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PLEKHG4B (pleckstrin homology and RhoGEF domain containing G4B)

Identity

Alias_namespleckstrin homology domain containing
Alias_symbol (synonym)KIAA1909
Other alias-
HGNC (Hugo) PLEKHG4B
LocusID (NCBI) 153478
Atlas_Id 43332
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 140373 and ends at 190087 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NRXN1 (2p16.3) / PLEKHG4B (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PLEKHG4B   29399
Cards
Entrez_Gene (NCBI)PLEKHG4B  153478  pleckstrin homology and RhoGEF domain containing G4B
Aliases
GeneCards (Weizmann)PLEKHG4B
Ensembl hg19 (Hinxton)ENSG00000153404 [Gene_View]  chr5:140373-190087 [Contig_View]  PLEKHG4B [Vega]
Ensembl hg38 (Hinxton)ENSG00000153404 [Gene_View]  chr5:140373-190087 [Contig_View]  PLEKHG4B [Vega]
ICGC DataPortalENSG00000153404
TCGA cBioPortalPLEKHG4B
AceView (NCBI)PLEKHG4B
Genatlas (Paris)PLEKHG4B
WikiGenes153478
SOURCE (Princeton)PLEKHG4B
Genetics Home Reference (NIH)PLEKHG4B
Genomic and cartography
GoldenPath hg19 (UCSC)PLEKHG4B  -     chr5:140373-190087 +  5p15.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLEKHG4B  -     5p15.33   [Description]    (hg38-Dec_2013)
EnsemblPLEKHG4B - 5p15.33 [CytoView hg19]  PLEKHG4B - 5p15.33 [CytoView hg38]
Mapping of homologs : NCBIPLEKHG4B [Mapview hg19]  PLEKHG4B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB067496 AI561188 AK075513 AK125163 AK309784
RefSeq transcript (Entrez)NM_052909
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_006576 NW_004929321
Consensus coding sequences : CCDS (NCBI)PLEKHG4B
Cluster EST : UnigeneHs.535800 [ NCBI ]
CGAP (NCI)Hs.535800
Alternative Splicing GalleryENSG00000153404
Gene ExpressionPLEKHG4B [ NCBI-GEO ]   PLEKHG4B [ EBI - ARRAY_EXPRESS ]   PLEKHG4B [ SEEK ]   PLEKHG4B [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHG4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)153478
GTEX Portal (Tissue expression)PLEKHG4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PX9
Splice isoforms : SwissVarQ96PX9
PhosPhoSitePlusQ96PX9
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)PLEKHG4B
DMDM Disease mutations153478
Blocks (Seattle)PLEKHG4B
SuperfamilyQ96PX9
Human Protein AtlasENSG00000153404
Peptide AtlasQ96PX9
HPRD13900
IPIIPI00885174   IPI00873930   
Protein Interaction databases
DIP (DOE-UCLA)Q96PX9
IntAct (EBI)Q96PX9
FunCoupENSG00000153404
BioGRIDPLEKHG4B
STRING (EMBL)PLEKHG4B
ZODIACPLEKHG4B
Ontologies - Pathways
QuickGOQ96PX9
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
NDEx NetworkPLEKHG4B
Atlas of Cancer Signalling NetworkPLEKHG4B
Wikipedia pathwaysPLEKHG4B
Orthology - Evolution
OrthoDB153478
GeneTree (enSembl)ENSG00000153404
Phylogenetic Trees/Animal Genes : TreeFamPLEKHG4B
HOVERGENQ96PX9
HOGENOMQ96PX9
Homologs : HomoloGenePLEKHG4B
Homology/Alignments : Family Browser (UCSC)PLEKHG4B
Gene fusions - Rearrangements
Fusion : MitelmanNRXN1/PLEKHG4B [2p16.3/5p15.33]  [t(2;5)(p16;p15)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHG4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHG4B
dbVarPLEKHG4B
ClinVarPLEKHG4B
1000_GenomesPLEKHG4B 
Exome Variant ServerPLEKHG4B
ExAC (Exome Aggregation Consortium)PLEKHG4B (select the gene name)
Genetic variants : HAPMAP153478
Genomic Variants (DGV)PLEKHG4B [DGVbeta]
DECIPHER (Syndromes)5:140373-190087  ENSG00000153404
CONAN: Copy Number AnalysisPLEKHG4B 
Mutations
ICGC Data PortalPLEKHG4B 
TCGA Data PortalPLEKHG4B 
Broad Tumor PortalPLEKHG4B
OASIS PortalPLEKHG4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHG4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEKHG4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHG4B
DgiDB (Drug Gene Interaction Database)PLEKHG4B
DoCM (Curated mutations)PLEKHG4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHG4B (select a term)
intoGenPLEKHG4B
Cancer3DPLEKHG4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPLEKHG4B
Genetic Testing Registry PLEKHG4B
NextProtQ96PX9 [Medical]
TSGene153478
GENETestsPLEKHG4B
Huge Navigator PLEKHG4B [HugePedia]
snp3D : Map Gene to Disease153478
BioCentury BCIQPLEKHG4B
ClinGenPLEKHG4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD153478
Chemical/Pharm GKB GenePA162399667
Clinical trialPLEKHG4B
Miscellaneous
canSAR (ICR)PLEKHG4B (select the gene name)
Probes
Litterature
PubMed2 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHG4B
EVEXPLEKHG4B
GoPubMedPLEKHG4B
iHOPPLEKHG4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:21:48 CET 2017

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