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PLCD4 (phospholipase C delta 4)

Identity

Alias_namesphospholipase C
Other alias-
HGNC (Hugo) PLCD4
LocusID (NCBI) 84812
Atlas_Id 47280
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218607765 and ends at 218637186 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARF1 (1q42.13) / PLCD4 (2q35)PLCD4 (2q35) / MARC2 (1q41)PLCD4 (2q35) / VIL1 (2q35)
SEPT10 (2q13) / PLCD4 (2q35)XXYLT1 (3q29) / PLCD4 (2q35)PLCD4 2q35 / VIL1 2q35
SEPT10 2q13 / PLCD4 2q35

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCD4   9062
Cards
Entrez_Gene (NCBI)PLCD4  84812  phospholipase C delta 4
Aliases
GeneCards (Weizmann)PLCD4
Ensembl hg19 (Hinxton)ENSG00000115556 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115556 [Gene_View]  ENSG00000115556 [Sequence]  chr2:218607765-218637186 [Contig_View]  PLCD4 [Vega]
ICGC DataPortalENSG00000115556
TCGA cBioPortalPLCD4
AceView (NCBI)PLCD4
Genatlas (Paris)PLCD4
WikiGenes84812
SOURCE (Princeton)PLCD4
Genetics Home Reference (NIH)PLCD4
Genomic and cartography
GoldenPath hg38 (UCSC)PLCD4  -     chr2:218607765-218637186 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLCD4  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblPLCD4 - 2q35 [CytoView hg19]  PLCD4 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIPLCD4 [Mapview hg19]  PLCD4 [Mapview hg38]
OMIM605939   
Gene and transcription
Genbank (Entrez)AB209599 AI914254 AK023083 AK057186 AK223203
RefSeq transcript (Entrez)NM_032726
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLCD4
Cluster EST : UnigeneHs.632528 [ NCBI ]
CGAP (NCI)Hs.632528
Alternative Splicing GalleryENSG00000115556
Gene ExpressionPLCD4 [ NCBI-GEO ]   PLCD4 [ EBI - ARRAY_EXPRESS ]   PLCD4 [ SEEK ]   PLCD4 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84812
GTEX Portal (Tissue expression)PLCD4
Human Protein AtlasENSG00000115556-PLCD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRC7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRC7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRC7
Splice isoforms : SwissVarQ9BRC7
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
PhosPhoSitePlusQ9BRC7
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    C2_domain_sf    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    PH-like_dom_sf    PH_domain    PI-PLC_fam    PLC-delta4    PLC-like_Pdiesterase_TIM-brl    PLC_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_5 (PF13202)    EF-hand_like (PF09279)    PH (PF00169)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)   
Domain families : Pfam (NCBI)pfam00168    pfam13202    pfam09279    pfam00169    pfam00388    pfam00387   
Domain families : Smart (EMBL)C2 (SM00239)  EFh (SM00054)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  
Conserved Domain (NCBI)PLCD4
DMDM Disease mutations84812
Blocks (Seattle)PLCD4
SuperfamilyQ9BRC7
Human Protein Atlas [tissue]ENSG00000115556-PLCD4 [tissue]
Peptide AtlasQ9BRC7
HPRD07296
IPIIPI00013745   IPI00867639   IPI00910329   IPI01015054   IPI00953268   IPI00556239   IPI00927498   IPI00924643   IPI00925060   IPI00925245   
Protein Interaction databases
DIP (DOE-UCLA)Q9BRC7
IntAct (EBI)Q9BRC7
FunCoupENSG00000115556
BioGRIDPLCD4
STRING (EMBL)PLCD4
ZODIACPLCD4
Ontologies - Pathways
QuickGOQ9BRC7
Ontology : AmiGOphosphatidylinositol phospholipase C activity  phosphatidylinositol phospholipase C activity  calcium ion binding  endoplasmic reticulum membrane  cytosol  plasma membrane  acrosome reaction  lipid catabolic process  nuclear membrane  intracellular signal transduction  inositol phosphate metabolic process  phosphatidylinositol metabolic process  
Ontology : EGO-EBIphosphatidylinositol phospholipase C activity  phosphatidylinositol phospholipase C activity  calcium ion binding  endoplasmic reticulum membrane  cytosol  plasma membrane  acrosome reaction  lipid catabolic process  nuclear membrane  intracellular signal transduction  inositol phosphate metabolic process  phosphatidylinositol metabolic process  
Pathways : KEGGInositol phosphate metabolism    Calcium signaling pathway    Phosphatidylinositol signaling system    Thyroid hormone signaling pathway   
NDEx NetworkPLCD4
Atlas of Cancer Signalling NetworkPLCD4
Wikipedia pathwaysPLCD4
Orthology - Evolution
OrthoDB84812
GeneTree (enSembl)ENSG00000115556
Phylogenetic Trees/Animal Genes : TreeFamPLCD4
HOVERGENQ9BRC7
HOGENOMQ9BRC7
Homologs : HomoloGenePLCD4
Homology/Alignments : Family Browser (UCSC)PLCD4
Gene fusions - Rearrangements
Fusion PortalPLCD4 2q35 VIL1 2q35 BRCA
Fusion PortalSEPT10 2q13 PLCD4 2q35 LGG
Fusion : QuiverPLCD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLCD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCD4
dbVarPLCD4
ClinVarPLCD4
1000_GenomesPLCD4 
Exome Variant ServerPLCD4
ExAC (Exome Aggregation Consortium)ENSG00000115556
GNOMAD BrowserENSG00000115556
Varsome BrowserPLCD4
Genetic variants : HAPMAP84812
Genomic Variants (DGV)PLCD4 [DGVbeta]
DECIPHERPLCD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLCD4 
Mutations
ICGC Data PortalPLCD4 
TCGA Data PortalPLCD4 
Broad Tumor PortalPLCD4
OASIS PortalPLCD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLCD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLCD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLCD4
DgiDB (Drug Gene Interaction Database)PLCD4
DoCM (Curated mutations)PLCD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCD4 (select a term)
intoGenPLCD4
Cancer3DPLCD4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605939   
Orphanet
DisGeNETPLCD4
MedgenPLCD4
Genetic Testing Registry PLCD4
NextProtQ9BRC7 [Medical]
TSGene84812
GENETestsPLCD4
Target ValidationPLCD4
Huge Navigator PLCD4 [HugePedia]
snp3D : Map Gene to Disease84812
BioCentury BCIQPLCD4
ClinGenPLCD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84812
Chemical/Pharm GKB GenePA33390
Clinical trialPLCD4
Miscellaneous
canSAR (ICR)PLCD4 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCD4
EVEXPLCD4
GoPubMedPLCD4
iHOPPLCD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:30:27 CET 2018

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