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PLD3 (phospholipase D family member 3)

Identity

Alias_namesphospholipase D3
phospholipase D family, member 3
Alias_symbol (synonym)HU-K4
Other aliasAD19
HUK4
HGNC (Hugo) PLD3
LocusID (NCBI) 23646
Atlas_Id 71971
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 40348425 and ends at 40378490 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EGLN2 (19q13.2) / PLD3 (19q13.2)GREB1L (18q11.1) / PLD3 (19q13.2)PLD3 (19q13.2) / CAPZA1 (1p13.2)
PLD3 (19q13.2) / CPNE5 (6p21.2)PLD3 (19q13.2) / LOC100507412 (-)PLD3 (19q13.2) / NCALD (8q22.3)
PLD3 (19q13.2) / PLD3 (19q13.2)PLD3 (19q13.2) / SIRT2 (19q13.2)PLD3 SIRT2
PLD3 NCALD

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLD3   17158
Cards
Entrez_Gene (NCBI)PLD3  23646  phospholipase D family member 3
AliasesAD19; HU-K4; HUK4
GeneCards (Weizmann)PLD3
Ensembl hg19 (Hinxton)ENSG00000105223 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105223 [Gene_View]  chr19:40348425-40378490 [Contig_View]  PLD3 [Vega]
ICGC DataPortalENSG00000105223
TCGA cBioPortalPLD3
AceView (NCBI)PLD3
Genatlas (Paris)PLD3
WikiGenes23646
SOURCE (Princeton)PLD3
Genetics Home Reference (NIH)PLD3
Genomic and cartography
GoldenPath hg38 (UCSC)PLD3  -     chr19:40348425-40378490 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLD3  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblPLD3 - 19q13.2 [CytoView hg19]  PLD3 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIPLD3 [Mapview hg19]  PLD3 [Mapview hg38]
OMIM615698   615711   
Gene and transcription
Genbank (Entrez)AK293690 AY927565 BC000553 BC036327 BC096820
RefSeq transcript (Entrez)NM_001031696 NM_001291311 NM_012268
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLD3
Cluster EST : UnigeneHs.257008 [ NCBI ]
CGAP (NCI)Hs.257008
Alternative Splicing GalleryENSG00000105223
Gene ExpressionPLD3 [ NCBI-GEO ]   PLD3 [ EBI - ARRAY_EXPRESS ]   PLD3 [ SEEK ]   PLD3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23646
GTEX Portal (Tissue expression)PLD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IV08   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IV08  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IV08
Splice isoforms : SwissVarQ8IV08
Catalytic activity : Enzyme3.1.4.4 [ Enzyme-Expasy ]   3.1.4.43.1.4.4 [ IntEnz-EBI ]   3.1.4.4 [ BRENDA ]   3.1.4.4 [ KEGG ]   
PhosPhoSitePlusQ8IV08
Domaine pattern : Prosite (Expaxy)PLD (PS50035)   
Domains : Interpro (EBI)PLDc_3    PLipase_D/transphosphatidylase   
Domain families : Pfam (Sanger)PLDc (PF00614)    PLDc_3 (PF13918)   
Domain families : Pfam (NCBI)pfam00614    pfam13918   
Domain families : Smart (EMBL)PLDc (SM00155)  
Conserved Domain (NCBI)PLD3
DMDM Disease mutations23646
Blocks (Seattle)PLD3
SuperfamilyQ8IV08
Human Protein AtlasENSG00000105223
Peptide AtlasQ8IV08
HPRD07148
IPIIPI00328243   IPI01014901   IPI00916909   IPI00917074   
Protein Interaction databases
DIP (DOE-UCLA)Q8IV08
IntAct (EBI)Q8IV08
FunCoupENSG00000105223
BioGRIDPLD3
STRING (EMBL)PLD3
ZODIACPLD3
Ontologies - Pathways
QuickGOQ8IV08
Ontology : AmiGOphospholipase D activity  protein binding  endoplasmic reticulum membrane  integral component of membrane  lipid catabolic process  extracellular exosome  N-acylphosphatidylethanolamine-specific phospholipase D activity  
Ontology : EGO-EBIphospholipase D activity  protein binding  endoplasmic reticulum membrane  integral component of membrane  lipid catabolic process  extracellular exosome  N-acylphosphatidylethanolamine-specific phospholipase D activity  
Pathways : BIOCARTAMetabolism of Anandamide, an Endogenous Cannabinoid [Genes]   
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism   
NDEx NetworkPLD3
Atlas of Cancer Signalling NetworkPLD3
Wikipedia pathwaysPLD3
Orthology - Evolution
OrthoDB23646
GeneTree (enSembl)ENSG00000105223
Phylogenetic Trees/Animal Genes : TreeFamPLD3
HOVERGENQ8IV08
HOGENOMQ8IV08
Homologs : HomoloGenePLD3
Homology/Alignments : Family Browser (UCSC)PLD3
Gene fusions - Rearrangements
Fusion: TCGAPLD3 SIRT2
Fusion: TCGAPLD3 NCALD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLD3
dbVarPLD3
ClinVarPLD3
1000_GenomesPLD3 
Exome Variant ServerPLD3
ExAC (Exome Aggregation Consortium)PLD3 (select the gene name)
Genetic variants : HAPMAP23646
Genomic Variants (DGV)PLD3 [DGVbeta]
DECIPHERPLD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLD3 
Mutations
ICGC Data PortalPLD3 
TCGA Data PortalPLD3 
Broad Tumor PortalPLD3
OASIS PortalPLD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLD3
DgiDB (Drug Gene Interaction Database)PLD3
DoCM (Curated mutations)PLD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLD3 (select a term)
intoGenPLD3
Cancer3DPLD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615698    615711   
Orphanet
MedgenPLD3
Genetic Testing Registry PLD3
NextProtQ8IV08 [Medical]
TSGene23646
GENETestsPLD3
Target ValidationPLD3
Huge Navigator PLD3 [HugePedia]
snp3D : Map Gene to Disease23646
BioCentury BCIQPLD3
ClinGenPLD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23646
Chemical/Pharm GKB GenePA134887482
Clinical trialPLD3
Miscellaneous
canSAR (ICR)PLD3 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLD3
EVEXPLD3
GoPubMedPLD3
iHOPPLD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:34:43 CEST 2017

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