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PLK2 (polo like kinase 2)

Identity

Alias_namespolo-like kinase 2 (Drosophila)
polo-like kinase 2
Alias_symbol (synonym)SNK
Other aliashPlk2
hSNK
HGNC (Hugo) PLK2
LocusID (NCBI) 10769
Atlas_Id 49829
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 58453983 and ends at 58460139 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLK2   19699
Cards
Entrez_Gene (NCBI)PLK2  10769  polo like kinase 2
AliasesSNK; hPlk2; hSNK
GeneCards (Weizmann)PLK2
Ensembl hg19 (Hinxton)ENSG00000145632 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145632 [Gene_View]  chr5:58453983-58460139 [Contig_View]  PLK2 [Vega]
ICGC DataPortalENSG00000145632
TCGA cBioPortalPLK2
AceView (NCBI)PLK2
Genatlas (Paris)PLK2
WikiGenes10769
SOURCE (Princeton)PLK2
Genetics Home Reference (NIH)PLK2
Genomic and cartography
GoldenPath hg38 (UCSC)PLK2  -     chr5:58453983-58460139 -  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLK2  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblPLK2 - 5q11.2 [CytoView hg19]  PLK2 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIPLK2 [Mapview hg19]  PLK2 [Mapview hg38]
OMIM607023   
Gene and transcription
Genbank (Entrez)AA469989 AA954432 AF059617 AF223574 AI655395
RefSeq transcript (Entrez)NM_001252226 NM_006622
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLK2
Cluster EST : UnigeneHs.398157 [ NCBI ]
CGAP (NCI)Hs.398157
Alternative Splicing GalleryENSG00000145632
Gene ExpressionPLK2 [ NCBI-GEO ]   PLK2 [ EBI - ARRAY_EXPRESS ]   PLK2 [ SEEK ]   PLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10769
GTEX Portal (Tissue expression)PLK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYY3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYY3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYY3
Splice isoforms : SwissVarQ9NYY3
Catalytic activity : Enzyme2.7.11.21 [ Enzyme-Expasy ]   2.7.11.212.7.11.21 [ IntEnz-EBI ]   2.7.11.21 [ BRENDA ]   2.7.11.21 [ KEGG ]   
PhosPhoSitePlusQ9NYY3
Domaine pattern : Prosite (Expaxy)POLO_BOX (PS50078)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    POLO_box_1    POLO_box_2    POLO_box_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    POLO_box (PF00659)   
Domain families : Pfam (NCBI)pfam00069    pfam00659   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PLK2
DMDM Disease mutations10769
Blocks (Seattle)PLK2
PDB (SRS)4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
PDB (PDBSum)4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
PDB (IMB)4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
PDB (RSDB)4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
Structural Biology KnowledgeBase4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
SCOP (Structural Classification of Proteins)4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
CATH (Classification of proteins structures)4I5M    4I5P    4I6B    4I6F    4I6H    4RS6    4XB0   
SuperfamilyQ9NYY3
Human Protein AtlasENSG00000145632
Peptide AtlasQ9NYY3
HPRD06118
IPIIPI00302787   IPI00908325   IPI01013453   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYY3
IntAct (EBI)Q9NYY3
FunCoupENSG00000145632
BioGRIDPLK2
STRING (EMBL)PLK2
ZODIACPLK2
Ontologies - Pathways
QuickGOQ9NYY3
Ontology : AmiGOG1/S transition of mitotic cell cycle  chromatin  protein serine/threonine kinase activity  protein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  intracellular  cytoplasm  centrosome  centriole  cytosol  protein phosphorylation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  mitotic spindle organization  mitotic cell cycle checkpoint  Ras protein signal transduction  memory  positive regulation of autophagy  peptidyl-serine phosphorylation  dendrite  positive regulation of protein binding  protein complex binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  Rap protein signal transduction  ATP-dependent protein binding  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of protein catabolic process  regulation of centriole replication  regulation of centriole replication  regulation of synaptic plasticity  long-term synaptic potentiation  long term synaptic depression  negative regulation of dendritic spine development  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  chromatin  protein serine/threonine kinase activity  protein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  intracellular  cytoplasm  centrosome  centriole  cytosol  protein phosphorylation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  mitotic spindle organization  mitotic cell cycle checkpoint  Ras protein signal transduction  memory  positive regulation of autophagy  peptidyl-serine phosphorylation  dendrite  positive regulation of protein binding  protein complex binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  Rap protein signal transduction  ATP-dependent protein binding  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of protein catabolic process  regulation of centriole replication  regulation of centriole replication  regulation of synaptic plasticity  long-term synaptic potentiation  long term synaptic depression  negative regulation of dendritic spine development  
Pathways : KEGGFoxO signaling pathway   
NDEx NetworkPLK2
Atlas of Cancer Signalling NetworkPLK2
Wikipedia pathwaysPLK2
Orthology - Evolution
OrthoDB10769
GeneTree (enSembl)ENSG00000145632
Phylogenetic Trees/Animal Genes : TreeFamPLK2
HOVERGENQ9NYY3
HOGENOMQ9NYY3
Homologs : HomoloGenePLK2
Homology/Alignments : Family Browser (UCSC)PLK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLK2
dbVarPLK2
ClinVarPLK2
1000_GenomesPLK2 
Exome Variant ServerPLK2
ExAC (Exome Aggregation Consortium)PLK2 (select the gene name)
Genetic variants : HAPMAP10769
Genomic Variants (DGV)PLK2 [DGVbeta]
DECIPHERPLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLK2 
Mutations
ICGC Data PortalPLK2 
TCGA Data PortalPLK2 
Broad Tumor PortalPLK2
OASIS PortalPLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLK2
DgiDB (Drug Gene Interaction Database)PLK2
DoCM (Curated mutations)PLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLK2 (select a term)
intoGenPLK2
Cancer3DPLK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607023   
Orphanet
MedgenPLK2
Genetic Testing Registry PLK2
NextProtQ9NYY3 [Medical]
TSGene10769
GENETestsPLK2
Target ValidationPLK2
Huge Navigator PLK2 [HugePedia]
snp3D : Map Gene to Disease10769
BioCentury BCIQPLK2
ClinGenPLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10769
Chemical/Pharm GKB GenePA134940798
Clinical trialPLK2
Miscellaneous
canSAR (ICR)PLK2 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLK2
EVEXPLK2
GoPubMedPLK2
iHOPPLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:16 CEST 2017

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