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PLD4 (phospholipase D family member 4)

Identity

Alias_namesC14orf175
chromosome 14 open reading frame 175
phospholipase D family, member 4
Other alias
HGNC (Hugo) PLD4
LocusID (NCBI) 122618
Atlas_Id 54541
Location 14q32.33  [Link to chromosome band 14q32]
Location_base_pair Starts at 104924816 and ends at 104933236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLD4 (14q32.33) / AHNAK2 (14q32.33)UBXN7 (3q29) / PLD4 (14q32.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLD4   23792
Cards
Entrez_Gene (NCBI)PLD4  122618  phospholipase D family member 4
AliasesC14orf175
GeneCards (Weizmann)PLD4
Ensembl hg19 (Hinxton)ENSG00000166428 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166428 [Gene_View]  chr14:104924816-104933236 [Contig_View]  PLD4 [Vega]
ICGC DataPortalENSG00000166428
TCGA cBioPortalPLD4
AceView (NCBI)PLD4
Genatlas (Paris)PLD4
WikiGenes122618
SOURCE (Princeton)PLD4
Genetics Home Reference (NIH)PLD4
Genomic and cartography
GoldenPath hg38 (UCSC)PLD4  -     chr14:104924816-104933236 +  14q32.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLD4  -     14q32.33   [Description]    (hg19-Feb_2009)
EnsemblPLD4 - 14q32.33 [CytoView hg19]  PLD4 - 14q32.33 [CytoView hg38]
Mapping of homologs : NCBIPLD4 [Mapview hg19]  PLD4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK295352 AK296188 AW104909 AY358843 BC015003
RefSeq transcript (Entrez)NM_001308174 NM_138790
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLD4
Cluster EST : UnigeneHs.407101 [ NCBI ]
CGAP (NCI)Hs.407101
Alternative Splicing GalleryENSG00000166428
Gene ExpressionPLD4 [ NCBI-GEO ]   PLD4 [ EBI - ARRAY_EXPRESS ]   PLD4 [ SEEK ]   PLD4 [ MEM ]
Gene Expression Viewer (FireBrowse)PLD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)122618
GTEX Portal (Tissue expression)PLD4
Human Protein AtlasENSG00000166428-PLD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BZ4
Splice isoforms : SwissVarQ96BZ4
Catalytic activity : Enzyme3.1.4.4 [ Enzyme-Expasy ]   3.1.4.43.1.4.4 [ IntEnz-EBI ]   3.1.4.4 [ BRENDA ]   3.1.4.4 [ KEGG ]   
PhosPhoSitePlusQ96BZ4
Domaine pattern : Prosite (Expaxy)PLD (PS50035)   
Domains : Interpro (EBI)PLDc_3    PLipase_D/transphosphatidylase   
Domain families : Pfam (Sanger)PLDc (PF00614)    PLDc_3 (PF13918)   
Domain families : Pfam (NCBI)pfam00614    pfam13918   
Domain families : Smart (EMBL)PLDc (SM00155)  
Conserved Domain (NCBI)PLD4
DMDM Disease mutations122618
Blocks (Seattle)PLD4
SuperfamilyQ96BZ4
Human Protein Atlas [tissue]ENSG00000166428-PLD4 [tissue]
Peptide AtlasQ96BZ4
HPRD11230
IPIIPI01010014   IPI00060310   IPI01025049   IPI01026531   
Protein Interaction databases
DIP (DOE-UCLA)Q96BZ4
IntAct (EBI)Q96BZ4
FunCoupENSG00000166428
BioGRIDPLD4
STRING (EMBL)PLD4
ZODIACPLD4
Ontologies - Pathways
QuickGOQ96BZ4
Ontology : AmiGOphosphatidylinositol phospholipase C activity  phospholipase D activity  endoplasmic reticulum membrane  integral component of membrane  lipid catabolic process  inositol phosphate metabolic process  N-acylphosphatidylethanolamine-specific phospholipase D activity  
Ontology : EGO-EBIphosphatidylinositol phospholipase C activity  phospholipase D activity  endoplasmic reticulum membrane  integral component of membrane  lipid catabolic process  inositol phosphate metabolic process  N-acylphosphatidylethanolamine-specific phospholipase D activity  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism   
NDEx NetworkPLD4
Atlas of Cancer Signalling NetworkPLD4
Wikipedia pathwaysPLD4
Orthology - Evolution
OrthoDB122618
GeneTree (enSembl)ENSG00000166428
Phylogenetic Trees/Animal Genes : TreeFamPLD4
HOVERGENQ96BZ4
HOGENOMQ96BZ4
Homologs : HomoloGenePLD4
Homology/Alignments : Family Browser (UCSC)PLD4
Gene fusions - Rearrangements
Fusion : MitelmanPLD4/AHNAK2 [14q32.33/14q32.33]  
Tumor Fusion PortalPLD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLD4
dbVarPLD4
ClinVarPLD4
1000_GenomesPLD4 
Exome Variant ServerPLD4
ExAC (Exome Aggregation Consortium)ENSG00000166428
GNOMAD BrowserENSG00000166428
Genetic variants : HAPMAP122618
Genomic Variants (DGV)PLD4 [DGVbeta]
DECIPHERPLD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLD4 
Mutations
ICGC Data PortalPLD4 
TCGA Data PortalPLD4 
Broad Tumor PortalPLD4
OASIS PortalPLD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLD4
DgiDB (Drug Gene Interaction Database)PLD4
DoCM (Curated mutations)PLD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLD4 (select a term)
intoGenPLD4
Cancer3DPLD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPLD4
MedgenPLD4
Genetic Testing Registry PLD4
NextProtQ96BZ4 [Medical]
TSGene122618
GENETestsPLD4
Target ValidationPLD4
Huge Navigator PLD4 [HugePedia]
snp3D : Map Gene to Disease122618
BioCentury BCIQPLD4
ClinGenPLD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD122618
Chemical/Pharm GKB GenePA134861676
Clinical trialPLD4
Miscellaneous
canSAR (ICR)PLD4 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLD4
EVEXPLD4
GoPubMedPLD4
iHOPPLD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:29:06 CET 2017

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