PLIN2 (perilipin 2)

2009-09-01  

Identity

HGNC
LOCATION
9p22.1
LOCUSID
ALIAS
ADFP,ADRP
FUSION GENES

Other Information

Locus ID:

NCBI: 123
MIM: 103195
HGNC: 248
Ensembl: ENSG00000147872

Variants:

dbSNP: 123
ClinVar: 123
TCGA: ENSG00000147872
COSMIC: PLIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147872ENST00000276914Q99541
ENSG00000147872ENST00000276914Q6FHZ7
ENSG00000147872ENST00000380464Q5SYF3
ENSG00000147872ENST00000380465Q5SYF4
ENSG00000147872ENST00000434144Q5SYF5

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183933902008Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis.78
125919292003Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein.74
147070382004Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis.53
162307422006ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.44
231297902013Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5.42
164892052006PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.41
196025602009Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.30
201433362010Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP).30
200325802009Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning.29
267428482016Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.27

Citation

Dessen P

PLIN2 (perilipin 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51097/plin2