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PLEK (pleckstrin)

Identity

Alias_symbol (synonym)P47
Other alias
HGNC (Hugo) PLEK
LocusID (NCBI) 5341
Atlas_Id 46495
Location 2p14  [Link to chromosome band 2p14]
Location_base_pair Starts at 68365190 and ends at 68397453 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLEK (2p14) / PLEK (2p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEK   9070
Cards
Entrez_Gene (NCBI)PLEK  5341  pleckstrin
AliasesP47
GeneCards (Weizmann)PLEK
Ensembl hg19 (Hinxton)ENSG00000115956 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115956 [Gene_View]  chr2:68365190-68397453 [Contig_View]  PLEK [Vega]
ICGC DataPortalENSG00000115956
TCGA cBioPortalPLEK
AceView (NCBI)PLEK
Genatlas (Paris)PLEK
WikiGenes5341
SOURCE (Princeton)PLEK
Genetics Home Reference (NIH)PLEK
Genomic and cartography
GoldenPath hg38 (UCSC)PLEK  -     chr2:68365190-68397453 +  2p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEK  -     2p14   [Description]    (hg19-Feb_2009)
EnsemblPLEK - 2p14 [CytoView hg19]  PLEK - 2p14 [CytoView hg38]
Mapping of homologs : NCBIPLEK [Mapview hg19]  PLEK [Mapview hg38]
OMIM173570   
Gene and transcription
Genbank (Entrez)AB208967 AK124424 AK130678 AK313756 BC018549
RefSeq transcript (Entrez)NM_002664
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEK
Cluster EST : UnigeneHs.468840 [ NCBI ]
CGAP (NCI)Hs.468840
Alternative Splicing GalleryENSG00000115956
Gene ExpressionPLEK [ NCBI-GEO ]   PLEK [ EBI - ARRAY_EXPRESS ]   PLEK [ SEEK ]   PLEK [ MEM ]
Gene Expression Viewer (FireBrowse)PLEK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5341
GTEX Portal (Tissue expression)PLEK
Human Protein AtlasENSG00000115956-PLEK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08567   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08567  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08567
Splice isoforms : SwissVarP08567
PhosPhoSitePlusP08567
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DEP_dom    PH_dom-like    PH_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam00610    pfam00169   
Domain families : Smart (EMBL)DEP (SM00049)  PH (SM00233)  
Conserved Domain (NCBI)PLEK
DMDM Disease mutations5341
Blocks (Seattle)PLEK
PDB (SRS)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
PDB (PDBSum)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
PDB (IMB)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
PDB (RSDB)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
Structural Biology KnowledgeBase1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
SCOP (Structural Classification of Proteins)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
CATH (Classification of proteins structures)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
SuperfamilyP08567
Human Protein Atlas [tissue]ENSG00000115956-PLEK [tissue]
Peptide AtlasP08567
HPRD15935
IPIIPI00306311   IPI00742980   
Protein Interaction databases
DIP (DOE-UCLA)P08567
IntAct (EBI)P08567
FunCoupENSG00000115956
BioGRIDPLEK
STRING (EMBL)PLEK
ZODIACPLEK
Ontologies - Pathways
QuickGOP08567
Ontology : AmiGOhematopoietic progenitor cell differentiation  platelet degranulation  platelet degranulation  protein kinase C binding  protein binding  extracellular region  cytoplasm  cytosol  vesicle docking involved in exocytosis  integrin-mediated signaling pathway  positive regulation of platelet activation  negative regulation of inositol phosphate biosynthetic process  positive regulation of inositol-polyphosphate 5-phosphatase activity  membrane  cell projection organization  positive regulation of actin filament depolymerization  phospholipase C-inhibiting G-protein coupled receptor signaling pathway  cortical actin cytoskeleton organization  ruffle organization  actin cytoskeleton reorganization  positive regulation of actin filament bundle assembly  ruffle membrane  positive regulation of integrin activation  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  negative regulation of G-protein coupled receptor protein signaling pathway  phosphatidylinositol metabolic process  negative regulation of calcium-mediated signaling  regulation of cell diameter  thrombin-activated receptor signaling pathway  platelet aggregation  platelet aggregation  protein kinase C signaling  protein secretion by platelet  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  platelet degranulation  platelet degranulation  protein kinase C binding  protein binding  extracellular region  cytoplasm  cytosol  vesicle docking involved in exocytosis  integrin-mediated signaling pathway  positive regulation of platelet activation  negative regulation of inositol phosphate biosynthetic process  positive regulation of inositol-polyphosphate 5-phosphatase activity  membrane  cell projection organization  positive regulation of actin filament depolymerization  phospholipase C-inhibiting G-protein coupled receptor signaling pathway  cortical actin cytoskeleton organization  ruffle organization  actin cytoskeleton reorganization  positive regulation of actin filament bundle assembly  ruffle membrane  positive regulation of integrin activation  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  negative regulation of G-protein coupled receptor protein signaling pathway  phosphatidylinositol metabolic process  negative regulation of calcium-mediated signaling  regulation of cell diameter  thrombin-activated receptor signaling pathway  platelet aggregation  platelet aggregation  protein kinase C signaling  protein secretion by platelet  
NDEx NetworkPLEK
Atlas of Cancer Signalling NetworkPLEK
Wikipedia pathwaysPLEK
Orthology - Evolution
OrthoDB5341
GeneTree (enSembl)ENSG00000115956
Phylogenetic Trees/Animal Genes : TreeFamPLEK
HOVERGENP08567
HOGENOMP08567
Homologs : HomoloGenePLEK
Homology/Alignments : Family Browser (UCSC)PLEK
Gene fusions - Rearrangements
Tumor Fusion PortalPLEK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEK
dbVarPLEK
ClinVarPLEK
1000_GenomesPLEK 
Exome Variant ServerPLEK
ExAC (Exome Aggregation Consortium)ENSG00000115956
GNOMAD BrowserENSG00000115956
Genetic variants : HAPMAP5341
Genomic Variants (DGV)PLEK [DGVbeta]
DECIPHERPLEK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEK 
Mutations
ICGC Data PortalPLEK 
TCGA Data PortalPLEK 
Broad Tumor PortalPLEK
OASIS PortalPLEK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEK
DgiDB (Drug Gene Interaction Database)PLEK
DoCM (Curated mutations)PLEK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEK (select a term)
intoGenPLEK
Cancer3DPLEK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173570   
Orphanet
DisGeNETPLEK
MedgenPLEK
Genetic Testing Registry PLEK
NextProtP08567 [Medical]
TSGene5341
GENETestsPLEK
Target ValidationPLEK
Huge Navigator PLEK [HugePedia]
snp3D : Map Gene to Disease5341
BioCentury BCIQPLEK
ClinGenPLEK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5341
Chemical/Pharm GKB GenePA33400
Clinical trialPLEK
Miscellaneous
canSAR (ICR)PLEK (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEK
EVEXPLEK
GoPubMedPLEK
iHOPPLEK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:07 CET 2017

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