Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLXDC1 (plexin domain containing 1)

Identity

Alias_symbol (synonym)TEM3
TEM7
Other alias
HGNC (Hugo) PLXDC1
LocusID (NCBI) 57125
Atlas_Id 41752
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39063303 and ends at 39151649 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAB2 (11q14.1) / PLXDC1 (17q12)GRB7 (17q12) / PLXDC1 (17q12)PHF12 (17q11.2) / PLXDC1 (17q12)
GAB2 11q14.1 / PLXDC1 17q12GRB7 17q12 / PLXDC1 17q12PHF12 17q11.2 / PLXDC1 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXDC1   20945
Cards
Entrez_Gene (NCBI)PLXDC1  57125  plexin domain containing 1
AliasesTEM3; TEM7
GeneCards (Weizmann)PLXDC1
Ensembl hg19 (Hinxton)ENSG00000161381 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161381 [Gene_View]  chr17:39063303-39151649 [Contig_View]  PLXDC1 [Vega]
ICGC DataPortalENSG00000161381
TCGA cBioPortalPLXDC1
AceView (NCBI)PLXDC1
Genatlas (Paris)PLXDC1
WikiGenes57125
SOURCE (Princeton)PLXDC1
Genetics Home Reference (NIH)PLXDC1
Genomic and cartography
GoldenPath hg38 (UCSC)PLXDC1  -     chr17:39063303-39151649 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXDC1  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblPLXDC1 - 17q12 [CytoView hg19]  PLXDC1 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIPLXDC1 [Mapview hg19]  PLXDC1 [Mapview hg38]
OMIM606826   
Gene and transcription
Genbank (Entrez)AF070526 AF279144 AF378753 AK093589 AK127539
RefSeq transcript (Entrez)NM_020405
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLXDC1
Cluster EST : UnigeneHs.125036 [ NCBI ]
CGAP (NCI)Hs.125036
Alternative Splicing GalleryENSG00000161381
Gene ExpressionPLXDC1 [ NCBI-GEO ]   PLXDC1 [ EBI - ARRAY_EXPRESS ]   PLXDC1 [ SEEK ]   PLXDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXDC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57125
GTEX Portal (Tissue expression)PLXDC1
Human Protein AtlasENSG00000161381-PLXDC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUK5
Splice isoforms : SwissVarQ8IUK5
PhosPhoSitePlusQ8IUK5
Domains : Interpro (EBI)Plexin_repeat    PLXDC    PLXDC1   
Domain families : Pfam (Sanger)PSI (PF01437)   
Domain families : Pfam (NCBI)pfam01437   
Conserved Domain (NCBI)PLXDC1
DMDM Disease mutations57125
Blocks (Seattle)PLXDC1
SuperfamilyQ8IUK5
Human Protein Atlas [tissue]ENSG00000161381-PLXDC1 [tissue]
Peptide AtlasQ8IUK5
HPRD08439
IPIIPI00410122   IPI00743008   IPI00748865   IPI00745693   IPI01011944   IPI00909638   IPI00444379   IPI00790128   IPI00789458   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUK5
IntAct (EBI)Q8IUK5
FunCoupENSG00000161381
BioGRIDPLXDC1
STRING (EMBL)PLXDC1
ZODIACPLXDC1
Ontologies - Pathways
QuickGOQ8IUK5
Ontology : AmiGOangiogenesis  protein binding  extracellular region  cytoplasm  plasma membrane  bicellular tight junction  integral component of membrane  spinal cord development  dendrite  neuronal cell body  receptor complex  
Ontology : EGO-EBIangiogenesis  protein binding  extracellular region  cytoplasm  plasma membrane  bicellular tight junction  integral component of membrane  spinal cord development  dendrite  neuronal cell body  receptor complex  
NDEx NetworkPLXDC1
Atlas of Cancer Signalling NetworkPLXDC1
Wikipedia pathwaysPLXDC1
Orthology - Evolution
OrthoDB57125
GeneTree (enSembl)ENSG00000161381
Phylogenetic Trees/Animal Genes : TreeFamPLXDC1
HOVERGENQ8IUK5
HOGENOMQ8IUK5
Homologs : HomoloGenePLXDC1
Homology/Alignments : Family Browser (UCSC)PLXDC1
Gene fusions - Rearrangements
Fusion : MitelmanGAB2/PLXDC1 [11q14.1/17q12]  [t(11;17)(q14;q12)]  
Fusion : MitelmanPHF12/PLXDC1 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion: TCGA_MDACCGAB2 11q14.1 PLXDC1 17q12 BRCA
Fusion: TCGA_MDACCGRB7 17q12 PLXDC1 17q12 BLCA
Fusion: TCGA_MDACCPHF12 17q11.2 PLXDC1 17q12 LUAD
Tumor Fusion PortalPLXDC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXDC1
dbVarPLXDC1
ClinVarPLXDC1
1000_GenomesPLXDC1 
Exome Variant ServerPLXDC1
ExAC (Exome Aggregation Consortium)ENSG00000161381
GNOMAD BrowserENSG00000161381
Genetic variants : HAPMAP57125
Genomic Variants (DGV)PLXDC1 [DGVbeta]
DECIPHERPLXDC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXDC1 
Mutations
ICGC Data PortalPLXDC1 
TCGA Data PortalPLXDC1 
Broad Tumor PortalPLXDC1
OASIS PortalPLXDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXDC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXDC1
DgiDB (Drug Gene Interaction Database)PLXDC1
DoCM (Curated mutations)PLXDC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXDC1 (select a term)
intoGenPLXDC1
Cancer3DPLXDC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606826   
Orphanet
DisGeNETPLXDC1
MedgenPLXDC1
Genetic Testing Registry PLXDC1
NextProtQ8IUK5 [Medical]
TSGene57125
GENETestsPLXDC1
Target ValidationPLXDC1
Huge Navigator PLXDC1 [HugePedia]
snp3D : Map Gene to Disease57125
BioCentury BCIQPLXDC1
ClinGenPLXDC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57125
Chemical/Pharm GKB GenePA134990658
Clinical trialPLXDC1
Miscellaneous
canSAR (ICR)PLXDC1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXDC1
EVEXPLXDC1
GoPubMedPLXDC1
iHOPPLXDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:29:15 CET 2017

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