Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PLXNA1 (plexin A1)

Identity

Alias_namesPLXN1
Alias_symbol (synonym)NOV
Other aliasNOVP
PLEXIN-A1
HGNC (Hugo) PLXNA1
LocusID (NCBI) 5361
Atlas_Id 45685
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 126988594 and ends at 127037392 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGF2 (11p15.5) / PLXNA1 (3q21.3)PLXNA1 (3q21.3) / C19orf81 (19q13.33)PLXNA1 (3q21.3) / CHCHD6 (3q21.3)
PLXNA1 (3q21.3) / CPNE4 (3q22.1)PLXNA1 (3q21.3) / CTSD (11p15.5)PLXNA1 (3q21.3) / DZIP1L (3q22.3)
PLXNA1 3q21.3 / CHCHD6 3q21.3PLXNA1 3q21.3 / DZIP1L 3q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  PLXNA1/CHCHD6 (3q21)
t(3;3)(q21;q22) PLXNA1/CPNE4
t(3;3)(q21;q22) PLXNA1/DZIP1L
t(3;11)(q21;p15) PLXNA1/CTSD

External links

Nomenclature
HGNC (Hugo)PLXNA1   9099
Cards
Entrez_Gene (NCBI)PLXNA1  5361  plexin A1
AliasesNOV; NOVP; PLEXIN-A1; PLXN1
GeneCards (Weizmann)PLXNA1
Ensembl hg19 (Hinxton)ENSG00000114554 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114554 [Gene_View]  ENSG00000114554 [Sequence]  chr3:126988594-127037392 [Contig_View]  PLXNA1 [Vega]
ICGC DataPortalENSG00000114554
TCGA cBioPortalPLXNA1
AceView (NCBI)PLXNA1
Genatlas (Paris)PLXNA1
WikiGenes5361
SOURCE (Princeton)PLXNA1
Genetics Home Reference (NIH)PLXNA1
Genomic and cartography
GoldenPath hg38 (UCSC)PLXNA1  -     chr3:126988594-127037392 +  3q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXNA1  -     3q21.3   [Description]    (hg19-Feb_2009)
EnsemblPLXNA1 - 3q21.3 [CytoView hg19]  PLXNA1 - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBIPLXNA1 [Mapview hg19]  PLXNA1 [Mapview hg38]
OMIM601055   
Gene and transcription
Genbank (Entrez)AI472001 AK054675 AK055605 AK126101 AK127254
RefSeq transcript (Entrez)NM_032242
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLXNA1
Cluster EST : UnigeneHs.432329 [ NCBI ]
CGAP (NCI)Hs.432329
Alternative Splicing GalleryENSG00000114554
Gene ExpressionPLXNA1 [ NCBI-GEO ]   PLXNA1 [ EBI - ARRAY_EXPRESS ]   PLXNA1 [ SEEK ]   PLXNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5361
GTEX Portal (Tissue expression)PLXNA1
Human Protein AtlasENSG00000114554-PLXNA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UIW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UIW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UIW2
Splice isoforms : SwissVarQ9UIW2
PhosPhoSitePlusQ9UIW2
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT_dom    Plexin    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    PSI    Rho_GTPase_activation_prot    Semap_dom    Semap_dom_sf    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNA1
DMDM Disease mutations5361
Blocks (Seattle)PLXNA1
SuperfamilyQ9UIW2
Human Protein Atlas [tissue]ENSG00000114554-PLXNA1 [tissue]
Peptide AtlasQ9UIW2
HPRD11868
IPIIPI00552671   IPI00871326   IPI00749037   
Protein Interaction databases
DIP (DOE-UCLA)Q9UIW2
IntAct (EBI)Q9UIW2
FunCoupENSG00000114554
BioGRIDPLXNA1
STRING (EMBL)PLXNA1
ZODIACPLXNA1
Ontologies - Pathways
QuickGOQ9UIW2
Ontology : AmiGOsemaphorin receptor complex  semaphorin receptor complex  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  multicellular organism development  regulation of cell shape  regulation of smooth muscle cell migration  semaphorin receptor activity  semaphorin receptor activity  regulation of cell migration  signaling receptor activity  regulation of GTPase activity  positive regulation of axonogenesis  dichotomous subdivision of terminal units involved in salivary gland branching  extracellular exosome  semaphorin-plexin signaling pathway involved in axon guidance  neuron projection extension  
Ontology : EGO-EBIsemaphorin receptor complex  semaphorin receptor complex  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  multicellular organism development  regulation of cell shape  regulation of smooth muscle cell migration  semaphorin receptor activity  semaphorin receptor activity  regulation of cell migration  signaling receptor activity  regulation of GTPase activity  positive regulation of axonogenesis  dichotomous subdivision of terminal units involved in salivary gland branching  extracellular exosome  semaphorin-plexin signaling pathway involved in axon guidance  neuron projection extension  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNA1
Atlas of Cancer Signalling NetworkPLXNA1
Wikipedia pathwaysPLXNA1
Orthology - Evolution
OrthoDB5361
GeneTree (enSembl)ENSG00000114554
Phylogenetic Trees/Animal Genes : TreeFamPLXNA1
HOVERGENQ9UIW2
HOGENOMQ9UIW2
Homologs : HomoloGenePLXNA1
Homology/Alignments : Family Browser (UCSC)PLXNA1
Gene fusions - Rearrangements
Fusion : MitelmanPLXNA1/CHCHD6 [3q21.3/3q21.3]  
Fusion : MitelmanPLXNA1/CPNE4 [3q21.3/3q22.1]  [t(3;3)(q21;q22)]  
Fusion : MitelmanPLXNA1/CTSD [3q21.3/11p15.5]  [t(3;11)(q21;p15)]  
Fusion : MitelmanPLXNA1/DZIP1L [3q21.3/3q22.3]  [t(3;3)(q21;q22)]  
Fusion PortalPLXNA1 3q21.3 CHCHD6 3q21.3 BLCA PRAD
Fusion PortalPLXNA1 3q21.3 DZIP1L 3q22.3 PRAD
Fusion : QuiverPLXNA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNA1
dbVarPLXNA1
ClinVarPLXNA1
1000_GenomesPLXNA1 
Exome Variant ServerPLXNA1
ExAC (Exome Aggregation Consortium)ENSG00000114554
GNOMAD BrowserENSG00000114554
Varsome BrowserPLXNA1
Genetic variants : HAPMAP5361
Genomic Variants (DGV)PLXNA1 [DGVbeta]
DECIPHERPLXNA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXNA1 
Mutations
ICGC Data PortalPLXNA1 
TCGA Data PortalPLXNA1 
Broad Tumor PortalPLXNA1
OASIS PortalPLXNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNA1
intOGen PortalPLXNA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXNA1
DgiDB (Drug Gene Interaction Database)PLXNA1
DoCM (Curated mutations)PLXNA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNA1 (select a term)
intoGenPLXNA1
Cancer3DPLXNA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601055   
Orphanet
DisGeNETPLXNA1
MedgenPLXNA1
Genetic Testing Registry PLXNA1
NextProtQ9UIW2 [Medical]
TSGene5361
GENETestsPLXNA1
Target ValidationPLXNA1
Huge Navigator PLXNA1 [HugePedia]
snp3D : Map Gene to Disease5361
BioCentury BCIQPLXNA1
ClinGenPLXNA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5361
Chemical/Pharm GKB GenePA33425
Clinical trialPLXNA1
Miscellaneous
canSAR (ICR)PLXNA1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNA1
EVEXPLXNA1
GoPubMedPLXNA1
iHOPPLXNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:30:45 CET 2018
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