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PLCG2 (phospholipase C gamma 2)

Identity

Other namesAPLAID
FCAS3
PLC-IV
PLC-gamma-2
HGNC (Hugo) PLCG2
LocusID (NCBI) 5336
Atlas_Id 41745
Location 16q23.3
Location_base_pair Starts at 81812863 and ends at 81996298 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CYFIP2 (5q33.3) / PLCG2 (16q23.3)PLCG2 (16q23.3) / RN7SK ()PLCG2 (16q23.3) / WWOX (16q23.1)
PLCG2 16q23.3 / WWOX 16q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCG2   9066
Cards
Entrez_Gene (NCBI)PLCG2  5336  phospholipase C gamma 2
AliasesAPLAID; FCAS3; PLC-IV; PLC-gamma-2
GeneCards (Weizmann)PLCG2
Ensembl hg19 (Hinxton)ENSG00000197943 [Gene_View]  chr16:81812863-81996298 [Contig_View]  PLCG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197943 [Gene_View]  chr16:81812863-81996298 [Contig_View]  PLCG2 [Vega]
ICGC DataPortalENSG00000197943
TCGA cBioPortalPLCG2
AceView (NCBI)PLCG2
Genatlas (Paris)PLCG2
WikiGenes5336
SOURCE (Princeton)PLCG2
Genomic and cartography
GoldenPath hg19 (UCSC)PLCG2  -     chr16:81812863-81996298 +  16q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLCG2  -     16q23.3   [Description]    (hg38-Dec_2013)
EnsemblPLCG2 - 16q23.3 [CytoView hg19]  PLCG2 - 16q23.3 [CytoView hg38]
Mapping of homologs : NCBIPLCG2 [Mapview hg19]  PLCG2 [Mapview hg38]
OMIM600220   614468   614878   
Gene and transcription
Genbank (Entrez)AB208914 AK127374 AK304722 AK310042 AW504432
RefSeq transcript (Entrez)NM_002661
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_032019 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)PLCG2
Cluster EST : UnigeneHs.586906 [ NCBI ]
CGAP (NCI)Hs.586906
Alternative Splicing GalleryENSG00000197943
Gene ExpressionPLCG2 [ NCBI-GEO ]   PLCG2 [ EBI - ARRAY_EXPRESS ]   PLCG2 [ SEEK ]   PLCG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5336
GTEX Portal (Tissue expression)PLCG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16885 (Uniprot)
NextProtP16885  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16885
Splice isoforms : SwissVarP16885 (Swissvar)
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
PhosPhoSitePlusP16885
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    PH_dom-like    PH_domain    PI-PLC_fam    PLC-gamma    PLC-gamma2    PLC-like_Pdiesterase_TIM-brl    PLC_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y    SH2    SH3_domain   
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam00388    pfam00387    pfam00017    pfam00018   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  SH2 (SM00252)  SH3 (SM00326)  
DMDM Disease mutations5336
Blocks (Seattle)PLCG2
PDB (SRS)2K2J    2W2W    2W2X   
PDB (PDBSum)2K2J    2W2W    2W2X   
PDB (IMB)2K2J    2W2W    2W2X   
PDB (RSDB)2K2J    2W2W    2W2X   
Structural Biology KnowledgeBase2K2J    2W2W    2W2X   
SCOP (Structural Classification of Proteins)2K2J    2W2W    2W2X   
CATH (Classification of proteins structures)2K2J    2W2W    2W2X   
SuperfamilyP16885
Human Protein AtlasENSG00000197943
Peptide AtlasP16885
HPRD02570
IPIIPI00329185   
Protein Interaction databases
DIP (DOE-UCLA)P16885
IntAct (EBI)P16885
FunCoupENSG00000197943
BioGRIDPLCG2
STRING (EMBL)PLCG2
ZODIACPLCG2
Ontologies - Pathways
QuickGOP16885
Ontology : AmiGOpositive regulation of receptor internalization  stimulatory C-type lectin receptor signaling pathway  follicular B cell differentiation  phosphatidylinositol phospholipase C activity  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  protein binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol biosynthetic process  phospholipid catabolic process  regulation of gene expression  Wnt signaling pathway  calcium-mediated signaling  platelet activation  B cell differentiation  activation of store-operated calcium channel activity  positive regulation of type I interferon production  response to lipopolysaccharide  inositol trisphosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  negative regulation of programmed cell death  inositol phosphate metabolic process  T cell receptor signaling pathway  B cell receptor signaling pathway  release of sequestered calcium ion into cytosol  extracellular exosome  
Ontology : EGO-EBIpositive regulation of receptor internalization  stimulatory C-type lectin receptor signaling pathway  follicular B cell differentiation  phosphatidylinositol phospholipase C activity  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  protein binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol biosynthetic process  phospholipid catabolic process  regulation of gene expression  Wnt signaling pathway  calcium-mediated signaling  platelet activation  B cell differentiation  activation of store-operated calcium channel activity  positive regulation of type I interferon production  response to lipopolysaccharide  inositol trisphosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  negative regulation of programmed cell death  inositol phosphate metabolic process  T cell receptor signaling pathway  B cell receptor signaling pathway  release of sequestered calcium ion into cytosol  extracellular exosome  
Pathways : KEGGInositol phosphate metabolism    ErbB signaling pathway    Ras signaling pathway    Calcium signaling pathway    NF-kappa B signaling pathway    HIF-1 signaling pathway    Phosphatidylinositol signaling system    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Neurotrophin signaling pathway    Thyroid hormone signaling pathway    Vibrio cholerae infection    Epithelial cell signaling in Helicobacter pylori infection    Epstein-Barr virus infection    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Glioma    Non-small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkPLCG2
Wikipedia pathwaysPLCG2
Orthology - Evolution
OrthoDB5336
GeneTree (enSembl)ENSG00000197943
Phylogenetic Trees/Animal Genes : TreeFamPLCG2
Homologs : HomoloGenePLCG2
Homology/Alignments : Family Browser (UCSC)PLCG2
Gene fusions - Rearrangements
Fusion: TCGAPLCG2 16q23.3 WWOX 16q23.1 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerPLCG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCG2
dbVarPLCG2
ClinVarPLCG2
1000_GenomesPLCG2 
Exome Variant ServerPLCG2
ExAC (Exome Aggregation Consortium)PLCG2 (select the gene name)
Genetic variants : HAPMAP5336
Genomic Variants (DGV)PLCG2 [DGVbeta]
Mutations
ICGC Data PortalPLCG2 
TCGA Data PortalPLCG2 
Broad Tumor PortalPLCG2
OASIS PortalPLCG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLCG2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch PLCG2
DgiDB (Drug Gene Interaction Database)PLCG2
DoCM (Curated mutations)PLCG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCG2 (select a term)
intoGenPLCG2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:81812863-81996298  ENSG00000197943
CONAN: Copy Number AnalysisPLCG2 
Mutations and Diseases : HGMDPLCG2
OMIM600220    614468    614878   
MedgenPLCG2
Genetic Testing Registry PLCG2
NextProtP16885 [Medical]
TSGene5336
GENETestsPLCG2
Huge Navigator PLCG2 [HugePedia]
snp3D : Map Gene to Disease5336
BioCentury BCIQPLCG2
ClinGenPLCG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5336
Chemical/Pharm GKB GenePA33393
Clinical trialPLCG2
Miscellaneous
canSAR (ICR)PLCG2 (select the gene name)
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCG2
EVEXPLCG2
GoPubMedPLCG2
iHOPPLCG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:16:02 CEST 2016

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