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PLRG1 (pleiotropic regulator 1)

Identity

Alias (NCBI)Cwc1
PRL1
PRP46
PRPF46
TANGO4
HGNC (Hugo) PLRG1
HGNC Alias symbPRL1
Prp46
PRPF46
Cwc1
TANGO4
HGNC Alias nametransport and golgi organization 4 homolog (Drosophila)
HGNC Previous namepleiotropic regulator 1 (PRL1, Arabidopsis homolog)
 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
LocusID (NCBI) 5356
Atlas_Id 72004
Location 4q31.3  [Link to chromosome band 4q31]
Location_base_pair Starts at 154535005 and ends at 154550400 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX60L (4q32.3) / PLRG1 (4q31.3)SEC24D (4q26) / PLRG1 (4q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLRG1   9089
Cards
Entrez_Gene (NCBI)PLRG1    pleiotropic regulator 1
AliasesCwc1; PRL1; PRP46; PRPF46; 
TANGO4
GeneCards (Weizmann)PLRG1
Ensembl hg19 (Hinxton)ENSG00000171566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171566 [Gene_View]  ENSG00000171566 [Sequence]  chr4:154535005-154550400 [Contig_View]  PLRG1 [Vega]
ICGC DataPortalENSG00000171566
TCGA cBioPortalPLRG1
AceView (NCBI)PLRG1
Genatlas (Paris)PLRG1
SOURCE (Princeton)PLRG1
Genetics Home Reference (NIH)PLRG1
Genomic and cartography
GoldenPath hg38 (UCSC)PLRG1  -     chr4:154535005-154550400 -  4q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLRG1  -     4q31.3   [Description]    (hg19-Feb_2009)
GoldenPathPLRG1 - 4q31.3 [CytoView hg19]  PLRG1 - 4q31.3 [CytoView hg38]
ImmunoBaseENSG00000171566
Genome Data Viewer NCBIPLRG1 [Mapview hg19]  
OMIM605961   
Gene and transcription
Genbank (Entrez)AF044333 AK002108 AK304574 AK307997 AW291931
RefSeq transcript (Entrez)NM_001201564 NM_002669
Consensus coding sequences : CCDS (NCBI)PLRG1
Gene ExpressionPLRG1 [ NCBI-GEO ]   PLRG1 [ EBI - ARRAY_EXPRESS ]   PLRG1 [ SEEK ]   PLRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLRG1 [ Firebrowse - Broad ]
GenevisibleExpression of PLRG1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5356
GTEX Portal (Tissue expression)PLRG1
Human Protein AtlasENSG00000171566-PLRG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43660   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43660  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43660
PhosPhoSitePlusO43660
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PLRG1
PDB (RSDB)4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
PDB Europe4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
PDB (PDBSum)4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
PDB (IMB)4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
Structural Biology KnowledgeBase4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
SCOP (Structural Classification of Proteins)4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
CATH (Classification of proteins structures)4YVD    5MQF    5XJC    5YZG    5Z56    5Z57    5Z58    6FF4    6FF7    6ICZ    6ID0    6ID1    6QDV    6ZYM   
SuperfamilyO43660
AlphaFold pdb e-kbO43660   
Human Protein Atlas [tissue]ENSG00000171566-PLRG1 [tissue]
HPRD16181
Protein Interaction databases
DIP (DOE-UCLA)O43660
IntAct (EBI)O43660
BioGRIDPLRG1
STRING (EMBL)PLRG1
ZODIACPLRG1
Ontologies - Pathways
QuickGOO43660
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  fibrillar center  protein binding  nucleus  nucleoplasm  nuclear speck  nuclear membrane  protein localization to nucleus  U2-type catalytic step 2 spliceosome  catalytic step 2 spliceosome  catalytic step 2 spliceosome  Cul4-RING E3 ubiquitin ligase complex  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  fibrillar center  protein binding  nucleus  nucleoplasm  nuclear speck  nuclear membrane  protein localization to nucleus  U2-type catalytic step 2 spliceosome  catalytic step 2 spliceosome  catalytic step 2 spliceosome  Cul4-RING E3 ubiquitin ligase complex  positive regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkPLRG1
Atlas of Cancer Signalling NetworkPLRG1
Wikipedia pathwaysPLRG1
Orthology - Evolution
OrthoDB5356
GeneTree (enSembl)ENSG00000171566
Phylogenetic Trees/Animal Genes : TreeFamPLRG1
Homologs : HomoloGenePLRG1
Homology/Alignments : Family Browser (UCSC)PLRG1
Gene fusions - Rearrangements
Fusion : QuiverPLRG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLRG1
dbVarPLRG1
ClinVarPLRG1
MonarchPLRG1
1000_GenomesPLRG1 
Exome Variant ServerPLRG1
GNOMAD BrowserENSG00000171566
Varsome BrowserPLRG1
ACMGPLRG1 variants
VarityO43660
Genomic Variants (DGV)PLRG1 [DGVbeta]
DECIPHERPLRG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLRG1 
Mutations
ICGC Data PortalPLRG1 
TCGA Data PortalPLRG1 
Broad Tumor PortalPLRG1
OASIS PortalPLRG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLRG1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLRG1
Mutations and Diseases : HGMDPLRG1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLRG1
DgiDB (Drug Gene Interaction Database)PLRG1
DoCM (Curated mutations)PLRG1
CIViC (Clinical Interpretations of Variants in Cancer)PLRG1
Cancer3DPLRG1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605961   
Orphanet
DisGeNETPLRG1
MedgenPLRG1
Genetic Testing Registry PLRG1
NextProtO43660 [Medical]
GENETestsPLRG1
Target ValidationPLRG1
Huge Navigator PLRG1 [HugePedia]
ClinGenPLRG1
Clinical trials, drugs, therapy
MyCancerGenomePLRG1
Protein Interactions : CTDPLRG1
Pharm GKB GenePA33416
PharosO43660
Clinical trialPLRG1
Miscellaneous
canSAR (ICR)PLRG1
HarmonizomePLRG1
DataMed IndexPLRG1
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:16:33 CEST 2021

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