PLEK2 (pleckstrin 2)

2011-11-01  

Identity

HGNC
LOCATION
14q23.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 26499
MIM: 608007
HGNC: 19238
Ensembl: ENSG00000100558

Variants:

dbSNP: 26499
ClinVar: 26499
TCGA: ENSG00000100558
COSMIC: PLEK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100558ENST00000216446Q9NYT0
ENSG00000100558ENST00000553387G3V337
ENSG00000100558ENST00000554395H0YJ64
ENSG00000100558ENST00000555803H0YJD0
ENSG00000100558ENST00000556532H0YIZ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216982442011Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma.8
170085422007PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.7
176584642007Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading.4
311821362019PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.3
314988912020PLEK2 mediates metastasis and vascular invasion via the ubiquitin-dependent degradation of SHIP2 in non-small cell lung cancer.1
158652082005Cloning, expression and chromosomal assignment of human pleckstrin 2.0

Citation

Dessen P

PLEK2 (pleckstrin 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52493/plek2