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PLCL2 (phospholipase C like 2)

Identity

Alias_namesPLCE2
phospholipase C, epsilon 2
phospholipase C-like 2
Alias_symbol (synonym)KIAA1092
Other alias
HGNC (Hugo) PLCL2
LocusID (NCBI) 23228
Atlas_Id 46958
Location 3p24.3  [Link to chromosome band 3p24]
Location_base_pair Starts at 16926452 and ends at 17132098 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EFHB (3p24.3) / PLCL2 (3p24.3)PLCL2 (3p24.3) / SH3BGR (21q22.2)EFHB 3p24.3 / PLCL2 3p24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCL2   9064
Cards
Entrez_Gene (NCBI)PLCL2  23228  phospholipase C like 2
AliasesPLCE2
GeneCards (Weizmann)PLCL2
Ensembl hg19 (Hinxton)ENSG00000154822 [Gene_View]  chr3:16926452-17132098 [Contig_View]  PLCL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154822 [Gene_View]  chr3:16926452-17132098 [Contig_View]  PLCL2 [Vega]
ICGC DataPortalENSG00000154822
TCGA cBioPortalPLCL2
AceView (NCBI)PLCL2
Genatlas (Paris)PLCL2
WikiGenes23228
SOURCE (Princeton)PLCL2
Genetics Home Reference (NIH)PLCL2
Genomic and cartography
GoldenPath hg19 (UCSC)PLCL2  -     chr3:16926452-17132098 +  3p24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLCL2  -     3p24.3   [Description]    (hg38-Dec_2013)
EnsemblPLCL2 - 3p24.3 [CytoView hg19]  PLCL2 - 3p24.3 [CytoView hg38]
Mapping of homologs : NCBIPLCL2 [Mapview hg19]  PLCL2 [Mapview hg38]
OMIM614276   
Gene and transcription
Genbank (Entrez)AB029015 AK023546 AK291419 AK309946 AL117515
RefSeq transcript (Entrez)NM_001144382 NM_015184
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)PLCL2
Cluster EST : UnigeneHs.741267 [ NCBI ]
CGAP (NCI)Hs.741267
Alternative Splicing GalleryENSG00000154822
Gene ExpressionPLCL2 [ NCBI-GEO ]   PLCL2 [ EBI - ARRAY_EXPRESS ]   PLCL2 [ SEEK ]   PLCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23228
GTEX Portal (Tissue expression)PLCL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPR0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPR0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPR0
Splice isoforms : SwissVarQ9UPR0
PhosPhoSitePlusQ9UPR0
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    PH_DOMAIN (PS50003)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    PH_dom-like    PH_domain    PI-PLC_fam    PLC-like_Pdiesterase_TIM-brl    PLC_EF-hand-like    PLCL2    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_like (PF09279)    PH_12 (PF16457)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam16457    pfam00388    pfam00387   
Domain families : Smart (EMBL)C2 (SM00239)  PH (SM00233)  PLCXc (SM00148)  PLCYc (SM00149)  
Conserved Domain (NCBI)PLCL2
DMDM Disease mutations23228
Blocks (Seattle)PLCL2
SuperfamilyQ9UPR0
Human Protein AtlasENSG00000154822
Peptide AtlasQ9UPR0
HPRD07147
IPIIPI00789859   IPI00010334   IPI00847504   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPR0
IntAct (EBI)Q9UPR0
FunCoupENSG00000154822
BioGRIDPLCL2
STRING (EMBL)PLCL2
ZODIACPLCL2
Ontologies - Pathways
QuickGOQ9UPR0
Ontology : AmiGOB cell proliferation involved in immune response  B-1a B cell differentiation  phosphatidylinositol phospholipase C activity  signal transducer activity  cytoplasm  lipid metabolic process  gamma-aminobutyric acid signaling pathway  regulation of synaptic transmission, GABAergic  regulation of peptidyl-serine phosphorylation  intracellular signal transduction  GABA receptor binding  negative regulation of B cell receptor signaling pathway  positive regulation of receptor binding  
Ontology : EGO-EBIB cell proliferation involved in immune response  B-1a B cell differentiation  phosphatidylinositol phospholipase C activity  signal transducer activity  cytoplasm  lipid metabolic process  gamma-aminobutyric acid signaling pathway  regulation of synaptic transmission, GABAergic  regulation of peptidyl-serine phosphorylation  intracellular signal transduction  GABA receptor binding  negative regulation of B cell receptor signaling pathway  positive regulation of receptor binding  
NDEx NetworkPLCL2
Atlas of Cancer Signalling NetworkPLCL2
Wikipedia pathwaysPLCL2
Orthology - Evolution
OrthoDB23228
GeneTree (enSembl)ENSG00000154822
Phylogenetic Trees/Animal Genes : TreeFamPLCL2
HOVERGENQ9UPR0
HOGENOMQ9UPR0
Homologs : HomoloGenePLCL2
Homology/Alignments : Family Browser (UCSC)PLCL2
Gene fusions - Rearrangements
Fusion : MitelmanEFHB/PLCL2 [3p24.3/3p24.3]  [t(3;3)(p24;p24)]  
Fusion: TCGAEFHB 3p24.3 PLCL2 3p24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCL2
dbVarPLCL2
ClinVarPLCL2
1000_GenomesPLCL2 
Exome Variant ServerPLCL2
ExAC (Exome Aggregation Consortium)PLCL2 (select the gene name)
Genetic variants : HAPMAP23228
Genomic Variants (DGV)PLCL2 [DGVbeta]
DECIPHER (Syndromes)3:16926452-17132098  ENSG00000154822
CONAN: Copy Number AnalysisPLCL2 
Mutations
ICGC Data PortalPLCL2 
TCGA Data PortalPLCL2 
Broad Tumor PortalPLCL2
OASIS PortalPLCL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLCL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLCL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLCL2
DgiDB (Drug Gene Interaction Database)PLCL2
DoCM (Curated mutations)PLCL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCL2 (select a term)
intoGenPLCL2
Cancer3DPLCL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614276   
Orphanet
MedgenPLCL2
Genetic Testing Registry PLCL2
NextProtQ9UPR0 [Medical]
TSGene23228
GENETestsPLCL2
Huge Navigator PLCL2 [HugePedia]
snp3D : Map Gene to Disease23228
BioCentury BCIQPLCL2
ClinGenPLCL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23228
Chemical/Pharm GKB GenePA33395
Clinical trialPLCL2
Miscellaneous
canSAR (ICR)PLCL2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCL2
EVEXPLCL2
GoPubMedPLCL2
iHOPPLCL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:21:43 CET 2017

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