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PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3)

Identity

Alias_namespleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Alias_symbol (synonym)FLJ21019
Other alias-
HGNC (Hugo) PLEKHH3
LocusID (NCBI) 79990
Atlas_Id 71984
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42667915 and ends at 42677030 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BC040576 () / PLEKHH3 (17q21.2)CDAN1 (15q15.2) / PLEKHH3 (17q21.2)PLEKHH3 (17q21.2) / PTBP1 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEKHH3   26105
Cards
Entrez_Gene (NCBI)PLEKHH3  79990  pleckstrin homology, MyTH4 and FERM domain containing H3
Aliases
GeneCards (Weizmann)PLEKHH3
Ensembl hg19 (Hinxton)ENSG00000068137 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068137 [Gene_View]  chr17:42667915-42677030 [Contig_View]  PLEKHH3 [Vega]
ICGC DataPortalENSG00000068137
TCGA cBioPortalPLEKHH3
AceView (NCBI)PLEKHH3
Genatlas (Paris)PLEKHH3
WikiGenes79990
SOURCE (Princeton)PLEKHH3
Genetics Home Reference (NIH)PLEKHH3
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHH3  -     chr17:42667915-42677030 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHH3  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblPLEKHH3 - 17q21.2 [CytoView hg19]  PLEKHH3 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIPLEKHH3 [Mapview hg19]  PLEKHH3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB208939 AK024672 AK096767 AL137584 BC016062
RefSeq transcript (Entrez)NM_024927
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLEKHH3
Cluster EST : UnigeneHs.632251 [ NCBI ]
CGAP (NCI)Hs.632251
Alternative Splicing GalleryENSG00000068137
Gene ExpressionPLEKHH3 [ NCBI-GEO ]   PLEKHH3 [ EBI - ARRAY_EXPRESS ]   PLEKHH3 [ SEEK ]   PLEKHH3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHH3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79990
GTEX Portal (Tissue expression)PLEKHH3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z736   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z736  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z736
Splice isoforms : SwissVarQ7Z736
PhosPhoSitePlusQ7Z736
Domaine pattern : Prosite (Expaxy)FERM_3 (PS50057)    MYTH4 (PS51016)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Band_41_domain    FERM_central    FERM_domain    MyTH4_dom    PH_dom-like    PH_domain    RA_dom   
Domain families : Pfam (Sanger)FERM_M (PF00373)    MyTH4 (PF00784)    RA (PF00788)   
Domain families : Pfam (NCBI)pfam00373    pfam00784    pfam00788   
Domain families : Smart (EMBL)B41 (SM00295)  MyTH4 (SM00139)  PH (SM00233)  
Conserved Domain (NCBI)PLEKHH3
DMDM Disease mutations79990
Blocks (Seattle)PLEKHH3
SuperfamilyQ7Z736
Human Protein AtlasENSG00000068137
Peptide AtlasQ7Z736
HPRD13381
IPIIPI00152977   IPI00874273   IPI00556551   IPI00873064   IPI01026025   IPI00953688   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z736
IntAct (EBI)Q7Z736
FunCoupENSG00000068137
BioGRIDPLEKHH3
STRING (EMBL)PLEKHH3
ZODIACPLEKHH3
Ontologies - Pathways
QuickGOQ7Z736
Ontology : AmiGOextracellular space  cytoskeleton  signal transduction  
Ontology : EGO-EBIextracellular space  cytoskeleton  signal transduction  
NDEx NetworkPLEKHH3
Atlas of Cancer Signalling NetworkPLEKHH3
Wikipedia pathwaysPLEKHH3
Orthology - Evolution
OrthoDB79990
GeneTree (enSembl)ENSG00000068137
Phylogenetic Trees/Animal Genes : TreeFamPLEKHH3
HOVERGENQ7Z736
HOGENOMQ7Z736
Homologs : HomoloGenePLEKHH3
Homology/Alignments : Family Browser (UCSC)PLEKHH3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHH3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHH3
dbVarPLEKHH3
ClinVarPLEKHH3
1000_GenomesPLEKHH3 
Exome Variant ServerPLEKHH3
ExAC (Exome Aggregation Consortium)PLEKHH3 (select the gene name)
Genetic variants : HAPMAP79990
Genomic Variants (DGV)PLEKHH3 [DGVbeta]
DECIPHERPLEKHH3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHH3 
Mutations
ICGC Data PortalPLEKHH3 
TCGA Data PortalPLEKHH3 
Broad Tumor PortalPLEKHH3
OASIS PortalPLEKHH3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHH3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEKHH3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHH3
DgiDB (Drug Gene Interaction Database)PLEKHH3
DoCM (Curated mutations)PLEKHH3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHH3 (select a term)
intoGenPLEKHH3
Cancer3DPLEKHH3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPLEKHH3
Genetic Testing Registry PLEKHH3
NextProtQ7Z736 [Medical]
TSGene79990
GENETestsPLEKHH3
Target ValidationPLEKHH3
Huge Navigator PLEKHH3 [HugePedia]
snp3D : Map Gene to Disease79990
BioCentury BCIQPLEKHH3
ClinGenPLEKHH3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79990
Chemical/Pharm GKB GenePA143485577
Clinical trialPLEKHH3
Miscellaneous
canSAR (ICR)PLEKHH3 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHH3
EVEXPLEKHH3
GoPubMedPLEKHH3
iHOPPLEKHH3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:36:36 CEST 2017

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