PLG (plasminogen)

2003-02-01  

Identity

HGNC
LOCATION
6q26
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5340
MIM: 173350
HGNC: 9071
Ensembl: ENSG00000122194

Variants:

dbSNP: 5340
ClinVar: 5340
TCGA: ENSG00000122194
COSMIC: PLG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122194ENST00000308192P00747
ENSG00000122194ENST00000366924Q5TEH5
ENSG00000122194ENST00000418964A6PVI2

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Dissolution of Fibrin ClotREACTOMER-HSA-75205
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153338382004Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.151
205536062010Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.106
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
189811802008Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.79
167905222006Trigger for group A streptococcal M1T1 invasive disease.71
172725022007Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.53
185666722008Plasminogen alleles influence susceptibility to invasive aspergillosis.53
185666722008Plasminogen alleles influence susceptibility to invasive aspergillosis.53
176067602007Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.51
228321922012The X-ray crystal structure of full-length human plasminogen.48

Citation

Dessen P

PLG (plasminogen)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41746/plg