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PLPP2 (phospholipid phosphatase 2)

Identity

Alias_namesPPAP2C
phosphatidic acid phosphatase type 2C
Alias_symbol (synonym)PAP-2c
LPP2
Other aliasPAP2-g
HGNC (Hugo) PLPP2
LocusID (NCBI) 8612
Atlas_Id 77948
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 281040 and ends at 291435 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SLC39A3 (19p13.3) / PLPP2 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLPP2   9230
Cards
Entrez_Gene (NCBI)PLPP2  8612  phospholipid phosphatase 2
AliasesLPP2; PAP-2c; PAP2-g; PPAP2C
GeneCards (Weizmann)PLPP2
Ensembl hg19 (Hinxton)ENSG00000141934 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141934 [Gene_View]  chr19:281040-291435 [Contig_View]  PLPP2 [Vega]
ICGC DataPortalENSG00000141934
TCGA cBioPortalPLPP2
AceView (NCBI)PLPP2
Genatlas (Paris)PLPP2
WikiGenes8612
SOURCE (Princeton)PLPP2
Genetics Home Reference (NIH)PLPP2
Genomic and cartography
GoldenPath hg38 (UCSC)PLPP2  -     chr19:281040-291435 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLPP2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblPLPP2 - 19p13.3 [CytoView hg19]  PLPP2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIPLPP2 [Mapview hg19]  PLPP2 [Mapview hg38]
OMIM607126   
Gene and transcription
Genbank (Entrez)AA428937 AB209696 AF035959 AF047760 AF056083
RefSeq transcript (Entrez)NM_003712 NM_177526 NM_177543
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLPP2
Cluster EST : UnigeneHs.465506 [ NCBI ]
CGAP (NCI)Hs.465506
Alternative Splicing GalleryENSG00000141934
Gene ExpressionPLPP2 [ NCBI-GEO ]   PLPP2 [ EBI - ARRAY_EXPRESS ]   PLPP2 [ SEEK ]   PLPP2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLPP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8612
GTEX Portal (Tissue expression)PLPP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43688   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43688  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43688
Splice isoforms : SwissVarO43688
Catalytic activity : Enzyme3.1.3.4 [ Enzyme-Expasy ]   3.1.3.43.1.3.4 [ IntEnz-EBI ]   3.1.3.4 [ BRENDA ]   3.1.3.4 [ KEGG ]   
PhosPhoSitePlusO43688
Domains : Interpro (EBI)LPP2    P_Acid_Pase_2/haloperoxidase   
Domain families : Pfam (Sanger)PAP2 (PF01569)   
Domain families : Pfam (NCBI)pfam01569   
Domain families : Smart (EMBL)acidPPc (SM00014)  
Conserved Domain (NCBI)PLPP2
DMDM Disease mutations8612
Blocks (Seattle)PLPP2
SuperfamilyO43688
Human Protein AtlasENSG00000141934
Peptide AtlasO43688
HPRD06180
IPIIPI00216620   IPI00334058   IPI00556105   IPI00376858   
Protein Interaction databases
DIP (DOE-UCLA)O43688
IntAct (EBI)O43688
FunCoupENSG00000141934
BioGRIDPLPP2
STRING (EMBL)PLPP2
ZODIACPLPP2
Ontologies - Pathways
QuickGOO43688
Ontology : AmiGOphosphoprotein phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  protein dephosphorylation  phospholipid metabolic process  signal transduction  phosphatidate phosphatase activity  membrane  sphingolipid biosynthetic process  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  phospholipid dephosphorylation  
Ontology : EGO-EBIphosphoprotein phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  protein dephosphorylation  phospholipid metabolic process  signal transduction  phosphatidate phosphatase activity  membrane  sphingolipid biosynthetic process  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  phospholipid dephosphorylation  
NDEx NetworkPLPP2
Atlas of Cancer Signalling NetworkPLPP2
Wikipedia pathwaysPLPP2
Orthology - Evolution
OrthoDB8612
GeneTree (enSembl)ENSG00000141934
Phylogenetic Trees/Animal Genes : TreeFamPLPP2
HOVERGENO43688
HOGENOMO43688
Homologs : HomoloGenePLPP2
Homology/Alignments : Family Browser (UCSC)PLPP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLPP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLPP2
dbVarPLPP2
ClinVarPLPP2
1000_GenomesPLPP2 
Exome Variant ServerPLPP2
ExAC (Exome Aggregation Consortium)PLPP2 (select the gene name)
Genetic variants : HAPMAP8612
Genomic Variants (DGV)PLPP2 [DGVbeta]
DECIPHERPLPP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLPP2 
Mutations
ICGC Data PortalPLPP2 
TCGA Data PortalPLPP2 
Broad Tumor PortalPLPP2
OASIS PortalPLPP2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLPP2
BioMutasearch PLPP2
DgiDB (Drug Gene Interaction Database)PLPP2
DoCM (Curated mutations)PLPP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLPP2 (select a term)
intoGenPLPP2
Cancer3DPLPP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607126   
Orphanet
MedgenPLPP2
Genetic Testing Registry PLPP2
NextProtO43688 [Medical]
TSGene8612
GENETestsPLPP2
Target ValidationPLPP2
Huge Navigator PLPP2 [HugePedia]
snp3D : Map Gene to Disease8612
BioCentury BCIQPLPP2
ClinGenPLPP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8612
Chemical/Pharm GKB GenePA33554
Clinical trialPLPP2
Miscellaneous
canSAR (ICR)PLPP2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLPP2
EVEXPLPP2
GoPubMedPLPP2
iHOPPLPP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:36:40 CEST 2017

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