Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLK3 (polo like kinase 3)

Identity

Alias_namesCNK
cytokine-inducible kinase
polo-like kinase 3 (Drosophila)
polo-like kinase 3
Alias_symbol (synonym)FNK
PRK
Other aliasPLK-3
HGNC (Hugo) PLK3
LocusID (NCBI) 1263
Atlas_Id 41748
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 44800225 and ends at 44805995 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLK3 (1p34.1) / PLK3 (1p34.1)PRKCI (3q26.2) / PLK3 (1p34.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLK3   2154
Cards
Entrez_Gene (NCBI)PLK3  1263  polo like kinase 3
AliasesCNK; FNK; PLK-3; PRK
GeneCards (Weizmann)PLK3
Ensembl hg19 (Hinxton)ENSG00000173846 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173846 [Gene_View]  chr1:44800225-44805995 [Contig_View]  PLK3 [Vega]
ICGC DataPortalENSG00000173846
TCGA cBioPortalPLK3
AceView (NCBI)PLK3
Genatlas (Paris)PLK3
WikiGenes1263
SOURCE (Princeton)PLK3
Genetics Home Reference (NIH)PLK3
Genomic and cartography
GoldenPath hg38 (UCSC)PLK3  -     chr1:44800225-44805995 +  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLK3  -     1p34.1   [Description]    (hg19-Feb_2009)
EnsemblPLK3 - 1p34.1 [CytoView hg19]  PLK3 - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBIPLK3 [Mapview hg19]  PLK3 [Mapview hg38]
OMIM602913   
Gene and transcription
Genbank (Entrez)AA421212 AB209875 AJ293866 AL157684 BC004135
RefSeq transcript (Entrez)NM_004073
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLK3
Cluster EST : UnigeneHs.632415 [ NCBI ]
CGAP (NCI)Hs.632415
Alternative Splicing GalleryENSG00000173846
Gene ExpressionPLK3 [ NCBI-GEO ]   PLK3 [ EBI - ARRAY_EXPRESS ]   PLK3 [ SEEK ]   PLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1263
GTEX Portal (Tissue expression)PLK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H4B4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H4B4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H4B4
Splice isoforms : SwissVarQ9H4B4
Catalytic activity : Enzyme2.7.11.21 [ Enzyme-Expasy ]   2.7.11.212.7.11.21 [ IntEnz-EBI ]   2.7.11.21 [ BRENDA ]   2.7.11.21 [ KEGG ]   
PhosPhoSitePlusQ9H4B4
Domaine pattern : Prosite (Expaxy)POLO_BOX (PS50078)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    POLO_box_1    POLO_box_2    POLO_box_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Ser/Thr_kinase_Plk3   
Domain families : Pfam (Sanger)Pkinase (PF00069)    POLO_box (PF00659)   
Domain families : Pfam (NCBI)pfam00069    pfam00659   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PLK3
DMDM Disease mutations1263
Blocks (Seattle)PLK3
PDB (SRS)4B6L   
PDB (PDBSum)4B6L   
PDB (IMB)4B6L   
PDB (RSDB)4B6L   
Structural Biology KnowledgeBase4B6L   
SCOP (Structural Classification of Proteins)4B6L   
CATH (Classification of proteins structures)4B6L   
SuperfamilyQ9H4B4
Human Protein AtlasENSG00000173846
Peptide AtlasQ9H4B4
HPRD04222
IPIIPI00304186   IPI00981562   
Protein Interaction databases
DIP (DOE-UCLA)Q9H4B4
IntAct (EBI)Q9H4B4
FunCoupENSG00000173846
BioGRIDPLK3
STRING (EMBL)PLK3
ZODIACPLK3
Ontologies - Pathways
QuickGOQ9H4B4
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  response to reactive oxygen species  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  Golgi stack  centrosome  protein phosphorylation  apoptotic process  response to osmotic stress  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  mitotic cell cycle checkpoint  endomitotic cell cycle  response to radiation  dendrite  cytoplasmic microtubule organization  regulation of cytokinesis  regulation of cytokinesis  neuronal cell body  negative regulation of apoptotic process  protein kinase B signaling  mitotic G1/S transition checkpoint  regulation of cell division  Golgi disassembly  positive regulation of intracellular protein transport  regulation of signal transduction by p53 class mediator  positive regulation of chaperone-mediated autophagy  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  response to reactive oxygen species  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  Golgi stack  centrosome  protein phosphorylation  apoptotic process  response to osmotic stress  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  mitotic cell cycle checkpoint  endomitotic cell cycle  response to radiation  dendrite  cytoplasmic microtubule organization  regulation of cytokinesis  regulation of cytokinesis  neuronal cell body  negative regulation of apoptotic process  protein kinase B signaling  mitotic G1/S transition checkpoint  regulation of cell division  Golgi disassembly  positive regulation of intracellular protein transport  regulation of signal transduction by p53 class mediator  positive regulation of chaperone-mediated autophagy  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
Pathways : BIOCARTARegulation of cell cycle progression by Plk3 [Genes]   
Pathways : KEGGFoxO signaling pathway    Tuberculosis   
NDEx NetworkPLK3
Atlas of Cancer Signalling NetworkPLK3
Wikipedia pathwaysPLK3
Orthology - Evolution
OrthoDB1263
GeneTree (enSembl)ENSG00000173846
Phylogenetic Trees/Animal Genes : TreeFamPLK3
HOVERGENQ9H4B4
HOGENOMQ9H4B4
Homologs : HomoloGenePLK3
Homology/Alignments : Family Browser (UCSC)PLK3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLK3
dbVarPLK3
ClinVarPLK3
1000_GenomesPLK3 
Exome Variant ServerPLK3
ExAC (Exome Aggregation Consortium)PLK3 (select the gene name)
Genetic variants : HAPMAP1263
Genomic Variants (DGV)PLK3 [DGVbeta]
DECIPHERPLK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLK3 
Mutations
ICGC Data PortalPLK3 
TCGA Data PortalPLK3 
Broad Tumor PortalPLK3
OASIS PortalPLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLK3
DgiDB (Drug Gene Interaction Database)PLK3
DoCM (Curated mutations)PLK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLK3 (select a term)
intoGenPLK3
Cancer3DPLK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602913   
Orphanet
MedgenPLK3
Genetic Testing Registry PLK3
NextProtQ9H4B4 [Medical]
TSGene1263
GENETestsPLK3
Target ValidationPLK3
Huge Navigator PLK3 [HugePedia]
snp3D : Map Gene to Disease1263
BioCentury BCIQPLK3
ClinGenPLK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1263
Chemical/Pharm GKB GenePA26664
Clinical trialPLK3
Miscellaneous
canSAR (ICR)PLK3 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLK3
EVEXPLK3
GoPubMedPLK3
iHOPPLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:49:54 CEST 2017

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