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PLPP4 (phospholipid phosphatase 4)

Identity

Alias_namesPPAPDC1
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1
phosphatidic acid phosphatase type 2 domain containing 1A
Alias_symbol (synonym)DPPL2
Other alias
HGNC (Hugo) PLPP4
LocusID (NCBI) 196051
Atlas_Id 77949
Location 10q26.12  [Link to chromosome band 10q26]
Location_base_pair Starts at 120456954 and ends at 120589864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C10orf88 (10q26.13) / PLPP4 (10q26.12)DOCK1 (10q26.2) / PLPP4 (10q26.12)MOB1B (4q13.3) / PLPP4 (10q26.12)
PLPP4 (10q26.12) / C10orf82 (10q25.3)PLPP4 (10q26.12) / CXCR1 (2q35)PVT1 (8q24.21) / PLPP4 (10q26.12)
RAPGEF5 (7p15.3) / PLPP4 (10q26.12)SREBF2 (22q13.2) / PLPP4 (10q26.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLPP4   23531
Cards
Entrez_Gene (NCBI)PLPP4  196051  phospholipid phosphatase 4
AliasesDPPL2; PPAPDC1; PPAPDC1A
GeneCards (Weizmann)PLPP4
Ensembl hg19 (Hinxton)ENSG00000203805 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203805 [Gene_View]  chr10:120456954-120589864 [Contig_View]  PLPP4 [Vega]
ICGC DataPortalENSG00000203805
TCGA cBioPortalPLPP4
AceView (NCBI)PLPP4
Genatlas (Paris)PLPP4
WikiGenes196051
SOURCE (Princeton)PLPP4
Genetics Home Reference (NIH)PLPP4
Genomic and cartography
GoldenPath hg38 (UCSC)PLPP4  -     chr10:120456954-120589864 +  10q26.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLPP4  -     10q26.12   [Description]    (hg19-Feb_2009)
EnsemblPLPP4 - 10q26.12 [CytoView hg19]  PLPP4 - 10q26.12 [CytoView hg38]
Mapping of homologs : NCBIPLPP4 [Mapview hg19]  PLPP4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK098668 AK296273 AK310178 BC101267 BC101268
RefSeq transcript (Entrez)NM_001030059 NM_001318166 NM_001318167 NM_001318168 NM_001318169
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLPP4
Cluster EST : UnigeneHs.40479 [ NCBI ]
CGAP (NCI)Hs.40479
Alternative Splicing GalleryENSG00000203805
Gene ExpressionPLPP4 [ NCBI-GEO ]   PLPP4 [ EBI - ARRAY_EXPRESS ]   PLPP4 [ SEEK ]   PLPP4 [ MEM ]
Gene Expression Viewer (FireBrowse)PLPP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)196051
GTEX Portal (Tissue expression)PLPP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VZY2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VZY2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VZY2
Splice isoforms : SwissVarQ5VZY2
Catalytic activity : Enzyme3.1.3.4 [ Enzyme-Expasy ]   3.1.3.43.1.3.4 [ IntEnz-EBI ]   3.1.3.4 [ BRENDA ]   3.1.3.4 [ KEGG ]   
PhosPhoSitePlusQ5VZY2
Domains : Interpro (EBI)P_Acid_Pase_2/haloperoxidase    PLPP4   
Domain families : Pfam (Sanger)PAP2 (PF01569)   
Domain families : Pfam (NCBI)pfam01569   
Domain families : Smart (EMBL)acidPPc (SM00014)  
Conserved Domain (NCBI)PLPP4
DMDM Disease mutations196051
Blocks (Seattle)PLPP4
SuperfamilyQ5VZY2
Human Protein AtlasENSG00000203805
Peptide AtlasQ5VZY2
HPRD18745
IPIIPI00151444   IPI00845503   IPI00845417   IPI00922450   IPI00646785   
Protein Interaction databases
DIP (DOE-UCLA)Q5VZY2
IntAct (EBI)Q5VZY2
FunCoupENSG00000203805
BioGRIDPLPP4
STRING (EMBL)PLPP4
ZODIACPLPP4
Ontologies - Pathways
QuickGOQ5VZY2
Ontology : AmiGOplasma membrane  integral component of plasma membrane  phospholipid metabolic process  signal transduction  phosphatidate phosphatase activity  phosphatidate phosphatase activity  Fc-gamma receptor signaling pathway involved in phagocytosis  identical protein binding  phospholipid dephosphorylation  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  phospholipid metabolic process  signal transduction  phosphatidate phosphatase activity  phosphatidate phosphatase activity  Fc-gamma receptor signaling pathway involved in phagocytosis  identical protein binding  phospholipid dephosphorylation  
NDEx NetworkPLPP4
Atlas of Cancer Signalling NetworkPLPP4
Wikipedia pathwaysPLPP4
Orthology - Evolution
OrthoDB196051
GeneTree (enSembl)ENSG00000203805
Phylogenetic Trees/Animal Genes : TreeFamPLPP4
HOVERGENQ5VZY2
HOGENOMQ5VZY2
Homologs : HomoloGenePLPP4
Homology/Alignments : Family Browser (UCSC)PLPP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLPP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLPP4
dbVarPLPP4
ClinVarPLPP4
1000_GenomesPLPP4 
Exome Variant ServerPLPP4
ExAC (Exome Aggregation Consortium)PLPP4 (select the gene name)
Genetic variants : HAPMAP196051
Genomic Variants (DGV)PLPP4 [DGVbeta]
DECIPHERPLPP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLPP4 
Mutations
ICGC Data PortalPLPP4 
TCGA Data PortalPLPP4 
Broad Tumor PortalPLPP4
OASIS PortalPLPP4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPLPP4
BioMutasearch PLPP4
DgiDB (Drug Gene Interaction Database)PLPP4
DoCM (Curated mutations)PLPP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLPP4 (select a term)
intoGenPLPP4
Cancer3DPLPP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPLPP4
Genetic Testing Registry PLPP4
NextProtQ5VZY2 [Medical]
TSGene196051
GENETestsPLPP4
Target ValidationPLPP4
Huge Navigator PLPP4 [HugePedia]
snp3D : Map Gene to Disease196051
BioCentury BCIQPLPP4
ClinGenPLPP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD196051
Chemical/Pharm GKB GenePA134907381
Clinical trialPLPP4
Miscellaneous
canSAR (ICR)PLPP4 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLPP4
EVEXPLPP4
GoPubMedPLPP4
iHOPPLPP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:34:47 CEST 2017

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