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PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2)

Identity

Alias_namespleckstrin homology domain containing
Alias_symbol (synonym)CLG
FLJ00018
ARHGEF42
Other aliasLDAMD
HGNC (Hugo) PLEKHG2
LocusID (NCBI) 64857
Atlas_Id 40101
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39413110 and ends at 39428415 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLEKHG2 (19q13.2) / PLEKHG2 (19q13.2)TEX22 (14q32.33) / PLEKHG2 (19q13.2)TLE3 (15q23) / PLEKHG2 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEKHG2   29515
Cards
Entrez_Gene (NCBI)PLEKHG2  64857  pleckstrin homology and RhoGEF domain containing G2
AliasesARHGEF42; CLG; LDAMD
GeneCards (Weizmann)PLEKHG2
Ensembl hg19 (Hinxton)ENSG00000090924 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090924 [Gene_View]  chr19:39413110-39428415 [Contig_View]  PLEKHG2 [Vega]
ICGC DataPortalENSG00000090924
TCGA cBioPortalPLEKHG2
AceView (NCBI)PLEKHG2
Genatlas (Paris)PLEKHG2
WikiGenes64857
SOURCE (Princeton)PLEKHG2
Genetics Home Reference (NIH)PLEKHG2
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHG2  -     chr19:39413110-39428415 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHG2  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblPLEKHG2 - 19q13.2 [CytoView hg19]  PLEKHG2 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIPLEKHG2 [Mapview hg19]  PLEKHG2 [Mapview hg38]
OMIM611893   616763   
Gene and transcription
Genbank (Entrez)AK024429 AK026111 AK095957 AK302476 AL832850
RefSeq transcript (Entrez)NM_022835
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEKHG2
Cluster EST : UnigeneHs.631574 [ NCBI ]
CGAP (NCI)Hs.631574
Alternative Splicing GalleryENSG00000090924
Gene ExpressionPLEKHG2 [ NCBI-GEO ]   PLEKHG2 [ EBI - ARRAY_EXPRESS ]   PLEKHG2 [ SEEK ]   PLEKHG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64857
GTEX Portal (Tissue expression)PLEKHG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H7P9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H7P9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H7P9
Splice isoforms : SwissVarQ9H7P9
PhosPhoSitePlusQ9H7P9
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00169    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)PLEKHG2
DMDM Disease mutations64857
Blocks (Seattle)PLEKHG2
SuperfamilyQ9H7P9
Human Protein AtlasENSG00000090924
Peptide AtlasQ9H7P9
HPRD15148
IPIIPI00303373   IPI00645390   IPI00867660   IPI00935618   IPI00917639   IPI00916928   
Protein Interaction databases
DIP (DOE-UCLA)Q9H7P9
IntAct (EBI)Q9H7P9
FunCoupENSG00000090924
BioGRIDPLEKHG2
STRING (EMBL)PLEKHG2
ZODIACPLEKHG2
Ontologies - Pathways
QuickGOQ9H7P9
Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytosol  regulation of Rho protein signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytosol  regulation of Rho protein signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkPLEKHG2
Atlas of Cancer Signalling NetworkPLEKHG2
Wikipedia pathwaysPLEKHG2
Orthology - Evolution
OrthoDB64857
GeneTree (enSembl)ENSG00000090924
Phylogenetic Trees/Animal Genes : TreeFamPLEKHG2
HOVERGENQ9H7P9
HOGENOMQ9H7P9
Homologs : HomoloGenePLEKHG2
Homology/Alignments : Family Browser (UCSC)PLEKHG2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHG2
dbVarPLEKHG2
ClinVarPLEKHG2
1000_GenomesPLEKHG2 
Exome Variant ServerPLEKHG2
ExAC (Exome Aggregation Consortium)PLEKHG2 (select the gene name)
Genetic variants : HAPMAP64857
Genomic Variants (DGV)PLEKHG2 [DGVbeta]
DECIPHERPLEKHG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHG2 
Mutations
ICGC Data PortalPLEKHG2 
TCGA Data PortalPLEKHG2 
Broad Tumor PortalPLEKHG2
OASIS PortalPLEKHG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEKHG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHG2
DgiDB (Drug Gene Interaction Database)PLEKHG2
DoCM (Curated mutations)PLEKHG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHG2 (select a term)
intoGenPLEKHG2
Cancer3DPLEKHG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611893    616763   
Orphanet
MedgenPLEKHG2
Genetic Testing Registry PLEKHG2
NextProtQ9H7P9 [Medical]
TSGene64857
GENETestsPLEKHG2
Huge Navigator PLEKHG2 [HugePedia]
snp3D : Map Gene to Disease64857
BioCentury BCIQPLEKHG2
ClinGenPLEKHG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64857
Chemical/Pharm GKB GenePA134893492
Clinical trialPLEKHG2
Miscellaneous
canSAR (ICR)PLEKHG2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHG2
EVEXPLEKHG2
GoPubMedPLEKHG2
iHOPPLEKHG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:31:37 CEST 2017

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