ENSG00000161714
Phylogenetic Trees/Animal Genes : TreeFamPLCD3
HOVERGENQ8N3E9
HOGENOMQ8N3E9
Homologs : HomoloGenePLCD3
Homology/Alignments : Family Browser (UCSC)PLCD3
Gene fusions - Rearrangements
Fusion : MitelmanDCAKD/PLCD3 [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion: TCGADCAKD 17q21.31 PLCD3 17q21.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLCD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCD3
dbVarPLCD3
ClinVarPLCD3
1000_GenomesPLCD3 
Exome Variant ServerPLCD3
ExAC (Exome Aggregation Consortium)PLCD3 (select the gene name)
Genetic variants : HAPMAP113026
Genomic Variants (DGV)PLCD3 [DGVbeta]
DECIPHERPLCD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLCD3 
Mutations
ICGC Data PortalPLCD3 
TCGA Data PortalPLCD3 
Broad Tumor PortalPLCD3
OASIS PortalPLCD3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLCD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLCD3
DgiDB (Drug Gene Interaction Database)PLCD3
DoCM (Curated mutations)PLCD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCD3 (select a term)
intoGenPLCD3
Cancer3DPLCD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608795   
Orphanet
MedgenPLCD3
Genetic Testing Registry PLCD3
NextProtQ8N3E9 [Medical]
TSGene113026
GENETestsPLCD3
Target ValidationPLCD3
Huge Navigator PLCD3 [HugePedia]
snp3D : Map Gene to Disease113026
BioCentury BCIQPLCD3
ClinGenPLCD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD113026
Chemical/Pharm GKB GenePA33389
Clinical trialPLCD3
Miscellaneous
canSAR (ICR)PLCD3 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCD3
EVEXPLCD3
GoPubMedPLCD3
iHOPPLCD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:25:07 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.