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PLCZ1 (phospholipase C zeta 1)

Identity

Alias_namesphospholipase C
Alias_symbol (synonym)NYD-SP27
PLCzeta
Other aliasPLC-zeta-1
SPGF17
HGNC (Hugo) PLCZ1
LocusID (NCBI) 89869
Atlas_Id 47130
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 18683180 and ends at 18737509 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C2CD5 (12p12.1) / PLCZ1 (12p12.3)CLSTN3 (12p13.31) / PLCZ1 (12p12.3)DENND5B (12p11.21) / PLCZ1 (12p12.3)
PLCZ1 (12p12.3) / GNPTG (16p13.3)CLSTN3 12p13.31 / PLCZ1 12p12.3DENND5B 12p11.21 / PLCZ1 12p12.3
KIAA0528 PLCZ1 12p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLCZ1   19218
Cards
Entrez_Gene (NCBI)PLCZ1  89869  phospholipase C zeta 1
AliasesNYD-SP27; PLC-zeta-1; PLCzeta; SPGF17
GeneCards (Weizmann)PLCZ1
Ensembl hg19 (Hinxton)ENSG00000139151 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139151 [Gene_View]  chr12:18683180-18737509 [Contig_View]  PLCZ1 [Vega]
ICGC DataPortalENSG00000139151
TCGA cBioPortalPLCZ1
AceView (NCBI)PLCZ1
Genatlas (Paris)PLCZ1
WikiGenes89869
SOURCE (Princeton)PLCZ1
Genetics Home Reference (NIH)PLCZ1
Genomic and cartography
GoldenPath hg38 (UCSC)PLCZ1  -     chr12:18683180-18737509 -  12p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLCZ1  -     12p12.3   [Description]    (hg19-Feb_2009)
EnsemblPLCZ1 - 12p12.3 [CytoView hg19]  PLCZ1 - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBIPLCZ1 [Mapview hg19]  PLCZ1 [Mapview hg38]
OMIM608075   617214   
Gene and transcription
Genbank (Entrez)AA812556 AF532185 AK097555 AK097725 AK292279
RefSeq transcript (Entrez)NM_001330769 NM_001330774 NM_033123
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLCZ1
Cluster EST : UnigeneHs.743832 [ NCBI ]
CGAP (NCI)Hs.743832
Alternative Splicing GalleryENSG00000139151
Gene ExpressionPLCZ1 [ NCBI-GEO ]   PLCZ1 [ EBI - ARRAY_EXPRESS ]   PLCZ1 [ SEEK ]   PLCZ1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLCZ1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89869
GTEX Portal (Tissue expression)PLCZ1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YW0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YW0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YW0
Splice isoforms : SwissVarQ86YW0
Catalytic activity : Enzyme3.1.4.11 [ Enzyme-Expasy ]   3.1.4.113.1.4.11 [ IntEnz-EBI ]   3.1.4.11 [ BRENDA ]   3.1.4.11 [ KEGG ]   
PhosPhoSitePlusQ86YW0
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    EF_HAND_2 (PS50222)    PIPLC_X_DOMAIN (PS50007)    PIPLC_Y_DOMAIN (PS50008)   
Domains : Interpro (EBI)C2_dom    EF-hand-dom_pair    EF_hand_dom    PI-PLC_fam    PLC-like_Pdiesterase_TIM-brl    PLC-zeta1    PLC_EF-hand-like    PLipase_C_PInositol-sp_X_dom    PLipase_C_Pinositol-sp_Y   
Domain families : Pfam (Sanger)C2 (PF00168)    EF-hand_like (PF09279)    PI-PLC-X (PF00388)    PI-PLC-Y (PF00387)   
Domain families : Pfam (NCBI)pfam00168    pfam09279    pfam00388    pfam00387   
Domain families : Smart (EMBL)C2 (SM00239)  PLCXc (SM00148)  PLCYc (SM00149)  
Conserved Domain (NCBI)PLCZ1
DMDM Disease mutations89869
Blocks (Seattle)PLCZ1
SuperfamilyQ86YW0
Human Protein AtlasENSG00000139151
Peptide AtlasQ86YW0
HPRD06996
IPIIPI00172666   IPI00792324   IPI00384651   IPI00182449   IPI01014467   IPI01014311   IPI01012750   IPI00791906   IPI01012208   IPI01013467   IPI01011299   IPI01012675   IPI01010242   
Protein Interaction databases
DIP (DOE-UCLA)Q86YW0
IntAct (EBI)Q86YW0
FunCoupENSG00000139151
BioGRIDPLCZ1
STRING (EMBL)PLCZ1
ZODIACPLCZ1
Ontologies - Pathways
QuickGOQ86YW0
Ontology : AmiGOphosphatidylinositol phospholipase C activity  signal transducer activity  calcium ion binding  nucleus  cytosol  calcium ion transport  multicellular organism development  egg activation  lipid catabolic process  intracellular signal transduction  inositol phosphate metabolic process  perinuclear region of cytoplasm  
Ontology : EGO-EBIphosphatidylinositol phospholipase C activity  signal transducer activity  calcium ion binding  nucleus  cytosol  calcium ion transport  multicellular organism development  egg activation  lipid catabolic process  intracellular signal transduction  inositol phosphate metabolic process  perinuclear region of cytoplasm  
Pathways : KEGGInositol phosphate metabolism    Calcium signaling pathway    Phosphatidylinositol signaling system    Oocyte meiosis    Thyroid hormone signaling pathway   
NDEx NetworkPLCZ1
Atlas of Cancer Signalling NetworkPLCZ1
Wikipedia pathwaysPLCZ1
Orthology - Evolution
OrthoDB89869
GeneTree (enSembl)ENSG00000139151
Phylogenetic Trees/Animal Genes : TreeFamPLCZ1
HOVERGENQ86YW0
HOGENOMQ86YW0
Homologs : HomoloGenePLCZ1
Homology/Alignments : Family Browser (UCSC)PLCZ1
Gene fusions - Rearrangements
Fusion : MitelmanC2CD5/PLCZ1 [12p12.1/12p12.3]  [t(12;12)(p12;p12)]  
Fusion : MitelmanCLSTN3/PLCZ1 [12p13.31/12p12.3]  [t(12;12)(p12;p13)]  
Fusion : MitelmanDENND5B/PLCZ1 [12p11.21/12p12.3]  [t(12;12)(p11;p12)]  
Fusion: TCGACLSTN3 12p13.31 PLCZ1 12p12.3 BRCA
Fusion: TCGADENND5B 12p11.21 PLCZ1 12p12.3 LGG
Fusion: TCGAKIAA0528 PLCZ1 12p12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLCZ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLCZ1
dbVarPLCZ1
ClinVarPLCZ1
1000_GenomesPLCZ1 
Exome Variant ServerPLCZ1
ExAC (Exome Aggregation Consortium)PLCZ1 (select the gene name)
Genetic variants : HAPMAP89869
Genomic Variants (DGV)PLCZ1 [DGVbeta]
DECIPHERPLCZ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLCZ1 
Mutations
ICGC Data PortalPLCZ1 
TCGA Data PortalPLCZ1 
Broad Tumor PortalPLCZ1
OASIS PortalPLCZ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLCZ1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLCZ1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLCZ1
DgiDB (Drug Gene Interaction Database)PLCZ1
DoCM (Curated mutations)PLCZ1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLCZ1 (select a term)
intoGenPLCZ1
Cancer3DPLCZ1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608075    617214   
Orphanet
MedgenPLCZ1
Genetic Testing Registry PLCZ1
NextProtQ86YW0 [Medical]
TSGene89869
GENETestsPLCZ1
Huge Navigator PLCZ1 [HugePedia]
snp3D : Map Gene to Disease89869
BioCentury BCIQPLCZ1
ClinGenPLCZ1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89869
Chemical/Pharm GKB GenePA134875646
Clinical trialPLCZ1
Miscellaneous
canSAR (ICR)PLCZ1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLCZ1
EVEXPLCZ1
GoPubMedPLCZ1
iHOPPLCZ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:31:33 CEST 2017

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