Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PLCG2 (phospholipase C, gamma 2 (phosphatidylinositol-specific))

Identity

Other namesAPLAID
FCAS3
HGNC (Hugo) PLCG2
LocusID (NCBI) 5336
Location 16q23.3
Location_base_pair Starts at 81812899 and ends at 81991899 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLCG2   9066
Entrez_Gene (NCBI)PLCG2  5336  phospholipase C, gamma 2 (phosphatidylinositol-specific)
Cards
GeneCards (Weizmann)PLCG2
Ensembl (Hinxton)ENSG00000197943 [Gene_View]  chr16:81812899-81991899 [Contig_View]  PLCG2 [Vega]
AceView (NCBI)PLCG2
Genatlas (Paris)PLCG2
SOURCE (Stanford)NM_002661
Genomic and cartography
GoldenPath (UCSC)PLCG2  -  16q23.3   chr16:81812899-81991899 +  16q23.3   [Description]    (hg19-Feb_2009)
EnsemblPLCG2 - 16q23.3 [CytoView]
Mapping of homologs : NCBIPLCG2 [Mapview]
OMIM600220   614468   614878   
Gene and transcription
Genbank (Entrez)AB208914 AK304722 AK310042 AW504432 AY364256
RefSeq transcript (SRS)NM_002661
RefSeq transcript (Entrez)NM_002661
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NG_032019 NT_010498 NW_001838328 NW_004078087
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_032019 NT_010498 NW_001838328 NW_004078087
Consensus coding sequences : CCDS (NCBI)PLCG2
Cluster EST : UnigeneHs.413111 [ SRS ] Hs.413111 [ NCBI ]
CGAP (NCI)Hs.413111
Alternative Splicing : Fast-db (Paris)GSHG0011394
Alternative Splicing GalleryENSG00000197943
Gene ExpressionPLCG2 [ NCBI-GEO ]   PLCG2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16885 (SRS) P16885 (Uniprot)
NextProtP16885
With graphics : InterProP16885
Splice isoforms : SwissVarP16885(Swissvar)
Domaine pattern : Prosite (SRS)C2 (PS50004)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)    SH2 (PS50001)    SH3 (PS50002)   
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (SRS)C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_membr_targeting    PH_like_dom    Pinositol_PLipase_C    PLC-gamma    PLC-like_Pdiesterase_TIM-brl    Pleckstrin_homology    PLipase_C_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y    SH2    SH3_domain   
Domains : Interpro (EBI)C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_membr_targeting    PH_like_dom    Pinositol_PLipase_C    PLC-gamma    PLC-like_Pdiesterase_TIM-brl    Pleckstrin_homology    PLipase_C_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y    SH2    SH3_domain   
Related proteins : CluSTrP16885
Domain families : Pfam (SRS)C2 (PF00168)    efhand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (Sanger)C2 (PF00168)    efhand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam00388    pfam00387    pfam00017    pfam00018   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  SH2 (SM00252)  SH3 (SM00326)  
DMDM5336
Blocks (Seattle)P16885
PDB (SRS)2K2J    2W2W    2W2X   
PDB (PDBSum)2K2J    2W2W    2W2X   
PDB (IMB)2K2J    2W2W    2W2X   
PDB (RSDB)2K2J    2W2W    2W2X   
Human Protein AtlasENSG00000197943
HPRD02570
IPIIPI00329185   
Protein Interaction databases
DIP (DOE-UCLA)P16885
IntAct (EBI)P16885
FunCoupENSG00000197943
REACTOMEPLCG2
Protein Interaction Database5336
BioGRIDPLCG2
InParanoidP16885
Interologous Interaction database P16885
IntegromeDBPLCG2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PLCG2
SNP (GeneSNP Utah)PLCG2
SNP : HGBasePLCG2
Genetic variants : HAPMAPPLCG2
Somatic Mutations in Cancer : COSMICPLCG2 
CONAN: Copy Number AnalysisPLCG2 
Mutations and Diseases : HGMDPLCG2
OMIM600220    614468    614878   
GENETests600220    614468    614878   
Disease Genetic AssociationPLCG2
Huge Navigator PLCG2 [HugePedia]  PLCG2 [HugeCancerGEM]
Genomic VariantsPLCG2  PLCG2 [DGVbeta]
snp3D : Map Gene to Disease5336
General knowledge
Homologs : HomoloGenePLCG2
Homology/Alignments : Family Browser (UCSC)PLCG2
Phylogenetic Trees/Animal Genes : TreeFamPLCG2
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.11 [ Enzyme-SRS ]   3.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
Chemical/Protein Interactions : CTD5336
Chemical/Pharm GKB GenePA33393
Clinical trialPLCG2
Cancer Resource (Charite)ENSG00000197943
Ontology : AmiGOfollicular B cell differentiation  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  protein binding  phospholipid binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol biosynthetic process  blood coagulation  phospholipid catabolic process  regulation of gene expression  Wnt receptor signaling pathway  calcium-mediated signaling  platelet activation  B cell differentiation  response to magnesium ion  activation of store-operated calcium channel activity  response to lipopolysaccharide  inositol trisphosphate biosynthetic process  response to ATP  negative regulation of programmed cell death  T cell receptor signaling pathway  B cell receptor signaling pathway  release of sequestered calcium ion into cytosol  
Ontology : EGO-EBIfollicular B cell differentiation  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  protein binding  phospholipid binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol biosynthetic process  blood coagulation  phospholipid catabolic process  regulation of gene expression  Wnt receptor signaling pathway  calcium-mediated signaling  platelet activation  B cell differentiation  response to magnesium ion  activation of store-operated calcium channel activity  response to lipopolysaccharide  inositol trisphosphate biosynthetic process  response to ATP  negative regulation of programmed cell death  T cell receptor signaling pathway  B cell receptor signaling pathway  release of sequestered calcium ion into cytosol  
Pathways : KEGGVEGF signaling pathwayInositol phosphate metabolismNatural killer cell mediated cytotoxicityEpithelial cell signaling in Helicobacter pylori infectionPhosphatidylinositol signaling systemCalcium signaling pathwayLeukocyte transendothelial migrationB cell receptor signaling pathwayFc epsilon RI signaling pathway
Other databases
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
PubGenePLCG2
iHOPPLCG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:25:47 CEST 2013
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