Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLXNA4 (plexin A4)

Identity

Alias_namesPLXNA4A
PLXNA4B
plexin A4, A
plexin A4, B
Alias_symbol (synonym)KIAA1550
DKFZp434G0625PRO34003
FAYV2820
Other aliasPLEXA4
PRO34003
HGNC (Hugo) PLXNA4
LocusID (NCBI) 91584
Atlas_Id 52503
Location 7q32.3  [Link to chromosome band 7q32]
Location_base_pair Starts at 132484762 and ends at 132648688 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGFBP7 (4q12) / PLXNA4 (7q32.3)PLXNA4 (7q32.3) / IFNGR2 (21q22.11)PLXNA4 (7q32.3) / NCKAP5 (2q21.2)
PLXNA4 (7q32.3) / SCAND1 (20q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXNA4   9102
Cards
Entrez_Gene (NCBI)PLXNA4  91584  plexin A4
AliasesFAYV2820; PLEXA4; PLXNA4A; PLXNA4B; 
PRO34003
GeneCards (Weizmann)PLXNA4
Ensembl hg19 (Hinxton)ENSG00000221866 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221866 [Gene_View]  ENSG00000221866 [Sequence]  chr7:132484762-132648688 [Contig_View]  PLXNA4 [Vega]
ICGC DataPortalENSG00000221866
TCGA cBioPortalPLXNA4
AceView (NCBI)PLXNA4
Genatlas (Paris)PLXNA4
WikiGenes91584
SOURCE (Princeton)PLXNA4
Genetics Home Reference (NIH)PLXNA4
Genomic and cartography
GoldenPath hg38 (UCSC)PLXNA4  -     chr7:132484762-132648688 -  7q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXNA4  -     7q32.3   [Description]    (hg19-Feb_2009)
EnsemblPLXNA4 - 7q32.3 [CytoView hg19]  PLXNA4 - 7q32.3 [CytoView hg38]
Mapping of homologs : NCBIPLXNA4 [Mapview hg19]  PLXNA4 [Mapview hg38]
OMIM604280   
Gene and transcription
Genbank (Entrez)AA253415 AB046770 AK055487 AK057743 AK091538
RefSeq transcript (Entrez)NM_001105543 NM_020911 NM_181775
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLXNA4
Cluster EST : UnigeneHs.511454 [ NCBI ]
CGAP (NCI)Hs.511454
Alternative Splicing GalleryENSG00000221866
Gene ExpressionPLXNA4 [ NCBI-GEO ]   PLXNA4 [ EBI - ARRAY_EXPRESS ]   PLXNA4 [ SEEK ]   PLXNA4 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91584
GTEX Portal (Tissue expression)PLXNA4
Human Protein AtlasENSG00000221866-PLXNA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCM2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCM2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCM2
Splice isoforms : SwissVarQ9HCM2
PhosPhoSitePlusQ9HCM2
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT_dom    Plexin    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    PSI    Rho_GTPase_activation_prot    Semap_dom    Semap_dom_sf    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNA4
DMDM Disease mutations91584
Blocks (Seattle)PLXNA4
PDB (SRS)4E+74   
PDB (PDBSum)4E+74   
PDB (IMB)4E+74   
PDB (RSDB)4E+74   
Structural Biology KnowledgeBase4E+74   
SCOP (Structural Classification of Proteins)4E+74   
CATH (Classification of proteins structures)4E+74   
SuperfamilyQ9HCM2
Human Protein Atlas [tissue]ENSG00000221866-PLXNA4 [tissue]
Peptide AtlasQ9HCM2
HPRD10901
IPIIPI00165931   IPI00446588   IPI00748846   IPI00759587   IPI00847813   IPI00877827   IPI01008749   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCM2
IntAct (EBI)Q9HCM2
FunCoupENSG00000221866
BioGRIDPLXNA4
STRING (EMBL)PLXNA4
ZODIACPLXNA4
Ontologies - Pathways
QuickGOQ9HCM2
Ontology : AmiGOsemaphorin receptor complex  semaphorin receptor complex  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  regulation of cell shape  semaphorin receptor activity  facial nerve structural organization  glossopharyngeal nerve morphogenesis  trigeminal nerve structural organization  vagus nerve morphogenesis  postganglionic parasympathetic fiber development  chemorepulsion of branchiomotor axon  anterior commissure morphogenesis  regulation of cell migration  regulation of GTPase activity  sympathetic nervous system development  regulation of axon extension involved in axon guidance  positive regulation of axonogenesis  regulation of negative chemotaxis  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  
Ontology : EGO-EBIsemaphorin receptor complex  semaphorin receptor complex  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  regulation of cell shape  semaphorin receptor activity  facial nerve structural organization  glossopharyngeal nerve morphogenesis  trigeminal nerve structural organization  vagus nerve morphogenesis  postganglionic parasympathetic fiber development  chemorepulsion of branchiomotor axon  anterior commissure morphogenesis  regulation of cell migration  regulation of GTPase activity  sympathetic nervous system development  regulation of axon extension involved in axon guidance  positive regulation of axonogenesis  regulation of negative chemotaxis  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  
NDEx NetworkPLXNA4
Atlas of Cancer Signalling NetworkPLXNA4
Wikipedia pathwaysPLXNA4
Orthology - Evolution
OrthoDB91584
GeneTree (enSembl)ENSG00000221866
Phylogenetic Trees/Animal Genes : TreeFamPLXNA4
HOVERGENQ9HCM2
HOGENOMQ9HCM2
Homologs : HomoloGenePLXNA4
Homology/Alignments : Family Browser (UCSC)PLXNA4
Gene fusions - Rearrangements
Fusion : QuiverPLXNA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNA4
dbVarPLXNA4
ClinVarPLXNA4
1000_GenomesPLXNA4 
Exome Variant ServerPLXNA4
ExAC (Exome Aggregation Consortium)ENSG00000221866
GNOMAD BrowserENSG00000221866
Varsome BrowserPLXNA4
Genetic variants : HAPMAP91584
Genomic Variants (DGV)PLXNA4 [DGVbeta]
DECIPHERPLXNA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXNA4 
Mutations
ICGC Data PortalPLXNA4 
TCGA Data PortalPLXNA4 
Broad Tumor PortalPLXNA4
OASIS PortalPLXNA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXNA4
DgiDB (Drug Gene Interaction Database)PLXNA4
DoCM (Curated mutations)PLXNA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNA4 (select a term)
intoGenPLXNA4
Cancer3DPLXNA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604280   
Orphanet
DisGeNETPLXNA4
MedgenPLXNA4
Genetic Testing Registry PLXNA4
NextProtQ9HCM2 [Medical]
TSGene91584
GENETestsPLXNA4
Target ValidationPLXNA4
Huge Navigator PLXNA4 [HugePedia]
snp3D : Map Gene to Disease91584
BioCentury BCIQPLXNA4
ClinGenPLXNA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91584
Chemical/Pharm GKB GenePA162399757
Clinical trialPLXNA4
Miscellaneous
canSAR (ICR)PLXNA4 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNA4
EVEXPLXNA4
GoPubMedPLXNA4
iHOPPLXNA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:30:46 CET 2018

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