Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLK3 (polo like kinase 3)

Identity

Alias (NCBI)CNK
FNK
PLK-3
PRK
HGNC (Hugo) PLK3
HGNC Alias symbFNK
PRK
HGNC Previous nameCNK
HGNC Previous namecytokine-inducible kinase
 polo-like kinase 3 (Drosophila)
 polo-like kinase 3
LocusID (NCBI) 1263
Atlas_Id 41748
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 44800377 and ends at 44805990 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLK3 (1p34.1) / PLK3 (1p34.1)PRKCI (3q26.2) / PLK3 (1p34.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLK3   2154
Cards
Entrez_Gene (NCBI)PLK3    polo like kinase 3
AliasesCNK; FNK; PLK-3; PRK
GeneCards (Weizmann)PLK3
Ensembl hg19 (Hinxton)ENSG00000173846 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173846 [Gene_View]  ENSG00000173846 [Sequence]  chr1:44800377-44805990 [Contig_View]  PLK3 [Vega]
ICGC DataPortalENSG00000173846
TCGA cBioPortalPLK3
AceView (NCBI)PLK3
Genatlas (Paris)PLK3
SOURCE (Princeton)PLK3
Genetics Home Reference (NIH)PLK3
Genomic and cartography
GoldenPath hg38 (UCSC)PLK3  -     chr1:44800377-44805990 +  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLK3  -     1p34.1   [Description]    (hg19-Feb_2009)
GoldenPathPLK3 - 1p34.1 [CytoView hg19]  PLK3 - 1p34.1 [CytoView hg38]
ImmunoBaseENSG00000173846
Genome Data Viewer NCBIPLK3 [Mapview hg19]  
OMIM602913   
Gene and transcription
Genbank (Entrez)AA421212 AB209875 AJ293866 AL157684 BC004135
RefSeq transcript (Entrez)NM_004073
Consensus coding sequences : CCDS (NCBI)PLK3
Gene ExpressionPLK3 [ NCBI-GEO ]   PLK3 [ EBI - ARRAY_EXPRESS ]   PLK3 [ SEEK ]   PLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLK3 [ Firebrowse - Broad ]
GenevisibleExpression of PLK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1263
GTEX Portal (Tissue expression)PLK3
Human Protein AtlasENSG00000173846-PLK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H4B4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H4B4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H4B4
Catalytic activity : Enzyme2.7.11.21 [ Enzyme-Expasy ]   2.7.11.212.7.11.21 [ IntEnz-EBI ]   2.7.11.21 [ BRENDA ]   2.7.11.21 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H4B4
Domaine pattern : Prosite (Expaxy)POLO_BOX (PS50078)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PLK3_STKc    POLO_box_1    POLO_box_2    POLO_box_dom    POLO_box_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Ser/Thr_kinase_Plk3   
Domain families : Pfam (Sanger)Pkinase (PF00069)    POLO_box (PF00659)   
Domain families : Pfam (NCBI)pfam00069    pfam00659   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PLK3
PDB (RSDB)4B6L   
PDB Europe4B6L   
PDB (PDBSum)4B6L   
PDB (IMB)4B6L   
Structural Biology KnowledgeBase4B6L   
SCOP (Structural Classification of Proteins)4B6L   
CATH (Classification of proteins structures)4B6L   
SuperfamilyQ9H4B4
AlphaFold pdb e-kbQ9H4B4   
Human Protein Atlas [tissue]ENSG00000173846-PLK3 [tissue]
HPRD04222
Protein Interaction databases
DIP (DOE-UCLA)Q9H4B4
IntAct (EBI)Q9H4B4
BioGRIDPLK3
STRING (EMBL)PLK3
ZODIACPLK3
Ontologies - Pathways
QuickGOQ9H4B4
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  mitotic cell cycle  response to reactive oxygen species  spindle pole  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  Golgi stack  centrosome  centrosome  protein phosphorylation  apoptotic process  response to osmotic stress  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  endomitotic cell cycle  response to radiation  dendrite  cytoplasmic microtubule organization  regulation of cytokinesis  regulation of cytokinesis  regulation of cytokinesis  neuronal cell body  negative regulation of apoptotic process  protein kinase B signaling  mitotic G1/S transition checkpoint signaling  mitotic G1/S transition checkpoint signaling  regulation of cell division  Golgi disassembly  Golgi disassembly  positive regulation of intracellular protein transport  protein serine kinase activity  protein threonine kinase activity  regulation of signal transduction by p53 class mediator  positive regulation of chaperone-mediated autophagy  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  mitotic cell cycle  response to reactive oxygen species  spindle pole  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  Golgi stack  centrosome  centrosome  protein phosphorylation  apoptotic process  response to osmotic stress  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  endomitotic cell cycle  response to radiation  dendrite  cytoplasmic microtubule organization  regulation of cytokinesis  regulation of cytokinesis  regulation of cytokinesis  neuronal cell body  negative regulation of apoptotic process  protein kinase B signaling  mitotic G1/S transition checkpoint signaling  mitotic G1/S transition checkpoint signaling  regulation of cell division  Golgi disassembly  Golgi disassembly  positive regulation of intracellular protein transport  protein serine kinase activity  protein threonine kinase activity  regulation of signal transduction by p53 class mediator  positive regulation of chaperone-mediated autophagy  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
Pathways : BIOCARTARegulation of cell cycle progression by Plk3 [Genes]   
Pathways : KEGGFoxO signaling pathway    Tuberculosis   
NDEx NetworkPLK3
Atlas of Cancer Signalling NetworkPLK3
Wikipedia pathwaysPLK3
Orthology - Evolution
OrthoDB1263
GeneTree (enSembl)ENSG00000173846
Phylogenetic Trees/Animal Genes : TreeFamPLK3
Homologs : HomoloGenePLK3
Homology/Alignments : Family Browser (UCSC)PLK3
Gene fusions - Rearrangements
Fusion : QuiverPLK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLK3
dbVarPLK3
ClinVarPLK3
MonarchPLK3
1000_GenomesPLK3 
Exome Variant ServerPLK3
GNOMAD BrowserENSG00000173846
Varsome BrowserPLK3
ACMGPLK3 variants
VarityQ9H4B4
Genomic Variants (DGV)PLK3 [DGVbeta]
DECIPHERPLK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLK3 
Mutations
ICGC Data PortalPLK3 
TCGA Data PortalPLK3 
Broad Tumor PortalPLK3
OASIS PortalPLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLK3
Mutations and Diseases : HGMDPLK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLK3
DgiDB (Drug Gene Interaction Database)PLK3
DoCM (Curated mutations)PLK3
CIViC (Clinical Interpretations of Variants in Cancer)PLK3
Cancer3DPLK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602913   
Orphanet
DisGeNETPLK3
MedgenPLK3
Genetic Testing Registry PLK3
NextProtQ9H4B4 [Medical]
GENETestsPLK3
Target ValidationPLK3
Huge Navigator PLK3 [HugePedia]
ClinGenPLK3
Clinical trials, drugs, therapy
MyCancerGenomePLK3
Protein Interactions : CTDPLK3
Pharm GKB GenePA26664
PharosQ9H4B4
Clinical trialPLK3
Miscellaneous
canSAR (ICR)PLK3
HarmonizomePLK3
DataMed IndexPLK3
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:44 CEST 2021

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