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PLXNA2 (plexin A2)

Identity

Alias_namesPLXN2
Alias_symbol (synonym)OCT
FLJ11751
FLJ30634
KIAA0463
Other alias
HGNC (Hugo) PLXNA2
LocusID (NCBI) 5362
Atlas_Id 51531
Location 1q32.2  [Link to chromosome band 1q32]
Location_base_pair Starts at 208022243 and ends at 208244320 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC42BPA (1q42.13) / PLXNA2 (1q32.2)DDX27 (20q13.13) / PLXNA2 (1q32.2)DYNC1LI2 (16q22.1) / PLXNA2 (1q32.2)
HUWE1 (Xp11.22) / PLXNA2 (1q32.2)PLXNA2 (1q32.2) / DUSP10 (1q41)PLXNA2 (1q32.2) / PLXNA2 (1q32.2)
PLXNA2 (1q32.2) / RAB5B (12q13.2)PLXNA2 (1q32.2) / TMEM50A (1p36.11)PLXNA2 1q32.2 / DUSP10 1q41

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXNA2   9100
Cards
Entrez_Gene (NCBI)PLXNA2  5362  plexin A2
AliasesOCT; PLXN2
GeneCards (Weizmann)PLXNA2
Ensembl hg19 (Hinxton)ENSG00000076356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076356 [Gene_View]  chr1:208022243-208244320 [Contig_View]  PLXNA2 [Vega]
ICGC DataPortalENSG00000076356
TCGA cBioPortalPLXNA2
AceView (NCBI)PLXNA2
Genatlas (Paris)PLXNA2
WikiGenes5362
SOURCE (Princeton)PLXNA2
Genetics Home Reference (NIH)PLXNA2
Genomic and cartography
GoldenPath hg38 (UCSC)PLXNA2  -     chr1:208022243-208244320 -  1q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXNA2  -     1q32.2   [Description]    (hg19-Feb_2009)
EnsemblPLXNA2 - 1q32.2 [CytoView hg19]  PLXNA2 - 1q32.2 [CytoView hg38]
Mapping of homologs : NCBIPLXNA2 [Mapview hg19]  PLXNA2 [Mapview hg38]
OMIM601054   
Gene and transcription
Genbank (Entrez)AB007932 AK021813 AK055196 AK094259 AK094367
RefSeq transcript (Entrez)NM_025179
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLXNA2
Cluster EST : UnigeneHs.497626 [ NCBI ]
CGAP (NCI)Hs.497626
Alternative Splicing GalleryENSG00000076356
Gene ExpressionPLXNA2 [ NCBI-GEO ]   PLXNA2 [ EBI - ARRAY_EXPRESS ]   PLXNA2 [ SEEK ]   PLXNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5362
GTEX Portal (Tissue expression)PLXNA2
Human Protein AtlasENSG00000076356-PLXNA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75051   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75051  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75051
Splice isoforms : SwissVarO75051
PhosPhoSitePlusO75051
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    Plexin    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    PSI    Rho_GTPase_activation_prot    Semap_dom    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNA2
DMDM Disease mutations5362
Blocks (Seattle)PLXNA2
PDB (SRS)3Q3J   
PDB (PDBSum)3Q3J   
PDB (IMB)3Q3J   
PDB (RSDB)3Q3J   
Structural Biology KnowledgeBase3Q3J   
SCOP (Structural Classification of Proteins)3Q3J   
CATH (Classification of proteins structures)3Q3J   
SuperfamilyO75051
Human Protein Atlas [tissue]ENSG00000076356-PLXNA2 [tissue]
Peptide AtlasO75051
HPRD03033
IPIIPI00747751   IPI00061079   IPI00445370   IPI00872947   
Protein Interaction databases
DIP (DOE-UCLA)O75051
IntAct (EBI)O75051
FunCoupENSG00000076356
BioGRIDPLXNA2
STRING (EMBL)PLXNA2
ZODIACPLXNA2
Ontologies - Pathways
QuickGOO75051
Ontology : AmiGOsomitogenesis  semaphorin receptor complex  protein binding  plasma membrane  integral component of plasma membrane  semaphorin receptor activity  branchiomotor neuron axon guidance  neural tube development  cerebellar granule cell precursor tangential migration  regulation of cell migration  regulation of axon extension involved in axon guidance  centrosome localization  pharyngeal system development  limb bud formation  semaphorin-plexin signaling pathway  
Ontology : EGO-EBIsomitogenesis  semaphorin receptor complex  protein binding  plasma membrane  integral component of plasma membrane  semaphorin receptor activity  branchiomotor neuron axon guidance  neural tube development  cerebellar granule cell precursor tangential migration  regulation of cell migration  regulation of axon extension involved in axon guidance  centrosome localization  pharyngeal system development  limb bud formation  semaphorin-plexin signaling pathway  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNA2
Atlas of Cancer Signalling NetworkPLXNA2
Wikipedia pathwaysPLXNA2
Orthology - Evolution
OrthoDB5362
GeneTree (enSembl)ENSG00000076356
Phylogenetic Trees/Animal Genes : TreeFamPLXNA2
HOVERGENO75051
HOGENOMO75051
Homologs : HomoloGenePLXNA2
Homology/Alignments : Family Browser (UCSC)PLXNA2
Gene fusions - Rearrangements
Fusion : MitelmanPLXNA2/DUSP10 [1q32.2/1q41]  
Fusion: TCGA_MDACCPLXNA2 1q32.2 DUSP10 1q41 BRCA
Tumor Fusion PortalPLXNA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNA2
dbVarPLXNA2
ClinVarPLXNA2
1000_GenomesPLXNA2 
Exome Variant ServerPLXNA2
ExAC (Exome Aggregation Consortium)ENSG00000076356
GNOMAD BrowserENSG00000076356
Genetic variants : HAPMAP5362
Genomic Variants (DGV)PLXNA2 [DGVbeta]
DECIPHERPLXNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXNA2 
Mutations
ICGC Data PortalPLXNA2 
TCGA Data PortalPLXNA2 
Broad Tumor PortalPLXNA2
OASIS PortalPLXNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXNA2
DgiDB (Drug Gene Interaction Database)PLXNA2
DoCM (Curated mutations)PLXNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNA2 (select a term)
intoGenPLXNA2
Cancer3DPLXNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601054   
Orphanet
DisGeNETPLXNA2
MedgenPLXNA2
Genetic Testing Registry PLXNA2
NextProtO75051 [Medical]
TSGene5362
GENETestsPLXNA2
Target ValidationPLXNA2
Huge Navigator PLXNA2 [HugePedia]
snp3D : Map Gene to Disease5362
BioCentury BCIQPLXNA2
ClinGenPLXNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5362
Chemical/Pharm GKB GenePA33426
Clinical trialPLXNA2
Miscellaneous
canSAR (ICR)PLXNA2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNA2
EVEXPLXNA2
GoPubMedPLXNA2
iHOPPLXNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 20:52:49 CET 2017

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