PLK2 (polo like kinase 2)

2007-11-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
SNK,hPlk2,hSNK

Other Information

Locus ID:

NCBI: 10769
MIM: 607023
HGNC: 19699
Ensembl: ENSG00000145632

Variants:

dbSNP: 10769
ClinVar: 10769
TCGA: ENSG00000145632
COSMIC: PLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145632ENST00000274289Q9NYY3
ENSG00000145632ENST00000274289A0A024QZV1
ENSG00000145632ENST00000617412A0A087WUH9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190048162009Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.83
128971302003Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.66
221342382011Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.35
200542362009The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.33
267193322016Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.33
252390932014MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinoma.29
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
197065412009Polo-like kinases mediate cell survival in mitochondrial dysfunction.26
223997982012Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4).25
205313872010PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.23

Citation

Dessen P

PLK2 (polo like kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49829/plk2