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PLCG2 (phospholipase C, gamma 2 (phosphatidylinositol-specific))

Identity

Other namesAPLAID
FCAS3
HGNC (Hugo) PLCG2
LocusID (NCBI) 5336
Location 16q23.3
Location_base_pair Starts at 81812899 and ends at 81991899 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLCG2   9066
Cards
Entrez_Gene (NCBI)PLCG2  5336  phospholipase C, gamma 2 (phosphatidylinositol-specific)
GeneCards (Weizmann)PLCG2
Ensembl (Hinxton)ENSG00000197943 [Gene_View]  chr16:81812899-81991899 [Contig_View]  PLCG2 [Vega]
AceView (NCBI)PLCG2
Genatlas (Paris)PLCG2
WikiGenes5336
SOURCE (Princeton)NM_002661
Genomic and cartography
GoldenPath (UCSC)PLCG2  -  16q23.3   chr16:81812899-81991899 +  16q23.3   [Description]    (hg19-Feb_2009)
EnsemblPLCG2 - 16q23.3 [CytoView]
Mapping of homologs : NCBIPLCG2 [Mapview]
OMIM600220   614468   614878   
Gene and transcription
Genbank (Entrez)AB208914 AK304722 AK310042 AW504432 AY364256
RefSeq transcript (Entrez)NM_002661
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_032019 NT_010498 NW_001838328 NW_004929402
Consensus coding sequences : CCDS (NCBI)PLCG2
Cluster EST : UnigeneHs.413111 [ NCBI ]
CGAP (NCI)Hs.413111
Alternative Splicing : Fast-db (Paris)GSHG0011394
Alternative Splicing GalleryENSG00000197943
Gene ExpressionPLCG2 [ NCBI-GEO ]     PLCG2 [ SEEK ]   PLCG2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16885 (Uniprot)
NextProtP16885  [Medical]
With graphics : InterProP16885
Splice isoforms : SwissVarP16885 (Swissvar)
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)C2_dom    PH_like_dom    Pinositol_PLipase_C    PLC-gamma    PLC-like_Pdiesterase_TIM-brl    Pleckstrin_homology    PLipase_C_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y    SH2    SH3_domain   
Related proteins : CluSTrP16885
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam00388    pfam00387    pfam00017    pfam00018   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  SH2 (SM00252)  SH3 (SM00326)  
DMDM Disease mutations5336
Blocks (Seattle)P16885
PDB (SRS)2K2J    2W2W    2W2X   
PDB (PDBSum)2K2J    2W2W    2W2X   
PDB (IMB)2K2J    2W2W    2W2X   
PDB (RSDB)2K2J    2W2W    2W2X   
Human Protein AtlasENSG00000197943
Peptide AtlasP16885
HPRD02570
IPIIPI00329185   
Protein Interaction databases
DIP (DOE-UCLA)P16885
IntAct (EBI)P16885
FunCoupENSG00000197943
BioGRIDPLCG2
InParanoidP16885
Interologous Interaction database P16885
IntegromeDBPLCG2
STRING (EMBL)PLCG2
Ontologies - Pathways
Ontology : AmiGOfollicular B cell differentiation  phosphatidylinositol phospholipase C activity  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  protein binding  phospholipid binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol biosynthetic process  blood coagulation  phospholipid catabolic process  regulation of gene expression  Wnt receptor signaling pathway  calcium-mediated signaling  platelet activation  B cell differentiation  activation of store-operated calcium channel activity  response to lipopolysaccharide  inositol trisphosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  negative regulation of programmed cell death  inositol phosphate metabolic process  small molecule metabolic process  innate immune response  T cell receptor signaling pathway  B cell receptor signaling pathway  release of sequestered calcium ion into cytosol  
Ontology : EGO-EBIfollicular B cell differentiation  phosphatidylinositol phospholipase C activity  phosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  protein binding  phospholipid binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol biosynthetic process  blood coagulation  phospholipid catabolic process  regulation of gene expression  Wnt receptor signaling pathway  calcium-mediated signaling  platelet activation  B cell differentiation  activation of store-operated calcium channel activity  response to lipopolysaccharide  inositol trisphosphate biosynthetic process  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  negative regulation of programmed cell death  inositol phosphate metabolic process  small molecule metabolic process  innate immune response  T cell receptor signaling pathway  B cell receptor signaling pathway  release of sequestered calcium ion into cytosol  
Pathways : KEGGInositol phosphate metabolism    ErbB signaling pathway    Ras signaling pathway    Calcium signaling pathway    NF-kappa B signaling pathway    HIF-1 signaling pathway    Phosphatidylinositol signaling system    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Neurotrophin signaling pathway    Thyroid hormone signaling pathway    Vibrio cholerae infection    Epithelial cell signaling in Helicobacter pylori infection    Epstein-Barr virus infection    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Glioma    Non-small cell lung cancer   
REACTOMEPLCG2
Protein Interaction DatabasePLCG2
Wikipedia pathwaysPLCG2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PLCG2
SNP (GeneSNP Utah)PLCG2
SNP : HGBasePLCG2
Genetic variants : HAPMAPPLCG2
1000_GenomesPLCG2 
ICGC programENSG00000197943 
Somatic Mutations in Cancer : COSMICPLCG2 
CONAN: Copy Number AnalysisPLCG2 
Mutations and Diseases : HGMDPLCG2
OMIM600220    614468    614878   
GENETestsPLCG2
Disease Genetic AssociationPLCG2
Huge Navigator PLCG2 [HugePedia]  PLCG2 [HugeCancerGEM]
Genomic VariantsPLCG2  PLCG2 [DGVbeta]
Exome VariantPLCG2
dbVarPLCG2
ClinVarPLCG2
snp3D : Map Gene to Disease5336
General knowledge
Homologs : HomoloGenePLCG2
Homology/Alignments : Family Browser (UCSC)PLCG2
Phylogenetic Trees/Animal Genes : TreeFamPLCG2
Chemical/Protein Interactions : CTD5336
Chemical/Pharm GKB GenePA33393
Clinical trialPLCG2
Cancer Resource (Charite)ENSG00000197943
Other databases
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
CoreMinePLCG2
iHOPPLCG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:50:11 CEST 2014

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