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PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1)

Identity

Alias (NCBI)ARHGEF41
HGNC (Hugo) PLEKHG1
HGNC Alias symbKIAA1209
ARHGEF41
HGNC Previous namepleckstrin homology domain containing, family G (with RhoGef domain) member 1
LocusID (NCBI) 57480
Atlas_Id 71978
Location 6q25.1  [Link to chromosome band 6q25]
Location_base_pair Starts at 150721099 and ends at 150843665 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID1B (6q25.3) / PLEKHG1 (6q25.1)CCDC28B (1p35.1) / PLEKHG1 (6q25.1)COQ9 (16q21) / PLEKHG1 (6q25.1)
MTHFD1L (6q25.1) / PLEKHG1 (6q25.1)MYO1B (2q32.3) / PLEKHG1 (6q25.1)PLEKHG1 (6q25.1) / BMPR2 (2q33.1)
PLEKHG1 (6q25.1) / PLEKHG1 (6q25.1)ARID1B PLEKHG1MTHFD1L PLEKHG1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLEKHG1   20884
Cards
Entrez_Gene (NCBI)PLEKHG1    pleckstrin homology and RhoGEF domain containing G1
AliasesARHGEF41
GeneCards (Weizmann)PLEKHG1
Ensembl hg19 (Hinxton)ENSG00000120278 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120278 [Gene_View]  ENSG00000120278 [Sequence]  chr6:150721099-150843665 [Contig_View]  PLEKHG1 [Vega]
ICGC DataPortalENSG00000120278
TCGA cBioPortalPLEKHG1
AceView (NCBI)PLEKHG1
Genatlas (Paris)PLEKHG1
SOURCE (Princeton)PLEKHG1
Genetics Home Reference (NIH)PLEKHG1
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHG1  -     chr6:150721099-150843665 +  6q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHG1  -     6q25.1   [Description]    (hg19-Feb_2009)
GoldenPathPLEKHG1 - 6q25.1 [CytoView hg19]  PLEKHG1 - 6q25.1 [CytoView hg38]
ImmunoBaseENSG00000120278
Genome Data Viewer NCBIPLEKHG1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB033035 AJ420468 AK056300 AK293288 AK294798
RefSeq transcript (Entrez)NM_001029884 NM_001329798 NM_001329799 NM_001329800 NM_001329801 NM_001329802 NM_001329803 NM_001329804 NM_001329805 NM_001329806
Consensus coding sequences : CCDS (NCBI)PLEKHG1
Gene ExpressionPLEKHG1 [ NCBI-GEO ]   PLEKHG1 [ EBI - ARRAY_EXPRESS ]   PLEKHG1 [ SEEK ]   PLEKHG1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHG1 [ Firebrowse - Broad ]
GenevisibleExpression of PLEKHG1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57480
GTEX Portal (Tissue expression)PLEKHG1
Human Protein AtlasENSG00000120278-PLEKHG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULL1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULL1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULL1
PhosPhoSitePlusQ9ULL1
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    PH-like_dom_sf    PH_domain    PH_PLEKHG1_G2_G3   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)PLEKHG1
SuperfamilyQ9ULL1
AlphaFold pdb e-kbQ9ULL1   
Human Protein Atlas [tissue]ENSG00000120278-PLEKHG1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9ULL1
IntAct (EBI)Q9ULL1
BioGRIDPLEKHG1
STRING (EMBL)PLEKHG1
ZODIACPLEKHG1
Ontologies - Pathways
QuickGOQ9ULL1
Ontology : AmiGOguanyl-nucleotide exchange factor activity  nucleoplasm  regulation of catalytic activity  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  nucleoplasm  regulation of catalytic activity  
NDEx NetworkPLEKHG1
Atlas of Cancer Signalling NetworkPLEKHG1
Wikipedia pathwaysPLEKHG1
Orthology - Evolution
OrthoDB57480
GeneTree (enSembl)ENSG00000120278
Phylogenetic Trees/Animal Genes : TreeFamPLEKHG1
Homologs : HomoloGenePLEKHG1
Homology/Alignments : Family Browser (UCSC)PLEKHG1
Gene fusions - Rearrangements
Fusion : QuiverPLEKHG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHG1
dbVarPLEKHG1
ClinVarPLEKHG1
MonarchPLEKHG1
1000_GenomesPLEKHG1 
Exome Variant ServerPLEKHG1
GNOMAD BrowserENSG00000120278
Varsome BrowserPLEKHG1
ACMGPLEKHG1 variants
VarityQ9ULL1
Genomic Variants (DGV)PLEKHG1 [DGVbeta]
DECIPHERPLEKHG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHG1 
Mutations
ICGC Data PortalPLEKHG1 
TCGA Data PortalPLEKHG1 
Broad Tumor PortalPLEKHG1
OASIS PortalPLEKHG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHG1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLEKHG1
Mutations and Diseases : HGMDPLEKHG1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLEKHG1
DgiDB (Drug Gene Interaction Database)PLEKHG1
DoCM (Curated mutations)PLEKHG1
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHG1
Cancer3DPLEKHG1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPLEKHG1
MedgenPLEKHG1
Genetic Testing Registry PLEKHG1
NextProtQ9ULL1 [Medical]
GENETestsPLEKHG1
Target ValidationPLEKHG1
Huge Navigator PLEKHG1 [HugePedia]
ClinGenPLEKHG1
Clinical trials, drugs, therapy
MyCancerGenomePLEKHG1
Protein Interactions : CTDPLEKHG1
Pharm GKB GenePA134922441
PharosQ9ULL1
Clinical trialPLEKHG1
Miscellaneous
canSAR (ICR)PLEKHG1
HarmonizomePLEKHG1
DataMed IndexPLEKHG1
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLEKHG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:16:26 CEST 2021

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