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PLS3 (plastin 3)

Identity

Alias_namesplastin 3 (T isoform)
Alias_symbol (synonym)T-plastin
Other aliasBMND18
HGNC (Hugo) PLS3
LocusID (NCBI) 5358
Atlas_Id 50542
Location Xq23  [Link to chromosome band Xq23]
Location_base_pair Starts at 115593507 and ends at 115650859 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAR (1q21.3) / PLS3 (Xq23)PLS3 (Xq23) / CCDC64 (12q24.23)PLS3 (Xq23) / HSPH1 (13q12.3)
PLS3 Xq23 / CCDC64 12q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLS3   9091
Cards
Entrez_Gene (NCBI)PLS3  5358  plastin 3
AliasesBMND18; T-plastin
GeneCards (Weizmann)PLS3
Ensembl hg19 (Hinxton)ENSG00000102024 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102024 [Gene_View]  chrX:115593507-115650859 [Contig_View]  PLS3 [Vega]
ICGC DataPortalENSG00000102024
TCGA cBioPortalPLS3
AceView (NCBI)PLS3
Genatlas (Paris)PLS3
WikiGenes5358
SOURCE (Princeton)PLS3
Genetics Home Reference (NIH)PLS3
Genomic and cartography
GoldenPath hg38 (UCSC)PLS3  -     chrX:115593507-115650859 +  Xq23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLS3  -     Xq23   [Description]    (hg19-Feb_2009)
EnsemblPLS3 - Xq23 [CytoView hg19]  PLS3 - Xq23 [CytoView hg38]
Mapping of homologs : NCBIPLS3 [Mapview hg19]  PLS3 [Mapview hg38]
OMIM300131   300910   
Gene and transcription
Genbank (Entrez)AA704125 AK222801 AK294385 AK294509 AK295429
RefSeq transcript (Entrez)NM_001136025 NM_001172335 NM_001282337 NM_001282338 NM_005032
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLS3
Cluster EST : UnigeneHs.496622 [ NCBI ]
CGAP (NCI)Hs.496622
Alternative Splicing GalleryENSG00000102024
Gene ExpressionPLS3 [ NCBI-GEO ]   PLS3 [ EBI - ARRAY_EXPRESS ]   PLS3 [ SEEK ]   PLS3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5358
GTEX Portal (Tissue expression)PLS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13797   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13797  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13797
Splice isoforms : SwissVarP13797
PhosPhoSitePlusP13797
Domaine pattern : Prosite (Expaxy)ACTININ_1 (PS00019)    ACTININ_2 (PS00020)    CH (PS50021)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)Actinin_actin-bd_CS    CH-domain    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)CH (PF00307)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam00307    pfam13499   
Domain families : Smart (EMBL)CH (SM00033)  EFh (SM00054)  
Conserved Domain (NCBI)PLS3
DMDM Disease mutations5358
Blocks (Seattle)PLS3
PDB (SRS)1AOA    1WJO   
PDB (PDBSum)1AOA    1WJO   
PDB (IMB)1AOA    1WJO   
PDB (RSDB)1AOA    1WJO   
Structural Biology KnowledgeBase1AOA    1WJO   
SCOP (Structural Classification of Proteins)1AOA    1WJO   
CATH (Classification of proteins structures)1AOA    1WJO   
SuperfamilyP13797
Human Protein AtlasENSG00000102024
Peptide AtlasP13797
HPRD02133
IPIIPI00216694   IPI01011191   IPI01015144   IPI00908503   IPI00947227   IPI00947292   IPI00947454   
Protein Interaction databases
DIP (DOE-UCLA)P13797
IntAct (EBI)P13797
FunCoupENSG00000102024
BioGRIDPLS3
STRING (EMBL)PLS3
ZODIACPLS3
Ontologies - Pathways
QuickGOP13797
Ontology : AmiGOcalcium ion binding  cytoplasm  cytosol  actin filament  plasma membrane  actin filament bundle  actin filament binding  actin filament bundle assembly  actin filament network formation  actin crosslink formation  bone development  
Ontology : EGO-EBIcalcium ion binding  cytoplasm  cytosol  actin filament  plasma membrane  actin filament bundle  actin filament binding  actin filament bundle assembly  actin filament network formation  actin crosslink formation  bone development  
NDEx NetworkPLS3
Atlas of Cancer Signalling NetworkPLS3
Wikipedia pathwaysPLS3
Orthology - Evolution
OrthoDB5358
GeneTree (enSembl)ENSG00000102024
Phylogenetic Trees/Animal Genes : TreeFamPLS3
HOVERGENP13797
HOGENOMP13797
Homologs : HomoloGenePLS3
Homology/Alignments : Family Browser (UCSC)PLS3
Gene fusions - Rearrangements
Fusion : MitelmanPLS3/CCDC64 [Xq23/12q24.23]  
Fusion: TCGAPLS3 Xq23 CCDC64 12q24.23 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLS3
dbVarPLS3
ClinVarPLS3
1000_GenomesPLS3 
Exome Variant ServerPLS3
ExAC (Exome Aggregation Consortium)PLS3 (select the gene name)
Genetic variants : HAPMAP5358
Genomic Variants (DGV)PLS3 [DGVbeta]
DECIPHERPLS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLS3 
Mutations
ICGC Data PortalPLS3 
TCGA Data PortalPLS3 
Broad Tumor PortalPLS3
OASIS PortalPLS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)Osteogenesis Imperfecta Variant Database
BioMutasearch PLS3
DgiDB (Drug Gene Interaction Database)PLS3
DoCM (Curated mutations)PLS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLS3 (select a term)
intoGenPLS3
Cancer3DPLS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300131    300910   
Orphanet22606   
MedgenPLS3
Genetic Testing Registry PLS3
NextProtP13797 [Medical]
TSGene5358
GENETestsPLS3
Target ValidationPLS3
Huge Navigator PLS3 [HugePedia]
snp3D : Map Gene to Disease5358
BioCentury BCIQPLS3
ClinGenPLS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5358
Chemical/Pharm GKB GenePA33418
Clinical trialPLS3
Miscellaneous
canSAR (ICR)PLS3 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLS3
EVEXPLS3
GoPubMedPLS3
iHOPPLS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:19 CEST 2017

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