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PLXDC2 (plexin domain containing 2)

Identity

Alias (NCBI)TEM7R
HGNC (Hugo) PLXDC2
HGNC Alias symbTEM7R
FLJ14623
HGNC Alias nametumor endothelial marker 7-related precursor
LocusID (NCBI) 84898
Atlas_Id 41753
Location 10p12.31  [Link to chromosome band 10p12]
Location_base_pair Starts at 19816432 and ends at 20289855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN1C (11p15.4) / PLXDC2 (10p12.31)MPHOSPH6 (16q23.3) / PLXDC2 (10p12.31)PLXDC2 (10p12.31) / MALRD1 (10p12.31)
PLXDC2 (10p12.31) / PLXDC2 (10p12.31)PLXDC2 (10p12.31) / ST8SIA6 (10p12.33)PLXDC2 (10p12.31) / SYNE1 (6q25.1)
PLXDC2 (10p12.31) / VAMP5 (2p11.2)SPAG6 (10p12.2) / PLXDC2 (10p12.31)MPHOSPH6 16q23.3 / PLXDC2 10p12.31
PLXDC2 10p12.31 C10orf112PLXDC2 10p12.31 / ST8SIA6 10p12.33PLXDC2 10p12.31 / SYNE1 6q25.1
PLXDC2 10p12.31 / VAMP5 2p11.2SPAG6 10p12.2 / PLXDC2 10p12.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLXDC2   21013
Cards
Entrez_Gene (NCBI)PLXDC2    plexin domain containing 2
AliasesTEM7R
GeneCards (Weizmann)PLXDC2
Ensembl hg19 (Hinxton)ENSG00000120594 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120594 [Gene_View]  ENSG00000120594 [Sequence]  chr10:19816432-20289855 [Contig_View]  PLXDC2 [Vega]
ICGC DataPortalENSG00000120594
TCGA cBioPortalPLXDC2
AceView (NCBI)PLXDC2
Genatlas (Paris)PLXDC2
SOURCE (Princeton)PLXDC2
Genetics Home Reference (NIH)PLXDC2
Genomic and cartography
GoldenPath hg38 (UCSC)PLXDC2  -     chr10:19816432-20289855 +  10p12.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXDC2  -     10p12.31   [Description]    (hg19-Feb_2009)
GoldenPathPLXDC2 - 10p12.31 [CytoView hg19]  PLXDC2 - 10p12.31 [CytoView hg38]
ImmunoBaseENSG00000120594
Genome Data Viewer NCBIPLXDC2 [Mapview hg19]  
OMIM606827   
Gene and transcription
Genbank (Entrez)AF378757 AI311457 AK027529 AK127644 AK304591
RefSeq transcript (Entrez)NM_001282736 NM_032812
Consensus coding sequences : CCDS (NCBI)PLXDC2
Gene ExpressionPLXDC2 [ NCBI-GEO ]   PLXDC2 [ EBI - ARRAY_EXPRESS ]   PLXDC2 [ SEEK ]   PLXDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXDC2 [ Firebrowse - Broad ]
GenevisibleExpression of PLXDC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84898
GTEX Portal (Tissue expression)PLXDC2
Human Protein AtlasENSG00000120594-PLXDC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UX71   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UX71  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UX71
PhosPhoSitePlusQ6UX71
Domains : Interpro (EBI)Plexin_repeat    PLXDC    PLXDC2    PSI   
Domain families : Pfam (Sanger)PSI (PF01437)   
Domain families : Pfam (NCBI)pfam01437   
Domain families : Smart (EMBL)PSI (SM00423)  
Conserved Domain (NCBI)PLXDC2
SuperfamilyQ6UX71
AlphaFold pdb e-kbQ6UX71   
Human Protein Atlas [tissue]ENSG00000120594-PLXDC2 [tissue]
HPRD08440
Protein Interaction databases
DIP (DOE-UCLA)Q6UX71
IntAct (EBI)Q6UX71
BioGRIDPLXDC2
STRING (EMBL)PLXDC2
ZODIACPLXDC2
Ontologies - Pathways
QuickGOQ6UX71
Ontology : AmiGOprotein binding  integral component of membrane  
Ontology : EGO-EBIprotein binding  integral component of membrane  
NDEx NetworkPLXDC2
Atlas of Cancer Signalling NetworkPLXDC2
Wikipedia pathwaysPLXDC2
Orthology - Evolution
OrthoDB84898
GeneTree (enSembl)ENSG00000120594
Phylogenetic Trees/Animal Genes : TreeFamPLXDC2
Homologs : HomoloGenePLXDC2
Homology/Alignments : Family Browser (UCSC)PLXDC2
Gene fusions - Rearrangements
Fusion : MitelmanMPHOSPH6/PLXDC2 [16q23.3/10p12.31]  
Fusion : MitelmanPLXDC2/MALRD1 [10p12.31/10p12.31]  
Fusion : MitelmanPLXDC2/ST8SIA6 [10p12.31/10p12.33]  
Fusion : MitelmanPLXDC2/SYNE1 [10p12.31/6q25.1]  
Fusion : MitelmanPLXDC2/VAMP5 [10p12.31/2p11.2]  
Fusion : MitelmanSPAG6/PLXDC2 [10p12.2/10p12.31]  
Fusion : QuiverPLXDC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXDC2
dbVarPLXDC2
ClinVarPLXDC2
MonarchPLXDC2
1000_GenomesPLXDC2 
Exome Variant ServerPLXDC2
GNOMAD BrowserENSG00000120594
Varsome BrowserPLXDC2
ACMGPLXDC2 variants
VarityQ6UX71
Genomic Variants (DGV)PLXDC2 [DGVbeta]
DECIPHERPLXDC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXDC2 
Mutations
ICGC Data PortalPLXDC2 
TCGA Data PortalPLXDC2 
Broad Tumor PortalPLXDC2
OASIS PortalPLXDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLXDC2
Mutations and Diseases : HGMDPLXDC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLXDC2
DgiDB (Drug Gene Interaction Database)PLXDC2
DoCM (Curated mutations)PLXDC2
CIViC (Clinical Interpretations of Variants in Cancer)PLXDC2
Cancer3DPLXDC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606827   
Orphanet
DisGeNETPLXDC2
MedgenPLXDC2
Genetic Testing Registry PLXDC2
NextProtQ6UX71 [Medical]
GENETestsPLXDC2
Target ValidationPLXDC2
Huge Navigator PLXDC2 [HugePedia]
ClinGenPLXDC2
Clinical trials, drugs, therapy
MyCancerGenomePLXDC2
Protein Interactions : CTDPLXDC2
Pharm GKB GenePA134932187
PharosQ6UX71
Clinical trialPLXDC2
Miscellaneous
canSAR (ICR)PLXDC2
HarmonizomePLXDC2
DataMed IndexPLXDC2
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLXDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:48 CEST 2021

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