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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

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PLG (plasminogen)

Identity

Other names-
HGNC (Hugo) PLG
LocusID (NCBI) 5340
Location 6q26
Location_base_pair Starts at 161123225 and ends at 161175085 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLG   9071
Cards
Entrez_Gene (NCBI)PLG  5340  plasminogen
GeneCards (Weizmann)PLG
Ensembl hg19 (Hinxton)ENSG00000122194 [Gene_View]  chr6:161123225-161175085 [Contig_View]  PLG [Vega]
Ensembl hg38 (Hinxton)ENSG00000122194 [Gene_View]  chr6:161123225-161175085 [Contig_View]  PLG [Vega]
ICGC DataPortalENSG00000122194
cBioPortalPLG
AceView (NCBI)PLG
Genatlas (Paris)PLG
WikiGenes5340
SOURCE (Princeton)PLG
Genomic and cartography
GoldenPath hg19 (UCSC)PLG  -     chr6:161123225-161175085 +  6q26   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLG  -     6q26   [Description]    (hg38-Dec_2013)
EnsemblPLG - 6q26 [CytoView hg19]  PLG - 6q26 [CytoView hg38]
Mapping of homologs : NCBIPLG [Mapview hg19]  PLG [Mapview hg38]
OMIM173350   217090   
Gene and transcription
Genbank (Entrez)AK298338 AK308036 AK312966 BC060513 BU073846
RefSeq transcript (Entrez)NM_000301 NM_001168338
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_016200 NT_025741 NW_001838992 NW_004929328
Consensus coding sequences : CCDS (NCBI)PLG
Cluster EST : UnigeneHs.143436 [ NCBI ]
CGAP (NCI)Hs.143436
Alternative Splicing : Fast-db (Paris)GSHG0026185
Alternative Splicing GalleryENSG00000122194
Gene ExpressionPLG [ NCBI-GEO ]     PLG [ SEEK ]   PLG [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00747 (Uniprot)
NextProtP00747  [Medical]
With graphics : InterProP00747
Splice isoforms : SwissVarP00747 (Swissvar)
Catalytic activity : Enzyme3.4.21.7 [ Enzyme-Expasy ]   3.4.21.73.4.21.7 [ IntEnz-EBI ]   3.4.21.7 [ BRENDA ]   3.4.21.7 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    PAN (PS50948)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Kringle    Kringle-like    Kringle_CS    PAN-1_domain    Pan_app    Pept_S1A_plasmin    Peptidase_S1    Peptidase_S1_AS    Peptidase_S1A    Trypsin-like_Pept_dom   
Related proteins : CluSTrP00747
Domain families : Pfam (Sanger)Kringle (PF00051)    PAN_1 (PF00024)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00051    pfam00024    pfam00089   
Domain families : Smart (EMBL)KR (SM00130)  PAN_AP (SM00473)  Tryp_SPc (SM00020)  
DMDM Disease mutations5340
Blocks (Seattle)P00747
PDB (SRS)1B2I    1BML    1BUI    1CEA    1CEB    1DDJ    1HPJ    1HPK    1I5K    1KI0    1KRN    1L4D    1L4Z    1PK4    1PKR    1PMK    1QRZ    1RJX    2DOH    2DOI    2KNF    2L0S    2PK4    3UIR    4A5T    4DCB    4DUR    4DUU    5HPG   
PDB (PDBSum)1B2I    1BML    1BUI    1CEA    1CEB    1DDJ    1HPJ    1HPK    1I5K    1KI0    1KRN    1L4D    1L4Z    1PK4    1PKR    1PMK    1QRZ    1RJX    2DOH    2DOI    2KNF    2L0S    2PK4    3UIR    4A5T    4DCB    4DUR    4DUU    5HPG   
PDB (IMB)1B2I    1BML    1BUI    1CEA    1CEB    1DDJ    1HPJ    1HPK    1I5K    1KI0    1KRN    1L4D    1L4Z    1PK4    1PKR    1PMK    1QRZ    1RJX    2DOH    2DOI    2KNF    2L0S    2PK4    3UIR    4A5T    4DCB    4DUR    4DUU    5HPG   
PDB (RSDB)1B2I    1BML    1BUI    1CEA    1CEB    1DDJ    1HPJ    1HPK    1I5K    1KI0    1KRN    1L4D    1L4Z    1PK4    1PKR    1PMK    1QRZ    1RJX    2DOH    2DOI    2KNF    2L0S    2PK4    3UIR    4A5T    4DCB    4DUR    4DUU    5HPG   
Human Protein AtlasENSG00000122194
Peptide AtlasP00747
HPRD01417
IPIIPI00019580   IPI01010789   IPI00025327   IPI00855913   
Protein Interaction databases
DIP (DOE-UCLA)P00747
IntAct (EBI)P00747
FunCoupENSG00000122194
BioGRIDPLG
IntegromeDBPLG
STRING (EMBL)PLG
Ontologies - Pathways
QuickGOP00747
Ontology : AmiGOplatelet degranulation  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  plasma membrane  blood coagulation  blood coagulation  serine-type peptidase activity  negative regulation of cell proliferation  cell surface  negative regulation of cell-substrate adhesion  protein domain specific binding  extracellular matrix disassembly  extracellular matrix disassembly  platelet activation  extracellular matrix organization  platelet alpha granule lumen  extrinsic component of external side of plasma membrane  apolipoprotein binding  tissue regeneration  fibrinolysis  cellular protein metabolic process  myoblast differentiation  muscle cell cellular homeostasis  tissue remodeling  proteolysis involved in cellular protein catabolic process  negative regulation of fibrinolysis  positive regulation of fibrinolysis  trophoblast giant cell differentiation  labyrinthine layer blood vessel development  extracellular vesicular exosome  mononuclear cell migration  blood microparticle  negative regulation of cell-cell adhesion mediated by cadherin  
Ontology : EGO-EBIplatelet degranulation  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  plasma membrane  blood coagulation  blood coagulation  serine-type peptidase activity  negative regulation of cell proliferation  cell surface  negative regulation of cell-substrate adhesion  protein domain specific binding  extracellular matrix disassembly  extracellular matrix disassembly  platelet activation  extracellular matrix organization  platelet alpha granule lumen  extrinsic component of external side of plasma membrane  apolipoprotein binding  tissue regeneration  fibrinolysis  cellular protein metabolic process  myoblast differentiation  muscle cell cellular homeostasis  tissue remodeling  proteolysis involved in cellular protein catabolic process  negative regulation of fibrinolysis  positive regulation of fibrinolysis  trophoblast giant cell differentiation  labyrinthine layer blood vessel development  extracellular vesicular exosome  mononuclear cell migration  blood microparticle  negative regulation of cell-cell adhesion mediated by cadherin  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]    Platelet Amyloid Precursor Protein Pathway [Genes]    Acute Myocardial Infarction [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction    Complement and coagulation cascades    Staphylococcus aureus infection    Influenza A   
Protein Interaction DatabasePLG
DoCM (Curated mutations)PLG
Wikipedia pathwaysPLG
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPLG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLG
dbVarPLG
ClinVarPLG
1000_GenomesPLG 
Exome Variant ServerPLG
SNP (GeneSNP Utah)PLG
SNP : HGBasePLG
Genetic variants : HAPMAPPLG
Genomic Variants (DGV)PLG [DGVbeta]
Mutations
ICGC Data PortalENSG00000122194 
Somatic Mutations in Cancer : COSMICPLG 
CONAN: Copy Number AnalysisPLG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:161123225-161175085
Mutations and Diseases : HGMDPLG
OMIM173350    217090   
MedgenPLG
NextProtP00747 [Medical]
GENETestsPLG
Disease Genetic AssociationPLG
Huge Navigator PLG [HugePedia]  PLG [HugeCancerGEM]
snp3D : Map Gene to Disease5340
DGIdb (Drug Gene Interaction db)PLG
General knowledge
Homologs : HomoloGenePLG
Homology/Alignments : Family Browser (UCSC)PLG
Phylogenetic Trees/Animal Genes : TreeFamPLG
Chemical/Protein Interactions : CTD5340
Chemical/Pharm GKB GenePA33405
Clinical trialPLG
Cancer Resource (Charite)ENSG00000122194
Other databases
Probes
Litterature
PubMed293 Pubmed reference(s) in Entrez
CoreMinePLG
GoPubMedPLG
iHOPPLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 18:01:49 CET 2015

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jlhuret@AtlasGeneticsOncology.org.