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PLD6 (phospholipase D family member 6)

Identity

Alias_namesphospholipase D family
Other aliasZUC
HGNC (Hugo) PLD6
LocusID (NCBI) 201164
Atlas_Id 56451
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 17200995 and ends at 17206332 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BMP7 (20q13.31) / PLD6 (17p11.2)PLD6 (17p11.2) / IFNAR1 (21q22.11)PLD6 (17p11.2) / TNS1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLD6   30447
Cards
Entrez_Gene (NCBI)PLD6  201164  phospholipase D family member 6
AliasesZUC
GeneCards (Weizmann)PLD6
Ensembl hg19 (Hinxton)ENSG00000179598 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179598 [Gene_View]  chr17:17200995-17206332 [Contig_View]  PLD6 [Vega]
ICGC DataPortalENSG00000179598
TCGA cBioPortalPLD6
AceView (NCBI)PLD6
Genatlas (Paris)PLD6
WikiGenes201164
SOURCE (Princeton)PLD6
Genetics Home Reference (NIH)PLD6
Genomic and cartography
GoldenPath hg38 (UCSC)PLD6  -     chr17:17200995-17206332 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLD6  -     17p11.2   [Description]    (hg19-Feb_2009)
EnsemblPLD6 - 17p11.2 [CytoView hg19]  PLD6 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIPLD6 [Mapview hg19]  PLD6 [Mapview hg38]
OMIM614960   
Gene and transcription
Genbank (Entrez)AK090899 AK098419 AK295282 BC031263 DC326979
RefSeq transcript (Entrez)NM_178836
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLD6
Cluster EST : UnigeneHs.729079 [ NCBI ]
CGAP (NCI)Hs.729079
Alternative Splicing GalleryENSG00000179598
Gene ExpressionPLD6 [ NCBI-GEO ]   PLD6 [ EBI - ARRAY_EXPRESS ]   PLD6 [ SEEK ]   PLD6 [ MEM ]
Gene Expression Viewer (FireBrowse)PLD6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201164
GTEX Portal (Tissue expression)PLD6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2A8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2A8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2A8
Splice isoforms : SwissVarQ8N2A8
PhosPhoSitePlusQ8N2A8
Domaine pattern : Prosite (Expaxy)PLD (PS50035)   
Domains : Interpro (EBI)PLD-like_dom    PLipase_D/transphosphatidylase   
Domain families : Pfam (Sanger)PLDc_2 (PF13091)   
Domain families : Pfam (NCBI)pfam13091   
Domain families : Smart (EMBL)PLDc (SM00155)  
Conserved Domain (NCBI)PLD6
DMDM Disease mutations201164
Blocks (Seattle)PLD6
SuperfamilyQ8N2A8
Human Protein AtlasENSG00000179598
Peptide AtlasQ8N2A8
HPRD14126
IPIIPI00251454   IPI00910078   IPI00384594   
Protein Interaction databases
DIP (DOE-UCLA)Q8N2A8
IntAct (EBI)Q8N2A8
FunCoupENSG00000179598
BioGRIDPLD6
STRING (EMBL)PLD6
ZODIACPLD6
Ontologies - Pathways
QuickGOQ8N2A8
Ontology : AmiGOendonuclease activity  protein binding  mitochondrial outer membrane  spermatid development  mitochondrial fusion  positive regulation of mitochondrial fusion  integral component of membrane  lipid catabolic process  P granule organization  piRNA metabolic process  cardiolipin hydrolase activity  protein homodimerization activity  DNA methylation involved in gamete generation  metal ion binding  meiotic cell cycle  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIendonuclease activity  protein binding  mitochondrial outer membrane  spermatid development  mitochondrial fusion  positive regulation of mitochondrial fusion  integral component of membrane  lipid catabolic process  P granule organization  piRNA metabolic process  cardiolipin hydrolase activity  protein homodimerization activity  DNA methylation involved in gamete generation  metal ion binding  meiotic cell cycle  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkPLD6
Atlas of Cancer Signalling NetworkPLD6
Wikipedia pathwaysPLD6
Orthology - Evolution
OrthoDB201164
GeneTree (enSembl)ENSG00000179598
Phylogenetic Trees/Animal Genes : TreeFamPLD6
HOVERGENQ8N2A8
HOGENOMQ8N2A8
Homologs : HomoloGenePLD6
Homology/Alignments : Family Browser (UCSC)PLD6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLD6
dbVarPLD6
ClinVarPLD6
1000_GenomesPLD6 
Exome Variant ServerPLD6
ExAC (Exome Aggregation Consortium)PLD6 (select the gene name)
Genetic variants : HAPMAP201164
Genomic Variants (DGV)PLD6 [DGVbeta]
DECIPHERPLD6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLD6 
Mutations
ICGC Data PortalPLD6 
TCGA Data PortalPLD6 
Broad Tumor PortalPLD6
OASIS PortalPLD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLD6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLD6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLD6
DgiDB (Drug Gene Interaction Database)PLD6
DoCM (Curated mutations)PLD6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLD6 (select a term)
intoGenPLD6
Cancer3DPLD6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614960   
Orphanet
MedgenPLD6
Genetic Testing Registry PLD6
NextProtQ8N2A8 [Medical]
TSGene201164
GENETestsPLD6
Huge Navigator PLD6 [HugePedia]
snp3D : Map Gene to Disease201164
BioCentury BCIQPLD6
ClinGenPLD6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD201164
Chemical/Pharm GKB GenePA164724625
Clinical trialPLD6
Miscellaneous
canSAR (ICR)PLD6 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLD6
EVEXPLD6
GoPubMedPLD6
iHOPPLD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:33 CEST 2017

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