Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PLK2 (polo-like kinase 2)

Identity

Other namesSNK
hPlk2
hSNK
HGNC (Hugo) PLK2
LocusID (NCBI) 10769
Location 5q11.2
Location_base_pair Starts at 57749810 and ends at 57755966 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLK2   19699
Entrez_Gene (NCBI)PLK2  10769  polo-like kinase 2
Cards
GeneCards (Weizmann)PLK2
Ensembl (Hinxton)ENSG00000145632 [Gene_View]  chr5:57749810-57755966 [Contig_View]  PLK2 [Vega]
AceView (NCBI)PLK2
Genatlas (Paris)PLK2
SOURCE (Stanford)NM_001252226 NM_006622
Genomic and cartography
GoldenPath (UCSC)PLK2  -  5q11.2   chr5:57749810-57755966 -  5q11.2   [Description]    (hg19-Feb_2009)
EnsemblPLK2 - 5q11.2 [CytoView]
Mapping of homologs : NCBIPLK2 [Mapview]
OMIM607023   
Gene and transcription
Genbank (Entrez)AA469989 AA954432 AF059617 AF223574 AI655395
RefSeq transcript (SRS)NM_001252226 NM_006622
RefSeq transcript (Entrez)NM_001252226 NM_006622
RefSeq genomic (SRS)AC_000137 NC_000005 NC_018916 NT_006713 NW_001838934 NW_004078023
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NT_006713 NW_001838934 NW_004078023
Consensus coding sequences : CCDS (NCBI)PLK2
Cluster EST : UnigeneHs.658132 [ SRS ] Hs.658132 [ NCBI ]
CGAP (NCI)Hs.658132
Alternative Splicing : Fast-db (Paris)GSHG0024806
Alternative Splicing GalleryENSG00000145632
Gene ExpressionPLK2 [ NCBI-GEO ]   PLK2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYY3 (SRS) Q9NYY3 (Uniprot)
NextProtQ9NYY3
With graphics : InterProQ9NYY3
Splice isoforms : SwissVarQ9NYY3(Swissvar)
Domaine pattern : Prosite (SRS)POLO_BOX (PS50078)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)POLO_BOX (PS50078)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    POLO_box_duplicated_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)Kinase-like_dom    POLO_box_duplicated_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ9NYY3
Domain families : Pfam (SRS)Pkinase (PF00069)    POLO_box (PF00659)   
Domain families : Pfam (Sanger)Pkinase (PF00069)    POLO_box (PF00659)   
Domain families : Pfam (NCBI)pfam00069    pfam00659   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM10769
Blocks (Seattle)Q9NYY3
Human Protein AtlasENSG00000145632
HPRD06118
IPIIPI00302787   IPI00908325   IPI01013453   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYY3
IntAct (EBI)Q9NYY3
FunCoupENSG00000145632
REACTOMEPLK2
Protein Interaction Database10769
BioGRIDPLK2
InParanoidQ9NYY3
Interologous Interaction database Q9NYY3
IntegromeDBPLK2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PLK2
SNP (GeneSNP Utah)PLK2
SNP : HGBasePLK2
Genetic variants : HAPMAPPLK2
Somatic Mutations in Cancer : COSMICPLK2 
CONAN: Copy Number AnalysisPLK2 
Mutations and Diseases : HGMDPLK2
OMIM607023   
GENETests607023   
Disease Genetic AssociationPLK2
Huge Navigator PLK2 [HugePedia]  PLK2 [HugeCancerGEM]
Genomic VariantsPLK2  PLK2 [DGVbeta]
snp3D : Map Gene to Disease10769
General knowledge
Homologs : HomoloGenePLK2
Homology/Alignments : Family Browser (UCSC)PLK2
Phylogenetic Trees/Animal Genes : TreeFamPLK2
Catalytic activity : Enzyme2.7.11.21 [ Enzyme-Expasy ]   2.7.11.21 [ Enzyme-SRS ]   2.7.11.21 [ IntEnz-EBI ]   2.7.11.21 [ BRENDA ]   2.7.11.21 [ KEGG ]   
Chemical/Protein Interactions : CTD10769
Chemical/Pharm GKB GenePA134940798
Clinical trialPLK2
Cancer Resource (Charite)ENSG00000145632
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  intracellular  centrosome  centriole  protein phosphorylation  mitotic spindle organization  mitotic cell cycle checkpoint  Ras protein signal transduction  memory  dendrite  Rap protein signal transduction  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB cascade  regulation of centriole replication  regulation of centriole replication  regulation of synaptic plasticity  long-term synaptic potentiation  long term synaptic depression  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  intracellular  centrosome  centriole  protein phosphorylation  mitotic spindle organization  mitotic cell cycle checkpoint  Ras protein signal transduction  memory  dendrite  Rap protein signal transduction  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB cascade  regulation of centriole replication  regulation of centriole replication  regulation of synaptic plasticity  long-term synaptic potentiation  long term synaptic depression  
Other databases
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
PubGenePLK2
iHOPPLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:39:37 CEST 2013
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