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PLEKHG7 (pleckstrin homology and RhoGEF domain containing G7)

Identity

Alias_namespleckstrin homology domain containing, family G (with RhoGef domain) member 7
Alias_symbol (synonym)FLJ46688
Other alias-
HGNC (Hugo) PLEKHG7
LocusID (NCBI) 440107
Atlas_Id 71982
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 92736489 and ends at 92772092 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEKHG7   33829
Cards
Entrez_Gene (NCBI)PLEKHG7  440107  pleckstrin homology and RhoGEF domain containing G7
Aliases
GeneCards (Weizmann)PLEKHG7
Ensembl hg19 (Hinxton)ENSG00000187510 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187510 [Gene_View]  chr12:92736489-92772092 [Contig_View]  PLEKHG7 [Vega]
ICGC DataPortalENSG00000187510
TCGA cBioPortalPLEKHG7
AceView (NCBI)PLEKHG7
Genatlas (Paris)PLEKHG7
WikiGenes440107
SOURCE (Princeton)PLEKHG7
Genetics Home Reference (NIH)PLEKHG7
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHG7  -     chr12:92736489-92772092 +  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHG7  -     12q22   [Description]    (hg19-Feb_2009)
EnsemblPLEKHG7 - 12q22 [CytoView hg19]  PLEKHG7 - 12q22 [CytoView hg38]
Mapping of homologs : NCBIPLEKHG7 [Mapview hg19]  PLEKHG7 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK128530 BC137086
RefSeq transcript (Entrez)NM_001004330
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEKHG7
Cluster EST : UnigeneHs.591013 [ NCBI ]
CGAP (NCI)Hs.591013
Alternative Splicing GalleryENSG00000187510
Gene ExpressionPLEKHG7 [ NCBI-GEO ]   PLEKHG7 [ EBI - ARRAY_EXPRESS ]   PLEKHG7 [ SEEK ]   PLEKHG7 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHG7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)440107
GTEX Portal (Tissue expression)PLEKHG7
Human Protein AtlasENSG00000187510-PLEKHG7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZR37   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZR37  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZR37
Splice isoforms : SwissVarQ6ZR37
PhosPhoSitePlusQ6ZR37
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)PLEKHG7
DMDM Disease mutations440107
Blocks (Seattle)PLEKHG7
SuperfamilyQ6ZR37
Human Protein Atlas [tissue]ENSG00000187510-PLEKHG7 [tissue]
Peptide AtlasQ6ZR37
HPRD17004
IPIIPI00456962   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZR37
IntAct (EBI)Q6ZR37
FunCoupENSG00000187510
BioGRIDPLEKHG7
STRING (EMBL)PLEKHG7
ZODIACPLEKHG7
Ontologies - Pathways
QuickGOQ6ZR37
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
NDEx NetworkPLEKHG7
Atlas of Cancer Signalling NetworkPLEKHG7
Wikipedia pathwaysPLEKHG7
Orthology - Evolution
OrthoDB440107
GeneTree (enSembl)ENSG00000187510
Phylogenetic Trees/Animal Genes : TreeFamPLEKHG7
HOVERGENQ6ZR37
HOGENOMQ6ZR37
Homologs : HomoloGenePLEKHG7
Homology/Alignments : Family Browser (UCSC)PLEKHG7
Gene fusions - Rearrangements
Fusion: Tumor Portal PLEKHG7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHG7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHG7
dbVarPLEKHG7
ClinVarPLEKHG7
1000_GenomesPLEKHG7 
Exome Variant ServerPLEKHG7
ExAC (Exome Aggregation Consortium)ENSG00000187510
GNOMAD BrowserENSG00000187510
Genetic variants : HAPMAP440107
Genomic Variants (DGV)PLEKHG7 [DGVbeta]
DECIPHERPLEKHG7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHG7 
Mutations
ICGC Data PortalPLEKHG7 
TCGA Data PortalPLEKHG7 
Broad Tumor PortalPLEKHG7
OASIS PortalPLEKHG7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHG7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEKHG7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHG7
DgiDB (Drug Gene Interaction Database)PLEKHG7
DoCM (Curated mutations)PLEKHG7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHG7 (select a term)
intoGenPLEKHG7
Cancer3DPLEKHG7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPLEKHG7
Genetic Testing Registry PLEKHG7
NextProtQ6ZR37 [Medical]
TSGene440107
GENETestsPLEKHG7
Target ValidationPLEKHG7
Huge Navigator PLEKHG7 [HugePedia]
snp3D : Map Gene to Disease440107
BioCentury BCIQPLEKHG7
ClinGenPLEKHG7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD440107
Chemical/Pharm GKB GenePA162399708
Clinical trialPLEKHG7
Miscellaneous
canSAR (ICR)PLEKHG7 (select the gene name)
Probes
Litterature
PubMed3 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHG7
EVEXPLEKHG7
GoPubMedPLEKHG7
iHOPPLEKHG7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:22:48 CET 2017

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