Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PLEKHB2 (pleckstrin homology domain containing B2)

Identity

Alias_namespleckstrin homology domain containing
Alias_symbol (synonym)EVT2
FLJ20783
Other alias
HGNC (Hugo) PLEKHB2
LocusID (NCBI) 55041
Atlas_Id 54542
Location 2q21.1  [Link to chromosome band 2q21]
Location_base_pair Starts at 131104847 and ends at 131149852 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
P4HB (17q25.3) / PLEKHB2 (2q21.1)PLEKHB2 (2q21.1) / ARHGEF4 (2q21.1)PLEKHB2 (2q21.1) / FAM168B (2q21.1)
PLEKHB2 2q21.1 / FAM168B 2q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEKHB2   19236
Cards
Entrez_Gene (NCBI)PLEKHB2  55041  pleckstrin homology domain containing B2
AliasesEVT2
GeneCards (Weizmann)PLEKHB2
Ensembl hg19 (Hinxton)ENSG00000115762 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115762 [Gene_View]  chr2:131104847-131149852 [Contig_View]  PLEKHB2 [Vega]
ICGC DataPortalENSG00000115762
TCGA cBioPortalPLEKHB2
AceView (NCBI)PLEKHB2
Genatlas (Paris)PLEKHB2
WikiGenes55041
SOURCE (Princeton)PLEKHB2
Genetics Home Reference (NIH)PLEKHB2
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHB2  -     chr2:131104847-131149852 +  2q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHB2  -     2q21.1   [Description]    (hg19-Feb_2009)
EnsemblPLEKHB2 - 2q21.1 [CytoView hg19]  PLEKHB2 - 2q21.1 [CytoView hg38]
Mapping of homologs : NCBIPLEKHB2 [Mapview hg19]  PLEKHB2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI458777 AK000790 AK054998 AK074259 AK093730
RefSeq transcript (Entrez)NM_001031706 NM_001100623 NM_001267062 NM_001267063 NM_001267064 NM_001267065 NM_001267066 NM_001267067 NM_001267068 NM_001309448 NM_001309450 NM_001309451 NM_001309452 NM_017958
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEKHB2
Cluster EST : UnigeneHs.708368 [ NCBI ]
CGAP (NCI)Hs.708368
Alternative Splicing GalleryENSG00000115762
Gene ExpressionPLEKHB2 [ NCBI-GEO ]   PLEKHB2 [ EBI - ARRAY_EXPRESS ]   PLEKHB2 [ SEEK ]   PLEKHB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55041
GTEX Portal (Tissue expression)PLEKHB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96CS7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96CS7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96CS7
Splice isoforms : SwissVarQ96CS7
PhosPhoSitePlusQ96CS7
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)PH (PF00169)   
Domain families : Pfam (NCBI)pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)PLEKHB2
DMDM Disease mutations55041
Blocks (Seattle)PLEKHB2
PDB (SRS)3AJ4    3VIA   
PDB (PDBSum)3AJ4    3VIA   
PDB (IMB)3AJ4    3VIA   
PDB (RSDB)3AJ4    3VIA   
Structural Biology KnowledgeBase3AJ4    3VIA   
SCOP (Structural Classification of Proteins)3AJ4    3VIA   
CATH (Classification of proteins structures)3AJ4    3VIA   
SuperfamilyQ96CS7
Human Protein AtlasENSG00000115762
Peptide AtlasQ96CS7
HPRD15144
IPIIPI00335457   IPI00031228   IPI00409715   IPI00910356   IPI01014500   IPI00910827   IPI00921266   IPI00917586   
Protein Interaction databases
DIP (DOE-UCLA)Q96CS7
IntAct (EBI)Q96CS7
FunCoupENSG00000115762
BioGRIDPLEKHB2
STRING (EMBL)PLEKHB2
ZODIACPLEKHB2
Ontologies - Pathways
QuickGOQ96CS7
Ontology : AmiGOprotein binding  integral component of membrane  regulation of cell differentiation  recycling endosome membrane  
Ontology : EGO-EBIprotein binding  integral component of membrane  regulation of cell differentiation  recycling endosome membrane  
NDEx NetworkPLEKHB2
Atlas of Cancer Signalling NetworkPLEKHB2
Wikipedia pathwaysPLEKHB2
Orthology - Evolution
OrthoDB55041
GeneTree (enSembl)ENSG00000115762
Phylogenetic Trees/Animal Genes : TreeFamPLEKHB2
HOVERGENQ96CS7
HOGENOMQ96CS7
Homologs : HomoloGenePLEKHB2
Homology/Alignments : Family Browser (UCSC)PLEKHB2
Gene fusions - Rearrangements
Fusion : MitelmanPLEKHB2/ARHGEF4 [2q21.1/2q21.1]  
Fusion : MitelmanPLEKHB2/FAM168B [2q21.1/2q21.1]  [t(2;2)(q21;q22)]  
Fusion: TCGAPLEKHB2 2q21.1 FAM168B 2q21.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHB2
dbVarPLEKHB2
ClinVarPLEKHB2
1000_GenomesPLEKHB2 
Exome Variant ServerPLEKHB2
ExAC (Exome Aggregation Consortium)PLEKHB2 (select the gene name)
Genetic variants : HAPMAP55041
Genomic Variants (DGV)PLEKHB2 [DGVbeta]
DECIPHERPLEKHB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHB2 
Mutations
ICGC Data PortalPLEKHB2 
TCGA Data PortalPLEKHB2 
Broad Tumor PortalPLEKHB2
OASIS PortalPLEKHB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEKHB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHB2
DgiDB (Drug Gene Interaction Database)PLEKHB2
DoCM (Curated mutations)PLEKHB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHB2 (select a term)
intoGenPLEKHB2
Cancer3DPLEKHB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPLEKHB2
Genetic Testing Registry PLEKHB2
NextProtQ96CS7 [Medical]
TSGene55041
GENETestsPLEKHB2
Target ValidationPLEKHB2
Huge Navigator PLEKHB2 [HugePedia]
snp3D : Map Gene to Disease55041
BioCentury BCIQPLEKHB2
ClinGenPLEKHB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55041
Chemical/Pharm GKB GenePA134885873
Clinical trialPLEKHB2
Miscellaneous
canSAR (ICR)PLEKHB2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHB2
EVEXPLEKHB2
GoPubMedPLEKHB2
iHOPPLEKHB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:49:51 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.