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PLPP1 (phospholipid phosphatase 1)

Identity

Alias_namesPPAP2A
phosphatidic acid phosphatase type 2A
Alias_symbol (synonym)PAP-2a
LPP1
Other aliasLLP1a
PAP2
HGNC (Hugo) PLPP1
LocusID (NCBI) 8611
Atlas_Id 41790
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55424842 and ends at 55535078 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAM23 (2q33.3) / PLPP1 (5q11.2)ARFGEF1 (8q13.2) / PLPP1 (5q11.2)GGCT (7p14.3) / PLPP1 (5q11.2)
PDE4D (5q11.2) / PLPP1 (5q11.2)PLPP1 (5q11.2) / ADCY2 (5p15.31)PLPP1 (5q11.2) / MLPH (2q37.3)
PLPP1 (5q11.2) / SREK1IP1 (5q12.3)SPTLC3 (20p12.1) / PLPP1 (5q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLPP1   9228
Cards
Entrez_Gene (NCBI)PLPP1  8611  phospholipid phosphatase 1
AliasesLLP1a; LPP1; PAP-2a; PAP2; 
PPAP2A
GeneCards (Weizmann)PLPP1
Ensembl hg19 (Hinxton)ENSG00000067113 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000067113 [Gene_View]  chr5:55424842-55535078 [Contig_View]  PLPP1 [Vega]
ICGC DataPortalENSG00000067113
TCGA cBioPortalPLPP1
AceView (NCBI)PLPP1
Genatlas (Paris)PLPP1
WikiGenes8611
SOURCE (Princeton)PLPP1
Genetics Home Reference (NIH)PLPP1
Genomic and cartography
GoldenPath hg38 (UCSC)PLPP1  -     chr5:55424842-55535078 -  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLPP1  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblPLPP1 - 5q11.2 [CytoView hg19]  PLPP1 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIPLPP1 [Mapview hg19]  PLPP1 [Mapview hg38]
OMIM607124   
Gene and transcription
Genbank (Entrez)AB000888 AF014402 AF014403 AF017116 AK124204
RefSeq transcript (Entrez)NM_003711 NM_176895
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLPP1
Cluster EST : UnigeneHs.696231 [ NCBI ]
CGAP (NCI)Hs.696231
Alternative Splicing GalleryENSG00000067113
Gene ExpressionPLPP1 [ NCBI-GEO ]   PLPP1 [ EBI - ARRAY_EXPRESS ]   PLPP1 [ SEEK ]   PLPP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLPP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8611
GTEX Portal (Tissue expression)PLPP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14494   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14494  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14494
Splice isoforms : SwissVarO14494
Catalytic activity : Enzyme3.1.3.4 [ Enzyme-Expasy ]   3.1.3.43.1.3.4 [ IntEnz-EBI ]   3.1.3.4 [ BRENDA ]   3.1.3.4 [ KEGG ]   
PhosPhoSitePlusO14494
Domains : Interpro (EBI)LPP1    P_Acid_Pase_2/haloperoxidase   
Domain families : Pfam (Sanger)PAP2 (PF01569)   
Domain families : Pfam (NCBI)pfam01569   
Domain families : Smart (EMBL)acidPPc (SM00014)  
Conserved Domain (NCBI)PLPP1
DMDM Disease mutations8611
Blocks (Seattle)PLPP1
SuperfamilyO14494
Human Protein AtlasENSG00000067113
Peptide AtlasO14494
HPRD06178
IPIIPI00297037   IPI00409585   IPI00965081   
Protein Interaction databases
DIP (DOE-UCLA)O14494
IntAct (EBI)O14494
FunCoupENSG00000067113
BioGRIDPLPP1
STRING (EMBL)PLPP1
ZODIACPLPP1
Ontologies - Pathways
QuickGOO14494
Ontology : AmiGOplasma membrane  integral component of plasma membrane  integral component of plasma membrane  protein dephosphorylation  lipid metabolic process  phospholipid metabolic process  protein kinase C-activating G-protein coupled receptor signaling pathway  phosphatidate phosphatase activity  phosphatidate phosphatase activity  negative regulation of cell proliferation  germ cell migration  membrane  regulation of lipid metabolic process  sphingolipid biosynthetic process  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  phospholipid dephosphorylation  extracellular exosome  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  integral component of plasma membrane  protein dephosphorylation  lipid metabolic process  phospholipid metabolic process  protein kinase C-activating G-protein coupled receptor signaling pathway  phosphatidate phosphatase activity  phosphatidate phosphatase activity  negative regulation of cell proliferation  germ cell migration  membrane  regulation of lipid metabolic process  sphingolipid biosynthetic process  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  phospholipid dephosphorylation  extracellular exosome  
NDEx NetworkPLPP1
Atlas of Cancer Signalling NetworkPLPP1
Wikipedia pathwaysPLPP1
Orthology - Evolution
OrthoDB8611
GeneTree (enSembl)ENSG00000067113
Phylogenetic Trees/Animal Genes : TreeFamPLPP1
HOVERGENO14494
HOGENOMO14494
Homologs : HomoloGenePLPP1
Homology/Alignments : Family Browser (UCSC)PLPP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLPP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLPP1
dbVarPLPP1
ClinVarPLPP1
1000_GenomesPLPP1 
Exome Variant ServerPLPP1
ExAC (Exome Aggregation Consortium)PLPP1 (select the gene name)
Genetic variants : HAPMAP8611
Genomic Variants (DGV)PLPP1 [DGVbeta]
DECIPHERPLPP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLPP1 
Mutations
ICGC Data PortalPLPP1 
TCGA Data PortalPLPP1 
Broad Tumor PortalPLPP1
OASIS PortalPLPP1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLPP1
BioMutasearch PLPP1
DgiDB (Drug Gene Interaction Database)PLPP1
DoCM (Curated mutations)PLPP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLPP1 (select a term)
intoGenPLPP1
Cancer3DPLPP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607124   
Orphanet
MedgenPLPP1
Genetic Testing Registry PLPP1
NextProtO14494 [Medical]
TSGene8611
GENETestsPLPP1
Target ValidationPLPP1
Huge Navigator PLPP1 [HugePedia]
snp3D : Map Gene to Disease8611
BioCentury BCIQPLPP1
ClinGenPLPP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8611
Chemical/Pharm GKB GenePA33552
Clinical trialPLPP1
Miscellaneous
canSAR (ICR)PLPP1 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLPP1
EVEXPLPP1
GoPubMedPLPP1
iHOPPLPP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:57 CEST 2017

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