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PLPP1 (phospholipid phosphatase 1)

Identity

Alias (NCBI)LLP1a
LPP1
PAP-2a
PAP2
PPAP2A
HGNC (Hugo) PLPP1
HGNC Alias symbPAP-2a
LPP1
HGNC Previous namePPAP2A
HGNC Previous namephosphatidic acid phosphatase type 2A
LocusID (NCBI) 8611
Atlas_Id 41790
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55424842 and ends at 55535078 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM23 (2q33.3) / PLPP1 (5q11.2)ARFGEF1 (8q13.2) / PLPP1 (5q11.2)GGCT (7p14.3) / PLPP1 (5q11.2)
PDE4D (5q11.2) / PLPP1 (5q11.2)PLPP1 (5q11.2) / ADCY2 (5p15.31)PLPP1 (5q11.2) / MLPH (2q37.3)
PLPP1 (5q11.2) / SREK1IP1 (5q12.3)SPTLC3 (20p12.1) / PLPP1 (5q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLPP1   9228
Cards
Entrez_Gene (NCBI)PLPP1    phospholipid phosphatase 1
AliasesLLP1a; LPP1; PAP-2a; PAP2; 
PPAP2A
GeneCards (Weizmann)PLPP1
Ensembl hg19 (Hinxton)ENSG00000067113 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000067113 [Gene_View]  ENSG00000067113 [Sequence]  chr5:55424842-55535078 [Contig_View]  PLPP1 [Vega]
ICGC DataPortalENSG00000067113
TCGA cBioPortalPLPP1
AceView (NCBI)PLPP1
Genatlas (Paris)PLPP1
SOURCE (Princeton)PLPP1
Genetics Home Reference (NIH)PLPP1
Genomic and cartography
GoldenPath hg38 (UCSC)PLPP1  -     chr5:55424842-55535078 -  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLPP1  -     5q11.2   [Description]    (hg19-Feb_2009)
GoldenPathPLPP1 - 5q11.2 [CytoView hg19]  PLPP1 - 5q11.2 [CytoView hg38]
ImmunoBaseENSG00000067113
Genome Data Viewer NCBIPLPP1 [Mapview hg19]  
OMIM607124   
Gene and transcription
Genbank (Entrez)AB000888 AF014402 AF014403 AF017116 AK124204
RefSeq transcript (Entrez)NM_003711 NM_176895
Consensus coding sequences : CCDS (NCBI)PLPP1
Gene ExpressionPLPP1 [ NCBI-GEO ]   PLPP1 [ EBI - ARRAY_EXPRESS ]   PLPP1 [ SEEK ]   PLPP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLPP1 [ Firebrowse - Broad ]
GenevisibleExpression of PLPP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8611
GTEX Portal (Tissue expression)PLPP1
Human Protein AtlasENSG00000067113-PLPP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14494   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14494  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14494
PhosPhoSitePlusO14494
Domains : Interpro (EBI)LPP1    P_Acid_Pase_2/haloperoxi_sf    P_Acid_Pase_2/haloperoxidase    PLPP   
Domain families : Pfam (Sanger)PAP2 (PF01569)   
Domain families : Pfam (NCBI)pfam01569   
Domain families : Smart (EMBL)acidPPc (SM00014)  
Conserved Domain (NCBI)PLPP1
SuperfamilyO14494
AlphaFold pdb e-kbO14494   
Human Protein Atlas [tissue]ENSG00000067113-PLPP1 [tissue]
HPRD06178
Protein Interaction databases
DIP (DOE-UCLA)O14494
IntAct (EBI)O14494
BioGRIDPLPP1
STRING (EMBL)PLPP1
ZODIACPLPP1
Ontologies - Pathways
QuickGOO14494
Ontology : AmiGOdiacylglycerol diphosphate phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  caveola  phospholipid metabolic process  phospholipid metabolic process  phospholipid metabolic process  sphingosine metabolic process  ceramide metabolic process  signal transduction  signal transduction  protein kinase C-activating G protein-coupled receptor signaling pathway  phosphatidate phosphatase activity  phosphatidate phosphatase activity  phosphatidate phosphatase activity  negative regulation of cell population proliferation  membrane  apical plasma membrane  regulation of lipid metabolic process  sphingolipid biosynthetic process  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  lipid phosphatase activity  membrane raft  phospholipid dephosphorylation  phospholipid dephosphorylation  phospholipid dephosphorylation  extracellular exosome  ceramide-1-phosphate phosphatase activity  
Ontology : EGO-EBIdiacylglycerol diphosphate phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  caveola  phospholipid metabolic process  phospholipid metabolic process  phospholipid metabolic process  sphingosine metabolic process  ceramide metabolic process  signal transduction  signal transduction  protein kinase C-activating G protein-coupled receptor signaling pathway  phosphatidate phosphatase activity  phosphatidate phosphatase activity  phosphatidate phosphatase activity  negative regulation of cell population proliferation  membrane  apical plasma membrane  regulation of lipid metabolic process  sphingolipid biosynthetic process  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  lipid phosphatase activity  membrane raft  phospholipid dephosphorylation  phospholipid dephosphorylation  phospholipid dephosphorylation  extracellular exosome  ceramide-1-phosphate phosphatase activity  
NDEx NetworkPLPP1
Atlas of Cancer Signalling NetworkPLPP1
Wikipedia pathwaysPLPP1
Orthology - Evolution
OrthoDB8611
GeneTree (enSembl)ENSG00000067113
Phylogenetic Trees/Animal Genes : TreeFamPLPP1
Homologs : HomoloGenePLPP1
Homology/Alignments : Family Browser (UCSC)PLPP1
Gene fusions - Rearrangements
Fusion : QuiverPLPP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLPP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLPP1
dbVarPLPP1
ClinVarPLPP1
MonarchPLPP1
1000_GenomesPLPP1 
Exome Variant ServerPLPP1
GNOMAD BrowserENSG00000067113
Varsome BrowserPLPP1
ACMGPLPP1 variants
VarityO14494
Genomic Variants (DGV)PLPP1 [DGVbeta]
DECIPHERPLPP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLPP1 
Mutations
ICGC Data PortalPLPP1 
TCGA Data PortalPLPP1 
Broad Tumor PortalPLPP1
OASIS PortalPLPP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLPP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLPP1
Mutations and Diseases : HGMDPLPP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLPP1
DgiDB (Drug Gene Interaction Database)PLPP1
DoCM (Curated mutations)PLPP1
CIViC (Clinical Interpretations of Variants in Cancer)PLPP1
Cancer3DPLPP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607124   
Orphanet
DisGeNETPLPP1
MedgenPLPP1
Genetic Testing Registry PLPP1
NextProtO14494 [Medical]
GENETestsPLPP1
Target ValidationPLPP1
Huge Navigator PLPP1 [HugePedia]
ClinGenPLPP1
Clinical trials, drugs, therapy
MyCancerGenomePLPP1
Protein Interactions : CTDPLPP1
Pharm GKB GenePA33552
PharosO14494
Clinical trialPLPP1
Miscellaneous
canSAR (ICR)PLPP1
HarmonizomePLPP1
DataMed IndexPLPP1
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLPP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:46 CEST 2021

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