Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PLRG1 (pleiotropic regulator 1)

Identity

Alias_namespleiotropic regulator 1 (PRL1, Arabidopsis homolog)
pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
Alias_symbol (synonym)PRL1
Prp46
PRPF46
Cwc1
TANGO4
Other aliasPRP46
HGNC (Hugo) PLRG1
LocusID (NCBI) 5356
Atlas_Id 72004
Location 4q31.3  [Link to chromosome band 4q31]
Location_base_pair Starts at 154534997 and ends at 154550433 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DDX60L (4q32.3) / PLRG1 (4q31.3)SEC24D (4q26) / PLRG1 (4q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLRG1   9089
Cards
Entrez_Gene (NCBI)PLRG1  5356  pleiotropic regulator 1
AliasesCwc1; PRL1; PRP46; PRPF46; 
TANGO4
GeneCards (Weizmann)PLRG1
Ensembl hg19 (Hinxton)ENSG00000171566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171566 [Gene_View]  chr4:154534997-154550433 [Contig_View]  PLRG1 [Vega]
ICGC DataPortalENSG00000171566
TCGA cBioPortalPLRG1
AceView (NCBI)PLRG1
Genatlas (Paris)PLRG1
WikiGenes5356
SOURCE (Princeton)PLRG1
Genetics Home Reference (NIH)PLRG1
Genomic and cartography
GoldenPath hg38 (UCSC)PLRG1  -     chr4:154534997-154550433 -  4q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLRG1  -     4q31.3   [Description]    (hg19-Feb_2009)
EnsemblPLRG1 - 4q31.3 [CytoView hg19]  PLRG1 - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBIPLRG1 [Mapview hg19]  PLRG1 [Mapview hg38]
OMIM605961   
Gene and transcription
Genbank (Entrez)AF044333 AK002108 AK304574 AK307997 AW291931
RefSeq transcript (Entrez)NM_001201564 NM_002669
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLRG1
Cluster EST : UnigeneHs.249996 [ NCBI ]
CGAP (NCI)Hs.249996
Alternative Splicing GalleryENSG00000171566
Gene ExpressionPLRG1 [ NCBI-GEO ]   PLRG1 [ EBI - ARRAY_EXPRESS ]   PLRG1 [ SEEK ]   PLRG1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLRG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5356
GTEX Portal (Tissue expression)PLRG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43660   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43660  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43660
Splice isoforms : SwissVarO43660
PhosPhoSitePlusO43660
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PLRG1
DMDM Disease mutations5356
Blocks (Seattle)PLRG1
PDB (SRS)4YVD   
PDB (PDBSum)4YVD   
PDB (IMB)4YVD   
PDB (RSDB)4YVD   
Structural Biology KnowledgeBase4YVD   
SCOP (Structural Classification of Proteins)4YVD   
CATH (Classification of proteins structures)4YVD   
SuperfamilyO43660
Human Protein AtlasENSG00000171566
Peptide AtlasO43660
HPRD16181
IPIIPI00002624   IPI00382756   IPI00871903   IPI00966966   IPI00921981   IPI00968135   IPI00966646   IPI00965708   IPI00967852   
Protein Interaction databases
DIP (DOE-UCLA)O43660
IntAct (EBI)O43660
FunCoupENSG00000171566
BioGRIDPLRG1
STRING (EMBL)PLRG1
ZODIACPLRG1
Ontologies - Pathways
QuickGOO43660
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  fibrillar center  protein binding  nucleoplasm  DNA replication factor A complex  nuclear speck  nuclear membrane  protein localization to nucleus  precatalytic spliceosome  catalytic step 2 spliceosome  Cul4-RING E3 ubiquitin ligase complex  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  fibrillar center  protein binding  nucleoplasm  DNA replication factor A complex  nuclear speck  nuclear membrane  protein localization to nucleus  precatalytic spliceosome  catalytic step 2 spliceosome  Cul4-RING E3 ubiquitin ligase complex  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGSpliceosome   
NDEx NetworkPLRG1
Atlas of Cancer Signalling NetworkPLRG1
Wikipedia pathwaysPLRG1
Orthology - Evolution
OrthoDB5356
GeneTree (enSembl)ENSG00000171566
Phylogenetic Trees/Animal Genes : TreeFamPLRG1
HOVERGENO43660
HOGENOMO43660
Homologs : HomoloGenePLRG1
Homology/Alignments : Family Browser (UCSC)PLRG1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLRG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLRG1
dbVarPLRG1
ClinVarPLRG1
1000_GenomesPLRG1 
Exome Variant ServerPLRG1
ExAC (Exome Aggregation Consortium)PLRG1 (select the gene name)
Genetic variants : HAPMAP5356
Genomic Variants (DGV)PLRG1 [DGVbeta]
DECIPHERPLRG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLRG1 
Mutations
ICGC Data PortalPLRG1 
TCGA Data PortalPLRG1 
Broad Tumor PortalPLRG1
OASIS PortalPLRG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLRG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLRG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLRG1
DgiDB (Drug Gene Interaction Database)PLRG1
DoCM (Curated mutations)PLRG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLRG1 (select a term)
intoGenPLRG1
Cancer3DPLRG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605961   
Orphanet
MedgenPLRG1
Genetic Testing Registry PLRG1
NextProtO43660 [Medical]
TSGene5356
GENETestsPLRG1
Target ValidationPLRG1
Huge Navigator PLRG1 [HugePedia]
snp3D : Map Gene to Disease5356
BioCentury BCIQPLRG1
ClinGenPLRG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5356
Chemical/Pharm GKB GenePA33416
Clinical trialPLRG1
Miscellaneous
canSAR (ICR)PLRG1 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLRG1
EVEXPLRG1
GoPubMedPLRG1
iHOPPLRG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:34:48 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.