PLXNA2 (plexin A2)

2010-06-01  

Identity

HGNC
PLXNA2
LOCATION
1q32.2
LOCUSID
5362
ALIAS
OCT,PLXN2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5362
MIM: 601054
HGNC: 9100
Ensembl: ENSG00000076356

Variants:

dbSNP: 5362
ClinVar: 5362
TCGA: ENSG00000076356
COSMIC: PLXNA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076356ENST00000367033O75051

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
229125872012Rare copy number variations in adults with tetralogy of Fallot implicate novel risk gene pathways.61
196665192009GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.55
164021342006Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia.42
164021342006Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia.42
204552462010Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.38
194808422009Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.33
237086572014Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2.22
173395202007Anxiety and comorbid measures associated with PLXNA2.17

Citation

Dessen P

PLXNA2 (plexin A2)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51531/plxna2