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PLPP3 (phospholipid phosphatase 3)

Identity

Alias_namesPPAP2B
phosphatidic acid phosphatase type 2B
Alias_symbol (synonym)PAP-2b
LPP3
Other aliasDri42
PAP2B
VCIP
HGNC (Hugo) PLPP3
LocusID (NCBI) 8613
Atlas_Id 41791
Location 1p32.2  [Link to chromosome band 1p32]
Location_base_pair Starts at 56960419 and ends at 57045257 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CANX (5q35.3) / PLPP3 (1p32.2)HMGA2 (12q14.3) / PLPP3 (1p32.2)NOP56 (20p13) / PLPP3 (1p32.2)
PLPP3 (1p32.2) / CALM3 (19q13.32)PLPP3 (1p32.2) / FOXP1 (3p13)PLPP3 (1p32.2) / PHPT1 (9q34.3)
PLPP3 (1p32.2) / PLPP3 (1p32.2)WDR26 (1q42.11) / PLPP3 (1p32.2)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Soft Tissues: Ordinary lipoma with t(1;12)(p32;q14) HMGA2/PPAP2B
Soft tissue tumors: an overview


External links

Nomenclature
HGNC (Hugo)PLPP3   9229
Cards
Entrez_Gene (NCBI)PLPP3  8613  phospholipid phosphatase 3
AliasesDri42; LPP3; PAP2B; PPAP2B; 
VCIP
GeneCards (Weizmann)PLPP3
Ensembl hg19 (Hinxton)ENSG00000162407 [Gene_View]  chr1:56960419-57045257 [Contig_View]  PLPP3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000162407 [Gene_View]  chr1:56960419-57045257 [Contig_View]  PLPP3 [Vega]
ICGC DataPortalENSG00000162407
TCGA cBioPortalPLPP3
AceView (NCBI)PLPP3
Genatlas (Paris)PLPP3
WikiGenes8613
SOURCE (Princeton)PLPP3
Genetics Home Reference (NIH)PLPP3
Genomic and cartography
GoldenPath hg19 (UCSC)PLPP3  -     chr1:56960419-57045257 -  1p32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLPP3  -     1p32.2   [Description]    (hg38-Dec_2013)
EnsemblPLPP3 - 1p32.2 [CytoView hg19]  PLPP3 - 1p32.2 [CytoView hg38]
Mapping of homologs : NCBIPLPP3 [Mapview hg19]  PLPP3 [Mapview hg38]
OMIM607125   
Gene and transcription
Genbank (Entrez)AB000889 AF017786 AF043329 AF480883 AK123105
RefSeq transcript (Entrez)NM_003713 NM_177414
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)PLPP3
Cluster EST : UnigeneHs.619002 [ NCBI ]
CGAP (NCI)Hs.619002
Alternative Splicing GalleryENSG00000162407
Gene ExpressionPLPP3 [ NCBI-GEO ]   PLPP3 [ EBI - ARRAY_EXPRESS ]   PLPP3 [ SEEK ]   PLPP3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLPP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8613
GTEX Portal (Tissue expression)PLPP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14495   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14495  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14495
Splice isoforms : SwissVarO14495
Catalytic activity : Enzyme3.1.3.4 [ Enzyme-Expasy ]   3.1.3.43.1.3.4 [ IntEnz-EBI ]   3.1.3.4 [ BRENDA ]   3.1.3.4 [ KEGG ]   
PhosPhoSitePlusO14495
Domains : Interpro (EBI)LPP3    P_Acid_Pase_2/haloperoxidase   
Domain families : Pfam (Sanger)PAP2 (PF01569)   
Domain families : Pfam (NCBI)pfam01569   
Domain families : Smart (EMBL)acidPPc (SM00014)  
Conserved Domain (NCBI)PLPP3
DMDM Disease mutations8613
Blocks (Seattle)PLPP3
SuperfamilyO14495
Human Protein AtlasENSG00000162407
Peptide AtlasO14495
HPRD06179
IPIIPI00021453   
Protein Interaction databases
DIP (DOE-UCLA)O14495
IntAct (EBI)O14495
FunCoupENSG00000162407
BioGRIDPLPP3
STRING (EMBL)PLPP3
ZODIACPLPP3
Ontologies - Pathways
QuickGOO14495
Ontology : AmiGOblood vessel development  gastrulation with mouth forming second  negative regulation of protein phosphorylation  phosphoprotein phosphatase activity  integrin binding  protein binding  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  integral component of plasma membrane  adherens junction  protein dephosphorylation  lipid metabolic process  phospholipid metabolic process  phosphatidate phosphatase activity  germ cell migration  membrane  regulation of Wnt signaling pathway  sphingolipid biosynthetic process  homotypic cell-cell adhesion  sphingosine-1-phosphate phosphatase activity  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration  canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion  canonical Wnt signaling pathway involved in positive regulation of wound healing  phospholipid dephosphorylation  positive regulation of peptidyl-tyrosine phosphorylation  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  Bergmann glial cell differentiation  extracellular exosome  regulation of sphingolipid mediated signaling pathway  
Ontology : EGO-EBIblood vessel development  gastrulation with mouth forming second  negative regulation of protein phosphorylation  phosphoprotein phosphatase activity  integrin binding  protein binding  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  integral component of plasma membrane  adherens junction  protein dephosphorylation  lipid metabolic process  phospholipid metabolic process  phosphatidate phosphatase activity  germ cell migration  membrane  regulation of Wnt signaling pathway  sphingolipid biosynthetic process  homotypic cell-cell adhesion  sphingosine-1-phosphate phosphatase activity  sphingosine-1-phosphate phosphatase activity  lipid phosphatase activity  canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration  canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion  canonical Wnt signaling pathway involved in positive regulation of wound healing  phospholipid dephosphorylation  positive regulation of peptidyl-tyrosine phosphorylation  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  Bergmann glial cell differentiation  extracellular exosome  regulation of sphingolipid mediated signaling pathway  
NDEx NetworkPLPP3
Atlas of Cancer Signalling NetworkPLPP3
Wikipedia pathwaysPLPP3
Orthology - Evolution
OrthoDB8613
GeneTree (enSembl)ENSG00000162407
Phylogenetic Trees/Animal Genes : TreeFamPLPP3
HOVERGENO14495
HOGENOMO14495
Homologs : HomoloGenePLPP3
Homology/Alignments : Family Browser (UCSC)PLPP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLPP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLPP3
dbVarPLPP3
ClinVarPLPP3
1000_GenomesPLPP3 
Exome Variant ServerPLPP3
ExAC (Exome Aggregation Consortium)PLPP3 (select the gene name)
Genetic variants : HAPMAP8613
Genomic Variants (DGV)PLPP3 [DGVbeta]
DECIPHER (Syndromes)1:56960419-57045257  ENSG00000162407
CONAN: Copy Number AnalysisPLPP3 
Mutations
ICGC Data PortalPLPP3 
TCGA Data PortalPLPP3 
Broad Tumor PortalPLPP3
OASIS PortalPLPP3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLPP3
BioMutasearch PLPP3
DgiDB (Drug Gene Interaction Database)PLPP3
DoCM (Curated mutations)PLPP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLPP3 (select a term)
intoGenPLPP3
Cancer3DPLPP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607125   
Orphanet
MedgenPLPP3
Genetic Testing Registry PLPP3
NextProtO14495 [Medical]
TSGene8613
GENETestsPLPP3
Huge Navigator PLPP3 [HugePedia]
snp3D : Map Gene to Disease8613
BioCentury BCIQPLPP3
ClinGenPLPP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8613
Chemical/Pharm GKB GenePA33553
Clinical trialPLPP3
Miscellaneous
canSAR (ICR)PLPP3 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLPP3
EVEXPLPP3
GoPubMedPLPP3
iHOPPLPP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:14:45 CEST 2017

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