Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PLPP4 (phospholipid phosphatase 4)

Identity

Alias (NCBI)DPPL2
PPAPDC1
PPAPDC1A
HGNC (Hugo) PLPP4
HGNC Alias symbDPPL2
HGNC Alias namediacylglycerol pyrophosphate phosphatase-like 2
HGNC Previous namePPAPDC1
 PPAPDC1A
HGNC Previous namephosphatidic acid phosphatase type 2 domain containing 1
 phosphatidic acid phosphatase type 2 domain containing 1A
LocusID (NCBI) 196051
Atlas_Id 57566
Location 10q26.12  [Link to chromosome band 10q26]
Location_base_pair Starts at 120456954 and ends at 120589864 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C10orf88 (10q26.13) / PLPP4 (10q26.12)DOCK1 (10q26.2) / PLPP4 (10q26.12)MOB1B (4q13.3) / PLPP4 (10q26.12)
PLPP4 (10q26.12) / C10orf82 (10q25.3)PLPP4 (10q26.12) / CXCR1 (2q35)PVT1 (8q24.21) / PLPP4 (10q26.12)
RAPGEF5 (7p15.3) / PLPP4 (10q26.12)SREBF2 (22q13.2) / PLPP4 (10q26.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLPP4   23531
Cards
Entrez_Gene (NCBI)PLPP4    phospholipid phosphatase 4
AliasesDPPL2; PPAPDC1; PPAPDC1A
GeneCards (Weizmann)PLPP4
Ensembl hg19 (Hinxton)ENSG00000203805 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203805 [Gene_View]  ENSG00000203805 [Sequence]  chr10:120456954-120589864 [Contig_View]  PLPP4 [Vega]
ICGC DataPortalENSG00000203805
TCGA cBioPortalPLPP4
AceView (NCBI)PLPP4
Genatlas (Paris)PLPP4
SOURCE (Princeton)PLPP4
Genetics Home Reference (NIH)PLPP4
Genomic and cartography
GoldenPath hg38 (UCSC)PLPP4  -     chr10:120456954-120589864 +  10q26.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLPP4  -     10q26.12   [Description]    (hg19-Feb_2009)
GoldenPathPLPP4 - 10q26.12 [CytoView hg19]  PLPP4 - 10q26.12 [CytoView hg38]
ImmunoBaseENSG00000203805
Genome Data Viewer NCBIPLPP4 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK098668 AK296273 AK310178 BC101267 BC101268
RefSeq transcript (Entrez)NM_001030059 NM_001318166 NM_001318167 NM_001318168 NM_001318169
Consensus coding sequences : CCDS (NCBI)PLPP4
Gene ExpressionPLPP4 [ NCBI-GEO ]   PLPP4 [ EBI - ARRAY_EXPRESS ]   PLPP4 [ SEEK ]   PLPP4 [ MEM ]
Gene Expression Viewer (FireBrowse)PLPP4 [ Firebrowse - Broad ]
GenevisibleExpression of PLPP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)196051
GTEX Portal (Tissue expression)PLPP4
Human Protein AtlasENSG00000203805-PLPP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VZY2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VZY2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VZY2
PhosPhoSitePlusQ5VZY2
Domains : Interpro (EBI)P_Acid_Pase_2/haloperoxi_sf    P_Acid_Pase_2/haloperoxidase    PLPP    PLPP4/5   
Domain families : Pfam (Sanger)PAP2 (PF01569)   
Domain families : Pfam (NCBI)pfam01569   
Domain families : Smart (EMBL)acidPPc (SM00014)  
Conserved Domain (NCBI)PLPP4
SuperfamilyQ5VZY2
AlphaFold pdb e-kbQ5VZY2   
Human Protein Atlas [tissue]ENSG00000203805-PLPP4 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q5VZY2
IntAct (EBI)Q5VZY2
BioGRIDPLPP4
STRING (EMBL)PLPP4
ZODIACPLPP4
Ontologies - Pathways
QuickGOQ5VZY2
Ontology : AmiGOdiacylglycerol diphosphate phosphatase activity  blastocyst hatching  protein binding  plasma membrane  phospholipid metabolic process  phosphatidate phosphatase activity  phosphatidate phosphatase activity  integral component of membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  lipid phosphatase activity  identical protein binding  phospholipid dephosphorylation  phospholipid dephosphorylation  regulation of calcium ion import  
Ontology : EGO-EBIdiacylglycerol diphosphate phosphatase activity  blastocyst hatching  protein binding  plasma membrane  phospholipid metabolic process  phosphatidate phosphatase activity  phosphatidate phosphatase activity  integral component of membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  lipid phosphatase activity  identical protein binding  phospholipid dephosphorylation  phospholipid dephosphorylation  regulation of calcium ion import  
NDEx NetworkPLPP4
Atlas of Cancer Signalling NetworkPLPP4
Wikipedia pathwaysPLPP4
Orthology - Evolution
OrthoDB196051
GeneTree (enSembl)ENSG00000203805
Phylogenetic Trees/Animal Genes : TreeFamPLPP4
Homologs : HomoloGenePLPP4
Homology/Alignments : Family Browser (UCSC)PLPP4
Gene fusions - Rearrangements
Fusion : QuiverPLPP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLPP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLPP4
dbVarPLPP4
ClinVarPLPP4
MonarchPLPP4
1000_GenomesPLPP4 
Exome Variant ServerPLPP4
GNOMAD BrowserENSG00000203805
Varsome BrowserPLPP4
ACMGPLPP4 variants
VarityQ5VZY2
Genomic Variants (DGV)PLPP4 [DGVbeta]
DECIPHERPLPP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLPP4 
Mutations
ICGC Data PortalPLPP4 
TCGA Data PortalPLPP4 
Broad Tumor PortalPLPP4
OASIS PortalPLPP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLPP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLPP4
Mutations and Diseases : HGMDPLPP4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLPP4
DgiDB (Drug Gene Interaction Database)PLPP4
DoCM (Curated mutations)PLPP4
CIViC (Clinical Interpretations of Variants in Cancer)PLPP4
Cancer3DPLPP4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPLPP4
MedgenPLPP4
Genetic Testing Registry PLPP4
NextProtQ5VZY2 [Medical]
GENETestsPLPP4
Target ValidationPLPP4
Huge Navigator PLPP4 [HugePedia]
ClinGenPLPP4
Clinical trials, drugs, therapy
MyCancerGenomePLPP4
Protein Interactions : CTDPLPP4
Pharm GKB GenePA134907381
PharosQ5VZY2
Clinical trialPLPP4
Miscellaneous
canSAR (ICR)PLPP4
HarmonizomePLPP4
DataMed IndexPLPP4
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLPP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:25:46 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.