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PLEKHA2 (pleckstrin homology domain containing A2)

Identity

Alias (NCBI)TAPP2
HGNC (Hugo) PLEKHA2
HGNC Alias symbTAPP2
HGNC Alias nametandem PH Domain containing protein-2
HGNC Previous namepleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
LocusID (NCBI) 59339
Atlas_Id 51258
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 38901346 and ends at 38973911 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HOOK3 (8p11.21) / PLEKHA2 (8p11.22)LHFP (13q13.3) / PLEKHA2 (8p11.22)NOL3 (16q22.1) / PLEKHA2 (8p11.22)
PARD3 (10p11.22) / PLEKHA2 (8p11.22)PLEKHA2 (8p11.22) / ISLR (15q24.1)PLEKHA2 (8p11.22) / KCNU1 (8p11.23)
PLEKHA2 (8p11.22) / LHFP (13q13.3)PLEKHA2 (8p11.22) / OSBPL11 (3q21.2)WHSC1L1 (8p11.23) / PLEKHA2 (8p11.22)
HOOK3 8p11.21 / PLEKHA2 8p11.22PLEKHA2 8p11.22 / KCNU1 8p11.23WHSC1L1 8p11.23 / PLEKHA2 8p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLEKHA2   14336
Cards
Entrez_Gene (NCBI)PLEKHA2    pleckstrin homology domain containing A2
AliasesTAPP2
GeneCards (Weizmann)PLEKHA2
Ensembl hg19 (Hinxton)ENSG00000169499 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169499 [Gene_View]  ENSG00000169499 [Sequence]  chr8:38901346-38973911 [Contig_View]  PLEKHA2 [Vega]
ICGC DataPortalENSG00000169499
TCGA cBioPortalPLEKHA2
AceView (NCBI)PLEKHA2
Genatlas (Paris)PLEKHA2
SOURCE (Princeton)PLEKHA2
Genetics Home Reference (NIH)PLEKHA2
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHA2  -     chr8:38901346-38973911 +  8p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHA2  -     8p11.22   [Description]    (hg19-Feb_2009)
GoldenPathPLEKHA2 - 8p11.22 [CytoView hg19]  PLEKHA2 - 8p11.22 [CytoView hg38]
ImmunoBaseENSG00000169499
Genome Data Viewer NCBIPLEKHA2 [Mapview hg19]  
OMIM607773   
Gene and transcription
Genbank (Entrez)AA985353 AF286164 AK057205 AK098787 AK291842
RefSeq transcript (Entrez)NM_021623
Consensus coding sequences : CCDS (NCBI)PLEKHA2
Gene ExpressionPLEKHA2 [ NCBI-GEO ]   PLEKHA2 [ EBI - ARRAY_EXPRESS ]   PLEKHA2 [ SEEK ]   PLEKHA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHA2 [ Firebrowse - Broad ]
GenevisibleExpression of PLEKHA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59339
GTEX Portal (Tissue expression)PLEKHA2
Human Protein AtlasENSG00000169499-PLEKHA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HB19   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HB19  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HB19
PhosPhoSitePlusQ9HB19
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)PH (PF00169)   
Domain families : Pfam (NCBI)pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)PLEKHA2
SuperfamilyQ9HB19
AlphaFold pdb e-kbQ9HB19   
Human Protein Atlas [tissue]ENSG00000169499-PLEKHA2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9HB19
IntAct (EBI)Q9HB19
BioGRIDPLEKHA2
STRING (EMBL)PLEKHA2
ZODIACPLEKHA2
Ontologies - Pathways
QuickGOQ9HB19
Ontology : AmiGOpositive regulation of cell-matrix adhesion  fibronectin binding  protein binding  nucleus  cytoplasm  cytoplasm  plasma membrane  phosphatidylinositol biosynthetic process  lipid binding  membrane  membrane  PDZ domain binding  protein-containing complex  laminin binding  phosphatidylinositol-3,4-bisphosphate binding  
Ontology : EGO-EBIpositive regulation of cell-matrix adhesion  fibronectin binding  protein binding  nucleus  cytoplasm  cytoplasm  plasma membrane  phosphatidylinositol biosynthetic process  lipid binding  membrane  membrane  PDZ domain binding  protein-containing complex  laminin binding  phosphatidylinositol-3,4-bisphosphate binding  
NDEx NetworkPLEKHA2
Atlas of Cancer Signalling NetworkPLEKHA2
Wikipedia pathwaysPLEKHA2
Orthology - Evolution
OrthoDB59339
GeneTree (enSembl)ENSG00000169499
Phylogenetic Trees/Animal Genes : TreeFamPLEKHA2
Homologs : HomoloGenePLEKHA2
Homology/Alignments : Family Browser (UCSC)PLEKHA2
Gene fusions - Rearrangements
Fusion : MitelmanHOOK3/PLEKHA2 [8p11.21/8p11.22]  
Fusion : MitelmanPLEKHA2/KCNU1 [8p11.22/8p11.23]  
Fusion : MitelmanPLEKHA2/OSBPL11 [8p11.22/3q21.2]  
Fusion : MitelmanWHSC1L1/PLEKHA2 [8p11.23/8p11.22]  
Fusion : QuiverPLEKHA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHA2
dbVarPLEKHA2
ClinVarPLEKHA2
MonarchPLEKHA2
1000_GenomesPLEKHA2 
Exome Variant ServerPLEKHA2
GNOMAD BrowserENSG00000169499
Varsome BrowserPLEKHA2
ACMGPLEKHA2 variants
VarityQ9HB19
Genomic Variants (DGV)PLEKHA2 [DGVbeta]
DECIPHERPLEKHA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHA2 
Mutations
ICGC Data PortalPLEKHA2 
TCGA Data PortalPLEKHA2 
Broad Tumor PortalPLEKHA2
OASIS PortalPLEKHA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLEKHA2
Mutations and Diseases : HGMDPLEKHA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLEKHA2
DgiDB (Drug Gene Interaction Database)PLEKHA2
DoCM (Curated mutations)PLEKHA2
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHA2
Cancer3DPLEKHA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607773   
Orphanet
DisGeNETPLEKHA2
MedgenPLEKHA2
Genetic Testing Registry PLEKHA2
NextProtQ9HB19 [Medical]
GENETestsPLEKHA2
Target ValidationPLEKHA2
Huge Navigator PLEKHA2 [HugePedia]
ClinGenPLEKHA2
Clinical trials, drugs, therapy
MyCancerGenomePLEKHA2
Protein Interactions : CTDPLEKHA2
Pharm GKB GenePA33402
PharosQ9HB19
Clinical trialPLEKHA2
Miscellaneous
canSAR (ICR)PLEKHA2
HarmonizomePLEKHA2
DataMed IndexPLEKHA2
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLEKHA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:39 CEST 2021

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