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PLEK (pleckstrin)

Identity

Alias (NCBI)P47
HGNC (Hugo) PLEK
HGNC Alias symbP47
LocusID (NCBI) 5341
Atlas_Id 46495
Location 2p14  [Link to chromosome band 2p14]
Location_base_pair Starts at 68365282 and ends at 68397453 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLEK (2p14) / PLEK (2p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;7)(p14;p15) PLEK/HOXA11-AS


External links

 

Nomenclature
HGNC (Hugo)PLEK   9070
Cards
Entrez_Gene (NCBI)PLEK    pleckstrin
AliasesP47
GeneCards (Weizmann)PLEK
Ensembl hg19 (Hinxton)ENSG00000115956 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115956 [Gene_View]  ENSG00000115956 [Sequence]  chr2:68365282-68397453 [Contig_View]  PLEK [Vega]
ICGC DataPortalENSG00000115956
TCGA cBioPortalPLEK
AceView (NCBI)PLEK
Genatlas (Paris)PLEK
SOURCE (Princeton)PLEK
Genetics Home Reference (NIH)PLEK
Genomic and cartography
GoldenPath hg38 (UCSC)PLEK  -     chr2:68365282-68397453 +  2p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEK  -     2p14   [Description]    (hg19-Feb_2009)
GoldenPathPLEK - 2p14 [CytoView hg19]  PLEK - 2p14 [CytoView hg38]
ImmunoBaseENSG00000115956
Genome Data Viewer NCBIPLEK [Mapview hg19]  
OMIM173570   
Gene and transcription
Genbank (Entrez)AB208967 AK124424 AK130678 AK313756 BC018549
RefSeq transcript (Entrez)NM_002664
Consensus coding sequences : CCDS (NCBI)PLEK
Gene ExpressionPLEK [ NCBI-GEO ]   PLEK [ EBI - ARRAY_EXPRESS ]   PLEK [ SEEK ]   PLEK [ MEM ]
Gene Expression Viewer (FireBrowse)PLEK [ Firebrowse - Broad ]
GenevisibleExpression of PLEK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5341
GTEX Portal (Tissue expression)PLEK
Human Protein AtlasENSG00000115956-PLEK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08567   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08567  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08567
PhosPhoSitePlusP08567
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DEP_dom    PH-like_dom_sf    PH_domain    PLEK1_DEP    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEP (PF00610)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam00610    pfam00169   
Domain families : Smart (EMBL)DEP (SM00049)  PH (SM00233)  
Conserved Domain (NCBI)PLEK
PDB (RSDB)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
PDB Europe1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
PDB (PDBSum)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
PDB (IMB)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
Structural Biology KnowledgeBase1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
SCOP (Structural Classification of Proteins)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
CATH (Classification of proteins structures)1PLS    1W4M    1X05    1XX0    1ZM0    2CSO    2I5C    2I5F   
SuperfamilyP08567
AlphaFold pdb e-kbP08567   
Human Protein Atlas [tissue]ENSG00000115956-PLEK [tissue]
HPRD15935
Protein Interaction databases
DIP (DOE-UCLA)P08567
IntAct (EBI)P08567
BioGRIDPLEK
STRING (EMBL)PLEK
ZODIACPLEK
Ontologies - Pathways
QuickGOP08567
Ontology : AmiGOhematopoietic progenitor cell differentiation  platelet degranulation  platelet degranulation  protein kinase C binding  protein binding  extracellular region  cytoplasm  cytosol  plasma membrane  vesicle docking involved in exocytosis  integrin-mediated signaling pathway  positive regulation of platelet activation  negative regulation of inositol phosphate biosynthetic process  positive regulation of inositol-polyphosphate 5-phosphatase activity  membrane  cell projection organization  positive regulation of actin filament depolymerization  phospholipase C-inhibiting G protein-coupled receptor signaling pathway  cortical actin cytoskeleton organization  ruffle organization  actin cytoskeleton reorganization  actin cytoskeleton reorganization  positive regulation of actin filament bundle assembly  ruffle membrane  positive regulation of integrin activation  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  negative regulation of G protein-coupled receptor signaling pathway  phosphatidylinositol metabolic process  negative regulation of calcium-mediated signaling  regulation of cell diameter  thrombin-activated receptor signaling pathway  platelet aggregation  platelet aggregation  protein kinase C signaling  protein secretion by platelet  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  platelet degranulation  platelet degranulation  protein kinase C binding  protein binding  extracellular region  cytoplasm  cytosol  plasma membrane  vesicle docking involved in exocytosis  integrin-mediated signaling pathway  positive regulation of platelet activation  negative regulation of inositol phosphate biosynthetic process  positive regulation of inositol-polyphosphate 5-phosphatase activity  membrane  cell projection organization  positive regulation of actin filament depolymerization  phospholipase C-inhibiting G protein-coupled receptor signaling pathway  cortical actin cytoskeleton organization  ruffle organization  actin cytoskeleton reorganization  actin cytoskeleton reorganization  positive regulation of actin filament bundle assembly  ruffle membrane  positive regulation of integrin activation  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  negative regulation of G protein-coupled receptor signaling pathway  phosphatidylinositol metabolic process  negative regulation of calcium-mediated signaling  regulation of cell diameter  thrombin-activated receptor signaling pathway  platelet aggregation  platelet aggregation  protein kinase C signaling  protein secretion by platelet  
NDEx NetworkPLEK
Atlas of Cancer Signalling NetworkPLEK
Wikipedia pathwaysPLEK
Orthology - Evolution
OrthoDB5341
GeneTree (enSembl)ENSG00000115956
Phylogenetic Trees/Animal Genes : TreeFamPLEK
Homologs : HomoloGenePLEK
Homology/Alignments : Family Browser (UCSC)PLEK
Gene fusions - Rearrangements
Fusion : QuiverPLEK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEK
dbVarPLEK
ClinVarPLEK
MonarchPLEK
1000_GenomesPLEK 
Exome Variant ServerPLEK
GNOMAD BrowserENSG00000115956
Varsome BrowserPLEK
ACMGPLEK variants
VarityP08567
Genomic Variants (DGV)PLEK [DGVbeta]
DECIPHERPLEK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEK 
Mutations
ICGC Data PortalPLEK 
TCGA Data PortalPLEK 
Broad Tumor PortalPLEK
OASIS PortalPLEK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLEK
Mutations and Diseases : HGMDPLEK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLEK
DgiDB (Drug Gene Interaction Database)PLEK
DoCM (Curated mutations)PLEK
CIViC (Clinical Interpretations of Variants in Cancer)PLEK
Cancer3DPLEK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173570   
Orphanet
DisGeNETPLEK
MedgenPLEK
Genetic Testing Registry PLEK
NextProtP08567 [Medical]
GENETestsPLEK
Target ValidationPLEK
Huge Navigator PLEK [HugePedia]
ClinGenPLEK
Clinical trials, drugs, therapy
MyCancerGenomePLEK
Protein Interactions : CTDPLEK
Pharm GKB GenePA33400
PharosP08567
Clinical trialPLEK
Miscellaneous
canSAR (ICR)PLEK
HarmonizomePLEK
DataMed IndexPLEK
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLEK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:25:39 CEST 2021

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