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PLS1 (plastin 1)

Identity

Alias_namesplastin 1 (I isoform)
Alias_symbol (synonym)I-plastin
Plastin-1
Other alias-
HGNC (Hugo) PLS1
LocusID (NCBI) 5357
Atlas_Id 41750
Location 3q23  [Link to chromosome band 3q23]
Location_base_pair Starts at 142596387 and ends at 142713663 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLS1 (3q23) / CLDN18 (3q22.3)PLS1 (3q23) / TFDP2 (3q23)PLS1 3q23 / CLDN18 3q22.3
PLS1 3q23 / TFDP2 3q23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLS1   9090
Cards
Entrez_Gene (NCBI)PLS1  5357  plastin 1
Aliases
GeneCards (Weizmann)PLS1
Ensembl hg19 (Hinxton)ENSG00000120756 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120756 [Gene_View]  chr3:142596387-142713663 [Contig_View]  PLS1 [Vega]
ICGC DataPortalENSG00000120756
TCGA cBioPortalPLS1
AceView (NCBI)PLS1
Genatlas (Paris)PLS1
WikiGenes5357
SOURCE (Princeton)PLS1
Genetics Home Reference (NIH)PLS1
Genomic and cartography
GoldenPath hg38 (UCSC)PLS1  -     chr3:142596387-142713663 +  3q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLS1  -     3q23   [Description]    (hg19-Feb_2009)
EnsemblPLS1 - 3q23 [CytoView hg19]  PLS1 - 3q23 [CytoView hg38]
Mapping of homologs : NCBIPLS1 [Mapview hg19]  PLS1 [Mapview hg38]
OMIM602734   
Gene and transcription
Genbank (Entrez)AA933088 AK290316 BC031083 BM263745 BP262012
RefSeq transcript (Entrez)NM_001145319 NM_001172312 NM_002670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLS1
Cluster EST : UnigeneHs.203637 [ NCBI ]
CGAP (NCI)Hs.203637
Alternative Splicing GalleryENSG00000120756
Gene ExpressionPLS1 [ NCBI-GEO ]   PLS1 [ EBI - ARRAY_EXPRESS ]   PLS1 [ SEEK ]   PLS1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5357
GTEX Portal (Tissue expression)PLS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14651   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14651  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14651
Splice isoforms : SwissVarQ14651
PhosPhoSitePlusQ14651
Domaine pattern : Prosite (Expaxy)ACTININ_1 (PS00019)    ACTININ_2 (PS00020)    CH (PS50021)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)Actinin_actin-bd_CS    CH-domain    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    PLS1   
Domain families : Pfam (Sanger)CH (PF00307)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam00307    pfam13499   
Domain families : Smart (EMBL)CH (SM00033)  EFh (SM00054)  
Conserved Domain (NCBI)PLS1
DMDM Disease mutations5357
Blocks (Seattle)PLS1
SuperfamilyQ14651
Human Protein AtlasENSG00000120756
Peptide AtlasQ14651
HPRD04110
IPIIPI00032304   IPI00947316   IPI00947477   IPI00945649   IPI00947055   IPI00789401   IPI00946087   IPI00945930   
Protein Interaction databases
DIP (DOE-UCLA)Q14651
IntAct (EBI)Q14651
FunCoupENSG00000120756
BioGRIDPLS1
STRING (EMBL)PLS1
ZODIACPLS1
Ontologies - Pathways
QuickGOQ14651
Ontology : AmiGOintestinal D-glucose absorption  structural constituent of cytoskeleton  calcium ion binding  cytoplasm  actin filament  brush border  actin filament bundle  regulation of microvillus length  positive regulation of multicellular organism growth  actin filament binding  actin filament bundle assembly  actin filament network formation  actin crosslink formation  extracellular exosome  positive regulation of establishment of protein localization to plasma membrane  terminal web assembly  terminal web  
Ontology : EGO-EBIintestinal D-glucose absorption  structural constituent of cytoskeleton  calcium ion binding  cytoplasm  actin filament  brush border  actin filament bundle  regulation of microvillus length  positive regulation of multicellular organism growth  actin filament binding  actin filament bundle assembly  actin filament network formation  actin crosslink formation  extracellular exosome  positive regulation of establishment of protein localization to plasma membrane  terminal web assembly  terminal web  
NDEx NetworkPLS1
Atlas of Cancer Signalling NetworkPLS1
Wikipedia pathwaysPLS1
Orthology - Evolution
OrthoDB5357
GeneTree (enSembl)ENSG00000120756
Phylogenetic Trees/Animal Genes : TreeFamPLS1
HOVERGENQ14651
HOGENOMQ14651
Homologs : HomoloGenePLS1
Homology/Alignments : Family Browser (UCSC)PLS1
Gene fusions - Rearrangements
Fusion : MitelmanPLS1/CLDN18 [3q23/3q22.3]  
Fusion: TCGAPLS1 3q23 CLDN18 3q22.3 BRCA
Fusion: TCGAPLS1 3q23 TFDP2 3q23 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLS1
dbVarPLS1
ClinVarPLS1
1000_GenomesPLS1 
Exome Variant ServerPLS1
ExAC (Exome Aggregation Consortium)PLS1 (select the gene name)
Genetic variants : HAPMAP5357
Genomic Variants (DGV)PLS1 [DGVbeta]
DECIPHERPLS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLS1 
Mutations
ICGC Data PortalPLS1 
TCGA Data PortalPLS1 
Broad Tumor PortalPLS1
OASIS PortalPLS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLS1
DgiDB (Drug Gene Interaction Database)PLS1
DoCM (Curated mutations)PLS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLS1 (select a term)
intoGenPLS1
Cancer3DPLS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602734   
Orphanet
MedgenPLS1
Genetic Testing Registry PLS1
NextProtQ14651 [Medical]
TSGene5357
GENETestsPLS1
Target ValidationPLS1
Huge Navigator PLS1 [HugePedia]
snp3D : Map Gene to Disease5357
BioCentury BCIQPLS1
ClinGenPLS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5357
Chemical/Pharm GKB GenePA33417
Clinical trialPLS1
Miscellaneous
canSAR (ICR)PLS1 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLS1
EVEXPLS1
GoPubMedPLS1
iHOPPLS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:19 CEST 2017

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