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PLEKHG2 (pleckstrin homology domain containing, family G (with RhoGef domain) member 2)

Identity

Other namesARHGEF42
CLG
HGNC (Hugo) PLEKHG2
LocusID (NCBI) 64857
Location 19q13.2
Location_base_pair Starts at 39903750 and ends at 39919055 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLEKHG2   29515
Entrez_Gene (NCBI)PLEKHG2  64857  pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Cards
GeneCards (Weizmann)PLEKHG2
Ensembl (Hinxton)ENSG00000090924 [Gene_View]  chr19:39903750-39919055 [Contig_View]  PLEKHG2 [Vega]
AceView (NCBI)PLEKHG2
Genatlas (Paris)PLEKHG2
SOURCE (Stanford)NM_022835
Genomic and cartography
GoldenPath (UCSC)PLEKHG2  -  19q13.2   chr19:39903750-39919055 +  19q13.2   [Description]    (hg19-Feb_2009)
EnsemblPLEKHG2 - 19q13.2 [CytoView]
Mapping of homologs : NCBIPLEKHG2 [Mapview]
OMIM611893   
Gene and transcription
Genbank (Entrez)AK024429 AK026111 AK095957 AK302476 AL832850
RefSeq transcript (SRS)NM_022835
RefSeq transcript (Entrez)NM_022835
RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838496 NW_004078099
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838496 NW_004078099
Consensus coding sequences : CCDS (NCBI)PLEKHG2
Cluster EST : UnigeneHs.631574 [ SRS ] Hs.631574 [ NCBI ]
CGAP (NCI)Hs.631574
Alternative Splicing : Fast-db (Paris)GSHG0014911
Alternative Splicing GalleryENSG00000090924
Gene ExpressionPLEKHG2 [ NCBI-GEO ]   PLEKHG2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H7P9 (SRS) Q9H7P9 (Uniprot)
NextProtQ9H7P9
With graphics : InterProQ9H7P9
Splice isoforms : SwissVarQ9H7P9(Swissvar)
Domaine pattern : Prosite (SRS)DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domaine pattern : Prosite (Expaxy)DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (SRS)DH-domain    PH_like_dom    Pleckstrin_homology   
Domains : Interpro (EBI)DH-domain    PH_like_dom    Pleckstrin_homology   
Related proteins : CluSTrQ9H7P9
Domain families : Pfam (SRS)RhoGEF (PF00621)   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  
DMDM64857
Blocks (Seattle)Q9H7P9
Human Protein AtlasENSG00000090924
HPRD15148
IPIIPI00303373   IPI00645390   IPI00867660   IPI00935618   IPI00917639   IPI00916928   
Protein Interaction databases
DIP (DOE-UCLA)Q9H7P9
IntAct (EBI)Q9H7P9
FunCoupENSG00000090924
REACTOMEPLEKHG2
Protein Interaction Database64857
BioGRIDPLEKHG2
InParanoidQ9H7P9
Interologous Interaction database Q9H7P9
IntegromeDBPLEKHG2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PLEKHG2
SNP (GeneSNP Utah)PLEKHG2
SNP : HGBasePLEKHG2
Genetic variants : HAPMAPPLEKHG2
Somatic Mutations in Cancer : COSMICPLEKHG2 
CONAN: Copy Number AnalysisPLEKHG2 
Mutations and Diseases : HGMDPLEKHG2
OMIM611893   
GENETests611893   
Disease Genetic AssociationPLEKHG2
Huge Navigator PLEKHG2 [HugePedia]  PLEKHG2 [HugeCancerGEM]
Genomic VariantsPLEKHG2  PLEKHG2 [DGVbeta]
ClinVarPLEKHG2
snp3D : Map Gene to Disease64857
General knowledge
Homologs : HomoloGenePLEKHG2
Homology/Alignments : Family Browser (UCSC)PLEKHG2
Phylogenetic Trees/Animal Genes : TreeFamPLEKHG2
Chemical/Protein Interactions : CTD64857
Chemical/Pharm GKB GenePA134893492
Clinical trialPLEKHG2
Cancer Resource (Charite)ENSG00000090924
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  phospholipid binding  cytosol  apoptotic process  small GTPase mediated signal transduction  regulation of Rho protein signal transduction  neurotrophin TRK receptor signaling pathway  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  phospholipid binding  cytosol  apoptotic process  small GTPase mediated signal transduction  regulation of Rho protein signal transduction  neurotrophin TRK receptor signaling pathway  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Other databases
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
PubGenePLEKHG2
iHOPPLEKHG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:58:11 CEST 2013
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