Identity
HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
PLCE,PLCL,PLDL1,PPP1R127,PRIP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5334
MIM: 600597
HGNC: 9063
Ensembl: ENSG00000115896
Variants:
dbSNP: 5334
ClinVar: 5334
TCGA: ENSG00000115896
COSMIC: PLCL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115896 | ENST00000428675 | Q15111 |
| ENSG00000115896 | ENST00000435320 | F8WAR2 |
| ENSG00000115896 | ENST00000437704 | A0A0A0MT40 |
| ENSG00000115896 | ENST00000487695 | H3BUD4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| GABAergic synapse | KEGG | ko04727 |
| GABAergic synapse | KEGG | hsa04727 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA26097 | CASR | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA33767 | PRKCH | Gene | Pathway | associated | |||
| PA33768 | PRKCI | Gene | Pathway | associated | |||
| PA33771 | PRKD1 | Gene | Pathway | associated | |||
| PA33775 | PRKCZ | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37801481 | 2023 | PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma. | 1 |
| 37801481 | 2023 | PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma. | 1 |
| 35820936 | 2022 | PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis. | 2 |
| 35820936 | 2022 | PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis. | 2 |
| 34115876 | 2021 | Identification of novel pleiotropic gene for bone mineral density and lean mass using the cFDR method. | 1 |
| 34115876 | 2021 | Identification of novel pleiotropic gene for bone mineral density and lean mass using the cFDR method. | 1 |
| 26603167 | 2016 | Positive association of genetic variations in the phospholipase C-like 1 gene with dermatomyositis in Chinese Han. | 10 |
| 26603167 | 2016 | Positive association of genetic variations in the phospholipase C-like 1 gene with dermatomyositis in Chinese Han. | 10 |
| 23911386 | 2013 | Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation. | 7 |
| 23911386 | 2013 | Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation. | 7 |
| 22128345 | 2012 | Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype. | 8 |
| 22128345 | 2012 | Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype. | 8 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
Citation
Dessen P
PLCL1 (phospholipase C like 1 (inactive))
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46709/plcl1
