Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLXNA3 (plexin A3)

Identity

Alias_namesPLXN4
Alias_symbol (synonym)SEX
XAP-6
6.3
Plxn3
Other aliasHSSEXGENE
PLXN3
HGNC (Hugo) PLXNA3
LocusID (NCBI) 55558
Atlas_Id 52529
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 153686621 and ends at 153701989 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PLXNA3 (Xq28) / TKTL1 (Xq28)PLXNA3 Xq28 / TKTL1 Xq28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXNA3   9101
Cards
Entrez_Gene (NCBI)PLXNA3  55558  plexin A3
Aliases6.3; HSSEXGENE; PLXN3; PLXN4; 
XAP-6
GeneCards (Weizmann)PLXNA3
Ensembl hg19 (Hinxton)ENSG00000130827 [Gene_View]  chrX:153686621-153701989 [Contig_View]  PLXNA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130827 [Gene_View]  chrX:153686621-153701989 [Contig_View]  PLXNA3 [Vega]
ICGC DataPortalENSG00000130827
TCGA cBioPortalPLXNA3
AceView (NCBI)PLXNA3
Genatlas (Paris)PLXNA3
WikiGenes55558
SOURCE (Princeton)PLXNA3
Genetics Home Reference (NIH)PLXNA3
Genomic and cartography
GoldenPath hg19 (UCSC)PLXNA3  -     chrX:153686621-153701989 +  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLXNA3  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblPLXNA3 - Xq28 [CytoView hg19]  PLXNA3 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIPLXNA3 [Mapview hg19]  PLXNA3 [Mapview hg38]
OMIM300022   
Gene and transcription
Genbank (Entrez)AW001914 BC156373 BC172494 BF798844 BG820285
RefSeq transcript (Entrez)NM_017514
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_021298 NT_011681 NW_004929448
Consensus coding sequences : CCDS (NCBI)PLXNA3
Cluster EST : UnigeneHs.632839 [ NCBI ]
CGAP (NCI)Hs.632839
Alternative Splicing GalleryENSG00000130827
Gene ExpressionPLXNA3 [ NCBI-GEO ]   PLXNA3 [ EBI - ARRAY_EXPRESS ]   PLXNA3 [ SEEK ]   PLXNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55558
GTEX Portal (Tissue expression)PLXNA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51805   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51805  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51805
Splice isoforms : SwissVarP51805
PhosPhoSitePlusP51805
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    Plexin    Plexin-like_fold    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    Rho_GTPase_activation_prot    Semap_dom    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNA3
DMDM Disease mutations55558
Blocks (Seattle)PLXNA3
SuperfamilyP51805
Human Protein AtlasENSG00000130827
Peptide AtlasP51805
HPRD02062
IPIIPI00020884   
Protein Interaction databases
DIP (DOE-UCLA)P51805
IntAct (EBI)P51805
FunCoupENSG00000130827
BioGRIDPLXNA3
STRING (EMBL)PLXNA3
ZODIACPLXNA3
Ontologies - Pathways
QuickGOP51805
Ontology : AmiGOsemaphorin receptor complex  transmembrane signaling receptor activity  protein binding  nucleus  plasma membrane  plasma membrane  integral component of plasma membrane  multicellular organism development  membrane  semaphorin receptor activity  facial nerve structural organization  trigeminal nerve structural organization  hippocampus development  branchiomotor neuron axon guidance  pyramidal neuron development  cell junction  regulation of cell migration  intracellular membrane-bounded organelle  regulation of axon extension involved in axon guidance  negative regulation of axon extension involved in axon guidance  negative chemotaxis  positive regulation of cytoskeleton organization  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  neuron projection extension  
Ontology : EGO-EBIsemaphorin receptor complex  transmembrane signaling receptor activity  protein binding  nucleus  plasma membrane  plasma membrane  integral component of plasma membrane  multicellular organism development  membrane  semaphorin receptor activity  facial nerve structural organization  trigeminal nerve structural organization  hippocampus development  branchiomotor neuron axon guidance  pyramidal neuron development  cell junction  regulation of cell migration  intracellular membrane-bounded organelle  regulation of axon extension involved in axon guidance  negative regulation of axon extension involved in axon guidance  negative chemotaxis  positive regulation of cytoskeleton organization  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  neuron projection extension  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNA3
Atlas of Cancer Signalling NetworkPLXNA3
Wikipedia pathwaysPLXNA3
Orthology - Evolution
OrthoDB55558
GeneTree (enSembl)ENSG00000130827
Phylogenetic Trees/Animal Genes : TreeFamPLXNA3
HOVERGENP51805
HOGENOMP51805
Homologs : HomoloGenePLXNA3
Homology/Alignments : Family Browser (UCSC)PLXNA3
Gene fusions - Rearrangements
Fusion: TCGAPLXNA3 Xq28 TKTL1 Xq28 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNA3
dbVarPLXNA3
ClinVarPLXNA3
1000_GenomesPLXNA3 
Exome Variant ServerPLXNA3
ExAC (Exome Aggregation Consortium)PLXNA3 (select the gene name)
Genetic variants : HAPMAP55558
Genomic Variants (DGV)PLXNA3 [DGVbeta]
DECIPHER (Syndromes)X:153686621-153701989  ENSG00000130827
CONAN: Copy Number AnalysisPLXNA3 
Mutations
ICGC Data PortalPLXNA3 
TCGA Data PortalPLXNA3 
Broad Tumor PortalPLXNA3
OASIS PortalPLXNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch PLXNA3
DgiDB (Drug Gene Interaction Database)PLXNA3
DoCM (Curated mutations)PLXNA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNA3 (select a term)
intoGenPLXNA3
Cancer3DPLXNA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300022   
Orphanet
MedgenPLXNA3
Genetic Testing Registry PLXNA3
NextProtP51805 [Medical]
TSGene55558
GENETestsPLXNA3
Huge Navigator PLXNA3 [HugePedia]
snp3D : Map Gene to Disease55558
BioCentury BCIQPLXNA3
ClinGenPLXNA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55558
Chemical/Pharm GKB GenePA33427
Clinical trialPLXNA3
Miscellaneous
canSAR (ICR)PLXNA3 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNA3
EVEXPLXNA3
GoPubMedPLXNA3
iHOPPLXNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:47 CEST 2017

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