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PLCL1 (phospholipase C like 1)

Identity

Alias_namesPLCE
phospholipase C, epsilon
phospholipase C-like 1
Alias_symbol (synonym)PLC-L
PLCL
PRIP
PPP1R127
Other aliasPLDL1
HGNC (Hugo) PLCL1
LocusID (NCBI) 5334
Atlas_Id 46709
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 198669426 and ends at 199014608 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHID1 (11p15.5) / PLCL1 (2q33.1)KCNJ6 (21q22.13) / PLCL1 (2q33.1)MALAT1 (11q13.1) / PLCL1 (2q33.1)
PLCL1 (2q33.1) / RNF216 (7p22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCL1   9063
Cards
Entrez_Gene (NCBI)PLCL1  5334  phospholipase C like 1
AliasesPLCE; PLCL; PLDL1; PPP1R127; 
PRIP
GeneCards (Weizmann)PLCL1
Ensembl hg19 (Hinxton)ENSG00000115896 [Gene_View]  chr2:198669426-199014608 [Contig_View]  PLCL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115896 [Gene_View]  chr2:198669426-199014608 [Contig_View]  PLCL1 [Vega]
ICGC DataPortalENSG00000115896
TCGA cBioPortalPLCL1
AceView (NCBI)PLCL1
Genatlas (Paris)PLCL1
WikiGenes5334
SOURCE (Princeton)PLCL1
Genetics Home Reference (NIH)PLCL1
Genomic and cartography
GoldenPath hg19 (UCSC)PLCL1  -     chr2:198669426-199014608 +  2q33.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLCL1  -     2q33.1   [Description]    (hg38-Dec_2013)
EnsemblPLCL1 - 2q33.1 [CytoView hg19]  PLCL1 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBIPLCL1 [Mapview hg19]  PLCL1 [Mapview hg38]
OMIM600597   
Gene and transcription
Genbank (Entrez)AK127514 AK302673 BC101531 BC111985 BP340710
RefSeq transcript (Entrez)NM_006226
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)PLCL1
Cluster EST : UnigeneHs.153322 [ NCBI ]
CGAP (NCI)Hs.153322
Alternative Splicing GalleryENSG00000115896
Gene ExpressionPLCL1 [ NCBI-GEO ]   PLCL1 [ EBI - ARRAY_EXPRESS ]   PLCL1 [ SEEK ]   PLCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5334
GTEX Portal (Tissue expression)PLCL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15111   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15111  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15111
Splice isoforms : SwissVarQ15111
PhosPhoSitePlusQ15111
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    PH_dom-like    PH_domain    PI-PLC_fam    PLC-like_Pdiesterase_TIM-brl    PLC_EF-hand-like    PLCL1    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_like (PF09279)    PH_12 (PF16457)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam16457    pfam00388    pfam00387   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  
Conserved Domain (NCBI)PLCL1
DMDM Disease mutations5334
Blocks (Seattle)PLCL1
SuperfamilyQ15111
Human Protein AtlasENSG00000115896
Peptide AtlasQ15111
HPRD07041
IPIIPI00789181   IPI00006660   IPI00925846   
Protein Interaction databases
DIP (DOE-UCLA)Q15111
IntAct (EBI)Q15111
FunCoupENSG00000115896
BioGRIDPLCL1
STRING (EMBL)PLCL1
ZODIACPLCL1
Ontologies - Pathways
QuickGOQ15111
Ontology : AmiGOphosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  cytoplasm  plasma membrane  lipid metabolic process  gamma-aminobutyric acid signaling pathway  regulation of synaptic transmission, GABAergic  regulation of peptidyl-serine phosphorylation  intracellular signal transduction  GABA receptor binding  inositol 1,4,5 trisphosphate binding  positive regulation of receptor binding  
Ontology : EGO-EBIphosphatidylinositol phospholipase C activity  phospholipase C activity  signal transducer activity  cytoplasm  plasma membrane  lipid metabolic process  gamma-aminobutyric acid signaling pathway  regulation of synaptic transmission, GABAergic  regulation of peptidyl-serine phosphorylation  intracellular signal transduction  GABA receptor binding  inositol 1,4,5 trisphosphate binding  positive regulation of receptor binding  
Pathways : KEGGGABAergic synapse   
NDEx NetworkPLCL1
Atlas of Cancer Signalling NetworkPLCL1
Wikipedia pathwaysPLCL1
Orthology - Evolution
OrthoDB5334
GeneTree (enSembl)ENSG00000115896
Phylogenetic Trees/Animal Genes : TreeFamPLCL1
HOVERGENQ15111
HOGENOMQ15111
Homologs : HomoloGenePLCL1
Homology/Alignments : Family Browser (UCSC)PLCL1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLCL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCL1
dbVarPLCL1
ClinVarPLCL1
1000_GenomesPLCL1 
Exome Variant ServerPLCL1
ExAC (Exome Aggregation Consortium)PLCL1 (select the gene name)
Genetic variants : HAPMAP5334
Genomic Variants (DGV)PLCL1 [DGVbeta]
DECIPHER (Syndromes)2:198669426-199014608  ENSG00000115896
CONAN: Copy Number AnalysisPLCL1 
Mutations
ICGC Data PortalPLCL1 
TCGA Data PortalPLCL1 
Broad Tumor PortalPLCL1
OASIS PortalPLCL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLCL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLCL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLCL1
DgiDB (Drug Gene Interaction Database)PLCL1
DoCM (Curated mutations)PLCL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCL1 (select a term)
intoGenPLCL1
Cancer3DPLCL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600597   
Orphanet
MedgenPLCL1
Genetic Testing Registry PLCL1
NextProtQ15111 [Medical]
TSGene5334
GENETestsPLCL1
Huge Navigator PLCL1 [HugePedia]
snp3D : Map Gene to Disease5334
BioCentury BCIQPLCL1
ClinGenPLCL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5334
Chemical/Pharm GKB GenePA33394
Clinical trialPLCL1
Miscellaneous
canSAR (ICR)PLCL1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCL1
EVEXPLCL1
GoPubMedPLCL1
iHOPPLCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:14:37 CEST 2017

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