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PLXNB2 (plexin B2)

Identity

Alias (NCBI)MM1
Nbla00445
PLEXB2
dJ402G11.3
HGNC (Hugo) PLXNB2
HGNC Alias symbMM1
KIAA0315
PLEXB2
LocusID (NCBI) 23654
Atlas_Id 46040
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50274979 and ends at 50307646 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KRT7 (12q13.13) / PLXNB2 (22q13.33)PLXNB2 (22q13.33) / CSNK1E (22q13.1)PLXNB2 (22q13.33) / DLG2 (11q14.1)
PLXNB2 (22q13.33) / KIAA1524 (3q13.13)PLXNB2 (22q13.33) / MERTK (2q13)PLXNB2 (22q13.33) / P4HTM (3p21.31)
PLXNB2 (22q13.33) / PLXNB2 (22q13.33)PLXNB2 (22q13.33) / RBM25 (14q24.2)PLXNB2 (22q13.33) / TRIM25 (17q22)
SHANK3 (22q13.33) / PLXNB2 (22q13.33)TACC1 (8p11.22) / PLXNB2 (22q13.33)PLXNB2 22q13.33 / DLG2 11q14.1
PLXNB2 22q13.33 / P4HTM 3p21.31SHANK3 22q13.33 / PLXNB2 22q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PLXNB2   9104
Cards
Entrez_Gene (NCBI)PLXNB2    plexin B2
AliasesMM1; Nbla00445; PLEXB2; dJ402G11.3
GeneCards (Weizmann)PLXNB2
Ensembl hg19 (Hinxton)ENSG00000196576 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196576 [Gene_View]  ENSG00000196576 [Sequence]  chr22:50274979-50307646 [Contig_View]  PLXNB2 [Vega]
ICGC DataPortalENSG00000196576
TCGA cBioPortalPLXNB2
AceView (NCBI)PLXNB2
Genatlas (Paris)PLXNB2
SOURCE (Princeton)PLXNB2
Genetics Home Reference (NIH)PLXNB2
Genomic and cartography
GoldenPath hg38 (UCSC)PLXNB2  -     chr22:50274979-50307646 -  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLXNB2  -     22q13.33   [Description]    (hg19-Feb_2009)
GoldenPathPLXNB2 - 22q13.33 [CytoView hg19]  PLXNB2 - 22q13.33 [CytoView hg38]
ImmunoBaseENSG00000196576
Genome Data Viewer NCBIPLXNB2 [Mapview hg19]  
OMIM604293   
Gene and transcription
Genbank (Entrez)AB002313 AB075511 AK025415 AK025701 AK056543
RefSeq transcript (Entrez)NM_001376864 NM_001376865 NM_001376866 NM_001376867 NM_001376868 NM_001376869 NM_001376870 NM_001376871 NM_001376872 NM_001376873 NM_001376874 NM_001376875 NM_001376876 NM_001376877 NM_001376878 NM_001376879 NM_001376880 NM_001376881 NM_001376882 NM_001376883 NM_001376884 NM_001376885 NM_001376886 NM_012401
Consensus coding sequences : CCDS (NCBI)PLXNB2
Gene ExpressionPLXNB2 [ NCBI-GEO ]   PLXNB2 [ EBI - ARRAY_EXPRESS ]   PLXNB2 [ SEEK ]   PLXNB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNB2 [ Firebrowse - Broad ]
GenevisibleExpression of PLXNB2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23654
GTEX Portal (Tissue expression)PLXNB2
Human Protein AtlasENSG00000196576-PLXNB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15031   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15031  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15031
PhosPhoSitePlusO15031
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT_dom    Plexin    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    PSI    Rho_GTPase_activation_prot    Semap_dom    Semap_dom_sf    TIG1_plexin    WD40/YVTN_repeat-like_dom_sf   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)    TIG_plexin (PF17960)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833    pfam17960   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNB2
PDB (RSDB)4.00E+71   
PDB Europe4.00E+71   
PDB (PDBSum)4.00E+71   
PDB (IMB)4.00E+71   
Structural Biology KnowledgeBase4.00E+71   
SCOP (Structural Classification of Proteins)4.00E+71   
CATH (Classification of proteins structures)4.00E+71   
SuperfamilyO15031
AlphaFold pdb e-kbO15031   
Human Protein Atlas [tissue]ENSG00000196576-PLXNB2 [tissue]
HPRD05050
Protein Interaction databases
DIP (DOE-UCLA)O15031
IntAct (EBI)O15031
BioGRIDPLXNB2
STRING (EMBL)PLXNB2
ZODIACPLXNB2
Ontologies - Pathways
QuickGOO15031
Ontology : AmiGOneural tube closure  regulation of protein phosphorylation  semaphorin receptor complex  protein binding  integral component of plasma membrane  integral component of plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  negative regulation of cell adhesion  neuroblast proliferation  brain development  regulation of cell shape  regulation of cell shape  cell surface  positive regulation of neuron projection development  semaphorin receptor activity  semaphorin receptor activity  regulation of cell migration  regulation of GTPase activity  regulation of GTPase activity  positive regulation of translation  positive regulation of axonogenesis  extracellular exosome  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  excitatory synapse assembly  regulation of neuron migration  
Ontology : EGO-EBIneural tube closure  regulation of protein phosphorylation  semaphorin receptor complex  protein binding  integral component of plasma membrane  integral component of plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  negative regulation of cell adhesion  neuroblast proliferation  brain development  regulation of cell shape  regulation of cell shape  cell surface  positive regulation of neuron projection development  semaphorin receptor activity  semaphorin receptor activity  regulation of cell migration  regulation of GTPase activity  regulation of GTPase activity  positive regulation of translation  positive regulation of axonogenesis  extracellular exosome  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  excitatory synapse assembly  regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNB2
Atlas of Cancer Signalling NetworkPLXNB2
Wikipedia pathwaysPLXNB2
Orthology - Evolution
OrthoDB23654
GeneTree (enSembl)ENSG00000196576
Phylogenetic Trees/Animal Genes : TreeFamPLXNB2
Homologs : HomoloGenePLXNB2
Homology/Alignments : Family Browser (UCSC)PLXNB2
Gene fusions - Rearrangements
Fusion : MitelmanPLXNB2/DLG2 [22q13.33/11q14.1]  
Fusion : MitelmanPLXNB2/P4HTM [22q13.33/3p21.31]  
Fusion : MitelmanSHANK3/PLXNB2 [22q13.33/22q13.33]  
Fusion : QuiverPLXNB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNB2
dbVarPLXNB2
ClinVarPLXNB2
MonarchPLXNB2
1000_GenomesPLXNB2 
Exome Variant ServerPLXNB2
GNOMAD BrowserENSG00000196576
Varsome BrowserPLXNB2
ACMGPLXNB2 variants
VarityO15031
Genomic Variants (DGV)PLXNB2 [DGVbeta]
DECIPHERPLXNB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLXNB2 
Mutations
ICGC Data PortalPLXNB2 
TCGA Data PortalPLXNB2 
Broad Tumor PortalPLXNB2
OASIS PortalPLXNB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLXNB2
Mutations and Diseases : HGMDPLXNB2
intOGen PortalPLXNB2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPLXNB2
DgiDB (Drug Gene Interaction Database)PLXNB2
DoCM (Curated mutations)PLXNB2
CIViC (Clinical Interpretations of Variants in Cancer)PLXNB2
Cancer3DPLXNB2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604293   
Orphanet
DisGeNETPLXNB2
MedgenPLXNB2
Genetic Testing Registry PLXNB2
NextProtO15031 [Medical]
GENETestsPLXNB2
Target ValidationPLXNB2
Huge Navigator PLXNB2 [HugePedia]
ClinGenPLXNB2
Clinical trials, drugs, therapy
MyCancerGenomePLXNB2
Protein Interactions : CTDPLXNB2
Pharm GKB GenePA33430
PharosO15031
Clinical trialPLXNB2
Miscellaneous
canSAR (ICR)PLXNB2
HarmonizomePLXNB2
DataMed IndexPLXNB2
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPLXNB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:25:49 CEST 2021

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