PLPP5 (phospholipid phosphatase 5)

2015-10-01  

Identity

HGNC
PLPP5
LOCATION
8p11.23
LOCUSID
84513
ALIAS
DPPL1,HTPAP,PPAPDC1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84513
MIM: 610626
HGNC: 25026
Ensembl: ENSG00000147535

Variants:

dbSNP: 84513
ClinVar: 84513
TCGA: ENSG00000147535
COSMIC: PLPP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147535ENST00000419686Q8NEB5
ENSG00000147535ENST00000422581Q8NEB5
ENSG00000147535ENST00000424479Q8NEB5
ENSG00000147535ENST00000424479A0A140VK38
ENSG00000147535ENST00000524616H0YCQ3
ENSG00000147535ENST00000529359Q8NEB5
ENSG00000147535ENST00000531109H0YDY2
ENSG00000147535ENST00000531823E9PNB1
ENSG00000147535ENST00000534339H0YCK0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485

References

Pubmed IDYearTitleCitations
187574322008Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.37
162611602006HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.10
240510132013PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.10
175905382007Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.6
215317642011Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma.4
212195412011Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma.2
246034122014Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.1

Citation

Dessen P

PLPP5 (phospholipid phosphatase 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55473/plpp5