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PLEKHM3 (pleckstrin homology domain containing, family M, member 3)

Identity

Alias_namesPLEKHM1L
pleckstrin homology domain containing, family M, member 1-like
pleckstrin homology domain containing, family M, member 3
Alias_symbol (synonym)DAPR
Other alias
HGNC (Hugo) PLEKHM3
LocusID (NCBI) 389072
Atlas_Id 71988
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 208686012 and ends at 208890284 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IQCA1 (2q37.2) / PLEKHM3 (2q33.3)METTL21A (2q33.3) / PLEKHM3 (2q33.3)PLEKHM3 (2q33.3) / KIF5A (12q13.3)
PLEKHM3 (2q33.3) / RNF24 (20p13)SEC23B (20p11.23) / PLEKHM3 (2q33.3)STK32B (4p16.2) / PLEKHM3 (2q33.3)
METTL21A PLEKHM3SEC23B PLEKHM3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLEKHM3   34006
Cards
Entrez_Gene (NCBI)PLEKHM3  389072  pleckstrin homology domain containing, family M, member 3
AliasesDAPR; PLEKHM1L
GeneCards (Weizmann)PLEKHM3
Ensembl hg19 (Hinxton)ENSG00000178385 [Gene_View]  chr2:208686012-208890284 [Contig_View]  PLEKHM3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000178385 [Gene_View]  chr2:208686012-208890284 [Contig_View]  PLEKHM3 [Vega]
ICGC DataPortalENSG00000178385
TCGA cBioPortalPLEKHM3
AceView (NCBI)PLEKHM3
Genatlas (Paris)PLEKHM3
WikiGenes389072
SOURCE (Princeton)PLEKHM3
Genetics Home Reference (NIH)PLEKHM3
Genomic and cartography
GoldenPath hg19 (UCSC)PLEKHM3  -     chr2:208686012-208890284 -  2q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLEKHM3  -     2q33.3   [Description]    (hg38-Dec_2013)
EnsemblPLEKHM3 - 2q33.3 [CytoView hg19]  PLEKHM3 - 2q33.3 [CytoView hg38]
Mapping of homologs : NCBIPLEKHM3 [Mapview hg19]  PLEKHM3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF462444 AK057612 AK123204 BC020812 BC042862
RefSeq transcript (Entrez)NM_001080475
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)PLEKHM3
Cluster EST : UnigeneHs.709906 [ NCBI ]
CGAP (NCI)Hs.709906
Alternative Splicing GalleryENSG00000178385
Gene ExpressionPLEKHM3 [ NCBI-GEO ]   PLEKHM3 [ EBI - ARRAY_EXPRESS ]   PLEKHM3 [ SEEK ]   PLEKHM3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLEKHM3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389072
GTEX Portal (Tissue expression)PLEKHM3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZWE6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZWE6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZWE6
Splice isoforms : SwissVarQ6ZWE6
PhosPhoSitePlusQ6ZWE6
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DUF4206    PE/DAG-bd    PH_domain    PH_like_dom   
Domain families : Pfam (Sanger)DUF4206 (PF13901)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam13901    pfam00169   
Domain families : Smart (EMBL)C1 (SM00109)  PH (SM00233)  
Conserved Domain (NCBI)PLEKHM3
DMDM Disease mutations389072
Blocks (Seattle)PLEKHM3
SuperfamilyQ6ZWE6
Human Protein AtlasENSG00000178385
Peptide AtlasQ6ZWE6
IPIIPI00784284   IPI00746381   IPI00886950   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZWE6
IntAct (EBI)Q6ZWE6
FunCoupENSG00000178385
BioGRIDPLEKHM3
STRING (EMBL)PLEKHM3
ZODIACPLEKHM3
Ontologies - Pathways
QuickGOQ6ZWE6
Ontology : AmiGOintracellular  intracellular signal transduction  metal ion binding  
Ontology : EGO-EBIintracellular  intracellular signal transduction  metal ion binding  
NDEx NetworkPLEKHM3
Atlas of Cancer Signalling NetworkPLEKHM3
Wikipedia pathwaysPLEKHM3
Orthology - Evolution
OrthoDB389072
GeneTree (enSembl)ENSG00000178385
Phylogenetic Trees/Animal Genes : TreeFamPLEKHM3
HOVERGENQ6ZWE6
HOGENOMQ6ZWE6
Homologs : HomoloGenePLEKHM3
Homology/Alignments : Family Browser (UCSC)PLEKHM3
Gene fusions - Rearrangements
Fusion: TCGAMETTL21A PLEKHM3
Fusion: TCGASEC23B PLEKHM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLEKHM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLEKHM3
dbVarPLEKHM3
ClinVarPLEKHM3
1000_GenomesPLEKHM3 
Exome Variant ServerPLEKHM3
ExAC (Exome Aggregation Consortium)PLEKHM3 (select the gene name)
Genetic variants : HAPMAP389072
Genomic Variants (DGV)PLEKHM3 [DGVbeta]
DECIPHER (Syndromes)2:208686012-208890284  ENSG00000178385
CONAN: Copy Number AnalysisPLEKHM3 
Mutations
ICGC Data PortalPLEKHM3 
TCGA Data PortalPLEKHM3 
Broad Tumor PortalPLEKHM3
OASIS PortalPLEKHM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLEKHM3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLEKHM3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLEKHM3
DgiDB (Drug Gene Interaction Database)PLEKHM3
DoCM (Curated mutations)PLEKHM3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLEKHM3 (select a term)
intoGenPLEKHM3
Cancer3DPLEKHM3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPLEKHM3
Genetic Testing Registry PLEKHM3
NextProtQ6ZWE6 [Medical]
TSGene389072
GENETestsPLEKHM3
Huge Navigator PLEKHM3 [HugePedia]
snp3D : Map Gene to Disease389072
BioCentury BCIQPLEKHM3
ClinGenPLEKHM3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD389072
Chemical/Pharm GKB GenePA162399738
Clinical trialPLEKHM3
Miscellaneous
canSAR (ICR)PLEKHM3 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLEKHM3
EVEXPLEKHM3
GoPubMedPLEKHM3
iHOPPLEKHM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:38:54 CET 2017

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