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PLEK2 (pleckstrin 2)

Identity

Other alias-
HGNC (Hugo) PLEK2
LocusID (NCBI) 26499
Atlas_Id 52493
Location 14q23.3  [Link to chromosome band 14q23]
Location_base_pair Starts at 67386979 and ends at 67412200 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TMEM94 (17q25.1) / PLEK2 (14q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEK2   19238
Cards
Entrez_Gene (NCBI)PLEK2  26499  pleckstrin 2
Aliases
GeneCards (Weizmann)PLEK2
Ensembl hg19 (Hinxton)ENSG00000100558 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100558 [Gene_View]  chr14:67386979-67412200 [Contig_View]  PLEK2 [Vega]
ICGC DataPortalENSG00000100558
TCGA cBioPortalPLEK2
AceView (NCBI)PLEK2
Genatlas (Paris)PLEK2
WikiGenes26499
SOURCE (Princeton)PLEK2
Genetics Home Reference (NIH)PLEK2
Genomic and cartography
GoldenPath hg38 (UCSC)PLEK2  -     chr14:67386979-67412200 -  14q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEK2  -     14q23.3   [Description]    (hg19-Feb_2009)
EnsemblPLEK2 - 14q23.3 [CytoView hg19]  PLEK2 - 14q23.3 [CytoView hg38]
Mapping of homologs : NCBIPLEK2 [Mapview hg19]  PLEK2 [Mapview hg38]
OMIM608007   
Gene and transcription
Genbank (Entrez)AF228603 BC001226 BC008056 BX114063 CR976852
RefSeq transcript (Entrez)NM_016445
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEK2
Cluster EST : UnigeneHs.170473 [ NCBI ]
CGAP (NCI)Hs.170473
Alternative Splicing GalleryENSG00000100558
Gene ExpressionPLEK2 [ NCBI-GEO ]   PLEK2 [ EBI - ARRAY_EXPRESS ]   PLEK2 [ SEEK ]   PLEK2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26499
GTEX Portal (Tissue expression)PLEK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYT0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYT0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYT0
Splice isoforms : SwissVarQ9NYT0
PhosPhoSitePlusQ9NYT0
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DEP_dom    PH_dom-like    PH_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam00610    pfam00169   
Domain families : Smart (EMBL)DEP (SM00049)  PH (SM00233)  
Conserved Domain (NCBI)PLEK2
DMDM Disease mutations26499
Blocks (Seattle)PLEK2
PDB (SRS)1X1G   
PDB (PDBSum)1X1G   
PDB (IMB)1X1G   
PDB (RSDB)1X1G   
Structural Biology KnowledgeBase1X1G   
SCOP (Structural Classification of Proteins)1X1G   
CATH (Classification of proteins structures)1X1G   
SuperfamilyQ9NYT0
Human Protein AtlasENSG00000100558
Peptide AtlasQ9NYT0
HPRD12151
IPIIPI00009302   IPI01025718   IPI01025488   IPI01025592   IPI01025234   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYT0
IntAct (EBI)Q9NYT0
FunCoupENSG00000100558
BioGRIDPLEK2
STRING (EMBL)PLEK2
ZODIACPLEK2
Ontologies - Pathways
QuickGOQ9NYT0
Ontology : AmiGOcytoplasm  cytoskeleton  actin cytoskeleton organization  lamellipodium membrane  intracellular signal transduction  
Ontology : EGO-EBIcytoplasm  cytoskeleton  actin cytoskeleton organization  lamellipodium membrane  intracellular signal transduction  
NDEx NetworkPLEK2
Atlas of Cancer Signalling NetworkPLEK2
Wikipedia pathwaysPLEK2
Orthology - Evolution
OrthoDB26499
GeneTree (enSembl)ENSG00000100558
Phylogenetic Trees/Animal Genes : TreeFamPLEK2
HOVERGENQ9NYT0
HOGENOMQ9NYT0
Homologs : HomoloGenePLEK2
Homology/Alignments : Family Browser (UCSC)PLEK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEK2
dbVarPLEK2
ClinVarPLEK2
1000_GenomesPLEK2 
Exome Variant ServerPLEK2
ExAC (Exome Aggregation Consortium)PLEK2 (select the gene name)
Genetic variants : HAPMAP26499
Genomic Variants (DGV)PLEK2 [DGVbeta]
DECIPHERPLEK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEK2 
Mutations
ICGC Data PortalPLEK2 
TCGA Data PortalPLEK2 
Broad Tumor PortalPLEK2
OASIS PortalPLEK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEK2
DgiDB (Drug Gene Interaction Database)PLEK2
DoCM (Curated mutations)PLEK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEK2 (select a term)
intoGenPLEK2
Cancer3DPLEK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608007   
Orphanet
MedgenPLEK2
Genetic Testing Registry PLEK2
NextProtQ9NYT0 [Medical]
TSGene26499
GENETestsPLEK2
Target ValidationPLEK2
Huge Navigator PLEK2 [HugePedia]
snp3D : Map Gene to Disease26499
BioCentury BCIQPLEK2
ClinGenPLEK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26499
Chemical/Pharm GKB GenePA134963543
Clinical trialPLEK2
Miscellaneous
canSAR (ICR)PLEK2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEK2
EVEXPLEK2
GoPubMedPLEK2
iHOPPLEK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:53 CEST 2017

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