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PLEKHM3 (pleckstrin homology domain containing M3)

Identity

Alias (NCBI)DAPR
PLEKHM1L
HGNC (Hugo) PLEKHM3
HGNC Alias symbDAPR
HGNC Alias namedifferentiation associated protein
HGNC Previous namePLEKHM1L
HGNC Previous namepleckstrin homology domain containing, family M, member 1-like
 pleckstrin homology domain containing, family M, member 3
LocusID (NCBI) 389072
Atlas_Id 71988
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 207821288 and ends at 208025527 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IQCA1 (2q37.2) / PLEKHM3 (2q33.3)METTL21A (2q33.3) / PLEKHM3 (2q33.3)PLEKHM3 (2q33.3) / KIF5A (12q13.3)
PLEKHM3 (2q33.3) / RNF24 (20p13)SEC23B (20p11.23) / PLEKHM3 (2q33.3)STK32B (4p16.2) / PLEKHM3 (2q33.3)
METTL21A PLEKHM3SEC23B PLEKHM3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLEKHM3   34006
Cards
Entrez_Gene (NCBI)PLEKHM3    pleckstrin homology domain containing M3
AliasesDAPR; PLEKHM1L
GeneCards (Weizmann)PLEKHM3
Ensembl hg19 (Hinxton)ENSG00000178385 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178385 [Gene_View]  ENSG00000178385 [Sequence]  chr2:207821288-208025527 [Contig_View]  PLEKHM3 [Vega]
ICGC DataPortalENSG00000178385
TCGA cBioPortalPLEKHM3
AceView (NCBI)PLEKHM3
Genatlas (Paris)PLEKHM3
SOURCE (Princeton)PLEKHM3
Genetics Home Reference (NIH)PLEKHM3
Genomic and cartography
GoldenPath hg38 (UCSC)PLEKHM3  -     chr2:207821288-208025527 -  2q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLEKHM3  -     2q33.3   [Description]    (hg19-Feb_2009)
GoldenPathPLEKHM3 - 2q33.3 [CytoView hg19]  PLEKHM3 - 2q33.3 [CytoView hg38]
ImmunoBaseENSG00000178385
Genome Data Viewer NCBIPLEKHM3 [Mapview hg19]  
OMIM619186   
Gene and transcription
Genbank (Entrez)AF462444 AK057612 AK123204 BC020812 BC042862
RefSeq transcript (Entrez)NM_001080475
Consensus coding sequences : CCDS (NCBI)PLEKHM3
Gene ExpressionPLEKHM3 [ NCBI-GEO ]   PLEKHM3 [ EBI - ARRAY_EXPRESS ]   PLEKHM3 [ SEEK ]   PLEKHM3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHM3 [ Firebrowse - Broad ]
GenevisibleExpression of PLEKHM3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389072
GTEX Portal (Tissue expression)PLEKHM3
Human Protein AtlasENSG00000178385-PLEKHM3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZWE6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZWE6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZWE6
PhosPhoSitePlusQ6ZWE6
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    PLEKHM3_PH_1    Zf-RING_9   
Domain families : Pfam (Sanger)PH (PF00169)    zf-RING_9 (PF13901)   
Domain families : Pfam (NCBI)pfam00169    pfam13901   
Domain families : Smart (EMBL)DUF4206 (SM01175)  PH (SM00233)  
Conserved Domain (NCBI)PLEKHM3
SuperfamilyQ6ZWE6
AlphaFold pdb e-kbQ6ZWE6   
Human Protein Atlas [tissue]ENSG00000178385-PLEKHM3 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q6ZWE6
IntAct (EBI)Q6ZWE6
BioGRIDPLEKHM3
STRING (EMBL)PLEKHM3
ZODIACPLEKHM3
Ontologies - Pathways
QuickGOQ6ZWE6
Ontology : AmiGOcytoplasm  Golgi apparatus  plasma membrane  myoblast differentiation  metal ion binding  
Ontology : EGO-EBIcytoplasm  Golgi apparatus  plasma membrane  myoblast differentiation  metal ion binding  
NDEx NetworkPLEKHM3
Atlas of Cancer Signalling NetworkPLEKHM3
Wikipedia pathwaysPLEKHM3
Orthology - Evolution
OrthoDB389072
GeneTree (enSembl)ENSG00000178385
Phylogenetic Trees/Animal Genes : TreeFamPLEKHM3
Homologs : HomoloGenePLEKHM3
Homology/Alignments : Family Browser (UCSC)PLEKHM3
Gene fusions - Rearrangements
Fusion : QuiverPLEKHM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHM3
dbVarPLEKHM3
ClinVarPLEKHM3
MonarchPLEKHM3
1000_GenomesPLEKHM3 
Exome Variant ServerPLEKHM3
GNOMAD BrowserENSG00000178385
Varsome BrowserPLEKHM3
ACMGPLEKHM3 variants
VarityQ6ZWE6
Genomic Variants (DGV)PLEKHM3 [DGVbeta]
DECIPHERPLEKHM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLEKHM3 
Mutations
ICGC Data PortalPLEKHM3 
TCGA Data PortalPLEKHM3 
Broad Tumor PortalPLEKHM3
OASIS PortalPLEKHM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHM3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLEKHM3
Mutations and Diseases : HGMDPLEKHM3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLEKHM3
DgiDB (Drug Gene Interaction Database)PLEKHM3
DoCM (Curated mutations)PLEKHM3
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHM3
Cancer3DPLEKHM3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619186   
Orphanet
DisGeNETPLEKHM3
MedgenPLEKHM3
Genetic Testing Registry PLEKHM3
NextProtQ6ZWE6 [Medical]
GENETestsPLEKHM3
Target ValidationPLEKHM3
Huge Navigator PLEKHM3 [HugePedia]
ClinGenPLEKHM3
Clinical trials, drugs, therapy
MyCancerGenomePLEKHM3
Protein Interactions : CTDPLEKHM3
Pharm GKB GenePA162399738
PharosQ6ZWE6
Clinical trialPLEKHM3
Miscellaneous
canSAR (ICR)PLEKHM3
HarmonizomePLEKHM3
DataMed IndexPLEKHM3
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLEKHM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:16:28 CEST 2021

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