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PLEKHA2 (pleckstrin homology domain containing A2)

Identity

Alias_namespleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
Alias_symbol (synonym)TAPP2
Other alias
HGNC (Hugo) PLEKHA2
LocusID (NCBI) 59339
Atlas_Id 51258
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 38901235 and ends at 38973911 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HOOK3 (8p11.21) / PLEKHA2 (8p11.22)LHFP (13q13.3) / PLEKHA2 (8p11.22)NOL3 (16q22.1) / PLEKHA2 (8p11.22)
PARD3 (10p11.22) / PLEKHA2 (8p11.22)PLEKHA2 (8p11.22) / ISLR (15q24.1)PLEKHA2 (8p11.22) / KCNU1 (8p11.23)
PLEKHA2 (8p11.22) / LHFP (13q13.3)PLEKHA2 (8p11.22) / OSBPL11 (3q21.2)WHSC1L1 (8p11.23) / PLEKHA2 (8p11.22)
HOOK3 8p11.21 / PLEKHA2 8p11.22PLEKHA2 8p11.22 / KCNU1 8p11.23WHSC1L1 8p11.23 / PLEKHA2 8p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEKHA2   14336
Cards
Entrez_Gene (NCBI)PLEKHA2  59339  pleckstrin homology domain containing A2
AliasesTAPP2
GeneCards (Weizmann)PLEKHA2
Ensembl hg19 (Hinxton)ENSG00000169499 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169499 [Gene_View]  chr8:38901235-38973911 [Contig_View]  PLEKHA2 [Vega]
ICGC DataPortalENSG00000169499
TCGA cBioPortalPLEKHA2
AceView (NCBI)PLEKHA2
Genatlas (Paris)PLEKHA2
WikiGenes59339
SOURCE (Princeton)PLEKHA2
Genetics Home Reference (NIH)PLEKHA2
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHA2  -     chr8:38901235-38973911 +  8p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHA2  -     8p11.22   [Description]    (hg19-Feb_2009)
EnsemblPLEKHA2 - 8p11.22 [CytoView hg19]  PLEKHA2 - 8p11.22 [CytoView hg38]
Mapping of homologs : NCBIPLEKHA2 [Mapview hg19]  PLEKHA2 [Mapview hg38]
OMIM607773   
Gene and transcription
Genbank (Entrez)AA985353 AF286164 AK057205 AK098787 AK291842
RefSeq transcript (Entrez)NM_021623
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEKHA2
Cluster EST : UnigeneHs.369123 [ NCBI ]
CGAP (NCI)Hs.369123
Alternative Splicing GalleryENSG00000169499
Gene ExpressionPLEKHA2 [ NCBI-GEO ]   PLEKHA2 [ EBI - ARRAY_EXPRESS ]   PLEKHA2 [ SEEK ]   PLEKHA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59339
GTEX Portal (Tissue expression)PLEKHA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HB19   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HB19  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HB19
Splice isoforms : SwissVarQ9HB19
PhosPhoSitePlusQ9HB19
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)PH (PF00169)   
Domain families : Pfam (NCBI)pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)PLEKHA2
DMDM Disease mutations59339
Blocks (Seattle)PLEKHA2
SuperfamilyQ9HB19
Human Protein AtlasENSG00000169499
Peptide AtlasQ9HB19
IPIIPI00455835   IPI01011869   IPI00983450   
Protein Interaction databases
DIP (DOE-UCLA)Q9HB19
IntAct (EBI)Q9HB19
FunCoupENSG00000169499
BioGRIDPLEKHA2
STRING (EMBL)PLEKHA2
ZODIACPLEKHA2
Ontologies - Pathways
QuickGOQ9HB19
Ontology : AmiGOpositive regulation of cell-matrix adhesion  fibronectin binding  protein binding  nucleus  cytoplasm  plasma membrane  phosphatidylinositol biosynthetic process  membrane  PDZ domain binding  phosphatidylinositol binding  protein complex  laminin binding  
Ontology : EGO-EBIpositive regulation of cell-matrix adhesion  fibronectin binding  protein binding  nucleus  cytoplasm  plasma membrane  phosphatidylinositol biosynthetic process  membrane  PDZ domain binding  phosphatidylinositol binding  protein complex  laminin binding  
NDEx NetworkPLEKHA2
Atlas of Cancer Signalling NetworkPLEKHA2
Wikipedia pathwaysPLEKHA2
Orthology - Evolution
OrthoDB59339
GeneTree (enSembl)ENSG00000169499
Phylogenetic Trees/Animal Genes : TreeFamPLEKHA2
HOVERGENQ9HB19
HOGENOMQ9HB19
Homologs : HomoloGenePLEKHA2
Homology/Alignments : Family Browser (UCSC)PLEKHA2
Gene fusions - Rearrangements
Fusion : MitelmanHOOK3/PLEKHA2 [8p11.21/8p11.22]  [t(8;8)(p11;p11)]  
Fusion : MitelmanPLEKHA2/KCNU1 [8p11.22/8p11.23]  [t(8;8)(p11;p11)]  
Fusion : MitelmanPLEKHA2/OSBPL11 [8p11.22/3q21.2]  [t(3;8)(q21;p11)]  
Fusion : MitelmanWHSC1L1/PLEKHA2 [8p11.23/8p11.22]  [t(8;8)(p11;p12)]  
Fusion: TCGAHOOK3 8p11.21 PLEKHA2 8p11.22 BRCA
Fusion: TCGAPLEKHA2 8p11.22 KCNU1 8p11.23 BRCA
Fusion: TCGAWHSC1L1 8p11.23 PLEKHA2 8p11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHA2
dbVarPLEKHA2
ClinVarPLEKHA2
1000_GenomesPLEKHA2 
Exome Variant ServerPLEKHA2
ExAC (Exome Aggregation Consortium)PLEKHA2 (select the gene name)
Genetic variants : HAPMAP59339
Genomic Variants (DGV)PLEKHA2 [DGVbeta]
DECIPHERPLEKHA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHA2 
Mutations
ICGC Data PortalPLEKHA2 
TCGA Data PortalPLEKHA2 
Broad Tumor PortalPLEKHA2
OASIS PortalPLEKHA2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLEKHA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHA2
DgiDB (Drug Gene Interaction Database)PLEKHA2
DoCM (Curated mutations)PLEKHA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHA2 (select a term)
intoGenPLEKHA2
Cancer3DPLEKHA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607773   
Orphanet
MedgenPLEKHA2
Genetic Testing Registry PLEKHA2
NextProtQ9HB19 [Medical]
TSGene59339
GENETestsPLEKHA2
Target ValidationPLEKHA2
Huge Navigator PLEKHA2 [HugePedia]
snp3D : Map Gene to Disease59339
BioCentury BCIQPLEKHA2
ClinGenPLEKHA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59339
Chemical/Pharm GKB GenePA33402
Clinical trialPLEKHA2
Miscellaneous
canSAR (ICR)PLEKHA2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHA2
EVEXPLEKHA2
GoPubMedPLEKHA2
iHOPPLEKHA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:53 CEST 2017

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