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PLXDC2 (plexin domain containing 2)

Identity

Alias_symbol (synonym)TEM7R
FLJ14623
Other alias
HGNC (Hugo) PLXDC2
LocusID (NCBI) 84898
Atlas_Id 41753
Location 10p12.31  [Link to chromosome band 10p12]
Location_base_pair Starts at 19816443 and ends at 20289855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN1C (11p15.4) / PLXDC2 (10p12.31)MPHOSPH6 (16q23.3) / PLXDC2 (10p12.31)PLXDC2 (10p12.31) / MALRD1 (10p12.31)
PLXDC2 (10p12.31) / PLXDC2 (10p12.31)PLXDC2 (10p12.31) / ST8SIA6 (10p12.33)PLXDC2 (10p12.31) / SYNE1 (6q25.1)
PLXDC2 (10p12.31) / VAMP5 (2p11.2)SPAG6 (10p12.2) / PLXDC2 (10p12.31)MPHOSPH6 16q23.3 / PLXDC2 10p12.31
PLXDC2 10p12.31 C10orf112PLXDC2 10p12.31 / ST8SIA6 10p12.33PLXDC2 10p12.31 / SYNE1 6q25.1
PLXDC2 10p12.31 / VAMP5 2p11.2SPAG6 10p12.2 / PLXDC2 10p12.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXDC2   21013
Cards
Entrez_Gene (NCBI)PLXDC2  84898  plexin domain containing 2
AliasesTEM7R
GeneCards (Weizmann)PLXDC2
Ensembl hg19 (Hinxton)ENSG00000120594 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120594 [Gene_View]  chr10:19816443-20289855 [Contig_View]  PLXDC2 [Vega]
ICGC DataPortalENSG00000120594
TCGA cBioPortalPLXDC2
AceView (NCBI)PLXDC2
Genatlas (Paris)PLXDC2
WikiGenes84898
SOURCE (Princeton)PLXDC2
Genetics Home Reference (NIH)PLXDC2
Genomic and cartography
GoldenPath hg38 (UCSC)PLXDC2  -     chr10:19816443-20289855 +  10p12.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXDC2  -     10p12.31   [Description]    (hg19-Feb_2009)
EnsemblPLXDC2 - 10p12.31 [CytoView hg19]  PLXDC2 - 10p12.31 [CytoView hg38]
Mapping of homologs : NCBIPLXDC2 [Mapview hg19]  PLXDC2 [Mapview hg38]
OMIM606827   
Gene and transcription
Genbank (Entrez)AF378757 AI311457 AK027529 AK127644 AK304591
RefSeq transcript (Entrez)NM_001282736 NM_032812
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLXDC2
Cluster EST : UnigeneHs.733859 [ NCBI ]
CGAP (NCI)Hs.733859
Alternative Splicing GalleryENSG00000120594
Gene ExpressionPLXDC2 [ NCBI-GEO ]   PLXDC2 [ EBI - ARRAY_EXPRESS ]   PLXDC2 [ SEEK ]   PLXDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXDC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84898
GTEX Portal (Tissue expression)PLXDC2
Human Protein AtlasENSG00000120594-PLXDC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UX71   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UX71  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UX71
Splice isoforms : SwissVarQ6UX71
PhosPhoSitePlusQ6UX71
Domains : Interpro (EBI)Plexin_repeat    PLXDC    PLXDC2    PSI   
Domain families : Pfam (Sanger)PSI (PF01437)   
Domain families : Pfam (NCBI)pfam01437   
Domain families : Smart (EMBL)PSI (SM00423)  
Conserved Domain (NCBI)PLXDC2
DMDM Disease mutations84898
Blocks (Seattle)PLXDC2
SuperfamilyQ6UX71
Human Protein Atlas [tissue]ENSG00000120594-PLXDC2 [tissue]
Peptide AtlasQ6UX71
HPRD08440
IPIIPI00044369   IPI00073777   IPI00640599   
Protein Interaction databases
DIP (DOE-UCLA)Q6UX71
IntAct (EBI)Q6UX71
FunCoupENSG00000120594
BioGRIDPLXDC2
STRING (EMBL)PLXDC2
ZODIACPLXDC2
Ontologies - Pathways
QuickGOQ6UX71
Ontology : AmiGOprotein binding  integral component of membrane  extracellular exosome  
Ontology : EGO-EBIprotein binding  integral component of membrane  extracellular exosome  
NDEx NetworkPLXDC2
Atlas of Cancer Signalling NetworkPLXDC2
Wikipedia pathwaysPLXDC2
Orthology - Evolution
OrthoDB84898
GeneTree (enSembl)ENSG00000120594
Phylogenetic Trees/Animal Genes : TreeFamPLXDC2
HOVERGENQ6UX71
HOGENOMQ6UX71
Homologs : HomoloGenePLXDC2
Homology/Alignments : Family Browser (UCSC)PLXDC2
Gene fusions - Rearrangements
Fusion : MitelmanMPHOSPH6/PLXDC2 [16q23.3/10p12.31]  [t(10;16)(p12;q23)]  
Fusion : MitelmanPLXDC2/MALRD1 [10p12.31/10p12.31]  [t(10;10)(p12;p12)]  
Fusion : MitelmanPLXDC2/ST8SIA6 [10p12.31/10p12.33]  [t(10;10)(p12;p12)]  
Fusion : MitelmanPLXDC2/SYNE1 [10p12.31/6q25.1]  [t(6;10)(q25;p12)]  
Fusion : MitelmanPLXDC2/VAMP5 [10p12.31/2p11.2]  [t(2;10)(p11;p12)]  
Fusion : MitelmanSPAG6/PLXDC2 [10p12.2/10p12.31]  [t(10;10)(p12;p12)]  
Fusion: TCGA_MDACCMPHOSPH6 16q23.3 PLXDC2 10p12.31 SKCM
Fusion: TCGA_MDACCPLXDC2 10p12.31 C10orf112 LGG
Fusion: TCGA_MDACCPLXDC2 10p12.31 ST8SIA6 10p12.33 BRCA
Fusion: TCGA_MDACCPLXDC2 10p12.31 SYNE1 6q25.1 BRCA
Fusion: TCGA_MDACCPLXDC2 10p12.31 VAMP5 2p11.2 BLCA
Fusion: TCGA_MDACCSPAG6 10p12.2 PLXDC2 10p12.31 BLCA
Tumor Fusion PortalPLXDC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXDC2
dbVarPLXDC2
ClinVarPLXDC2
1000_GenomesPLXDC2 
Exome Variant ServerPLXDC2
ExAC (Exome Aggregation Consortium)ENSG00000120594
GNOMAD BrowserENSG00000120594
Genetic variants : HAPMAP84898
Genomic Variants (DGV)PLXDC2 [DGVbeta]
DECIPHERPLXDC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXDC2 
Mutations
ICGC Data PortalPLXDC2 
TCGA Data PortalPLXDC2 
Broad Tumor PortalPLXDC2
OASIS PortalPLXDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXDC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXDC2
DgiDB (Drug Gene Interaction Database)PLXDC2
DoCM (Curated mutations)PLXDC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXDC2 (select a term)
intoGenPLXDC2
Cancer3DPLXDC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606827   
Orphanet
DisGeNETPLXDC2
MedgenPLXDC2
Genetic Testing Registry PLXDC2
NextProtQ6UX71 [Medical]
TSGene84898
GENETestsPLXDC2
Target ValidationPLXDC2
Huge Navigator PLXDC2 [HugePedia]
snp3D : Map Gene to Disease84898
BioCentury BCIQPLXDC2
ClinGenPLXDC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84898
Chemical/Pharm GKB GenePA134932187
Clinical trialPLXDC2
Miscellaneous
canSAR (ICR)PLXDC2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXDC2
EVEXPLXDC2
GoPubMedPLXDC2
iHOPPLXDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:16 CET 2017

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