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PLXNB2 (plexin B2)

Identity

Alias_symbol (synonym)MM1
KIAA0315
PLEXB2
Other aliasNbla00445
dJ402G11.3
HGNC (Hugo) PLXNB2
LocusID (NCBI) 23654
Atlas_Id 46040
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50713408 and ends at 50746001 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KRT7 (12q13.13) / PLXNB2 (22q13.33)PLXNB2 (22q13.33) / CSNK1E (22q13.1)PLXNB2 (22q13.33) / DLG2 (11q14.1)
PLXNB2 (22q13.33) / KIAA1524 (3q13.13)PLXNB2 (22q13.33) / MERTK (2q13)PLXNB2 (22q13.33) / P4HTM (3p21.31)
PLXNB2 (22q13.33) / PLXNB2 (22q13.33)PLXNB2 (22q13.33) / RBM25 (14q24.2)PLXNB2 (22q13.33) / TRIM25 (17q22)
SHANK3 (22q13.33) / PLXNB2 (22q13.33)TACC1 (8p11.22) / PLXNB2 (22q13.33)PLXNB2 22q13.33 / DLG2 11q14.1
PLXNB2 22q13.33 / P4HTM 3p21.31SHANK3 22q13.33 / PLXNB2 22q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXNB2   9104
Cards
Entrez_Gene (NCBI)PLXNB2  23654  plexin B2
AliasesMM1; Nbla00445; PLEXB2; dJ402G11.3
GeneCards (Weizmann)PLXNB2
Ensembl hg19 (Hinxton)ENSG00000196576 [Gene_View]  chr22:50713408-50746001 [Contig_View]  PLXNB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196576 [Gene_View]  chr22:50713408-50746001 [Contig_View]  PLXNB2 [Vega]
ICGC DataPortalENSG00000196576
TCGA cBioPortalPLXNB2
AceView (NCBI)PLXNB2
Genatlas (Paris)PLXNB2
WikiGenes23654
SOURCE (Princeton)PLXNB2
Genetics Home Reference (NIH)PLXNB2
Genomic and cartography
GoldenPath hg19 (UCSC)PLXNB2  -     chr22:50713408-50746001 -  22q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLXNB2  -     22q13.33   [Description]    (hg38-Dec_2013)
EnsemblPLXNB2 - 22q13.33 [CytoView hg19]  PLXNB2 - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIPLXNB2 [Mapview hg19]  PLXNB2 [Mapview hg38]
OMIM604293   
Gene and transcription
Genbank (Entrez)AB002313 AB075511 AK025415 AK025701 AK056543
RefSeq transcript (Entrez)NM_012401
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011526 NW_004929431
Consensus coding sequences : CCDS (NCBI)PLXNB2
Cluster EST : UnigeneHs.736016 [ NCBI ]
CGAP (NCI)Hs.736016
Alternative Splicing GalleryENSG00000196576
Gene ExpressionPLXNB2 [ NCBI-GEO ]   PLXNB2 [ EBI - ARRAY_EXPRESS ]   PLXNB2 [ SEEK ]   PLXNB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23654
GTEX Portal (Tissue expression)PLXNB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15031   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15031  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15031
Splice isoforms : SwissVarO15031
PhosPhoSitePlusO15031
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    Plexin    Plexin-like_fold    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    RasGAP_dom    Rho_GTPase_activation_prot    Semap_dom    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNB2
DMDM Disease mutations23654
Blocks (Seattle)PLXNB2
PDB (SRS)4.00E+71   
PDB (PDBSum)4.00E+71   
PDB (IMB)4.00E+71   
PDB (RSDB)4.00E+71   
Structural Biology KnowledgeBase4.00E+71   
SCOP (Structural Classification of Proteins)4.00E+71   
CATH (Classification of proteins structures)4.00E+71   
SuperfamilyO15031
Human Protein AtlasENSG00000196576
Peptide AtlasO15031
HPRD05050
IPIIPI00853369   IPI00816626   IPI00383422   IPI00852623   IPI00941351   IPI00852734   IPI00852803   IPI00852891   
Protein Interaction databases
DIP (DOE-UCLA)O15031
IntAct (EBI)O15031
FunCoupENSG00000196576
BioGRIDPLXNB2
STRING (EMBL)PLXNB2
ZODIACPLXNB2
Ontologies - Pathways
QuickGOO15031
Ontology : AmiGOneural tube closure  regulation of protein phosphorylation  semaphorin receptor complex  protein binding  integral component of plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  neuroblast proliferation  brain development  regulation of cell shape  regulation of cell shape  cell surface  semaphorin receptor activity  semaphorin receptor activity  regulation of cell migration  regulation of GTPase activity  regulation of GTPase activity  positive regulation of axonogenesis  extracellular exosome  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  regulation of neuron migration  
Ontology : EGO-EBIneural tube closure  regulation of protein phosphorylation  semaphorin receptor complex  protein binding  integral component of plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  neuroblast proliferation  brain development  regulation of cell shape  regulation of cell shape  cell surface  semaphorin receptor activity  semaphorin receptor activity  regulation of cell migration  regulation of GTPase activity  regulation of GTPase activity  positive regulation of axonogenesis  extracellular exosome  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  regulation of neuron migration  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNB2
Atlas of Cancer Signalling NetworkPLXNB2
Wikipedia pathwaysPLXNB2
Orthology - Evolution
OrthoDB23654
GeneTree (enSembl)ENSG00000196576
Phylogenetic Trees/Animal Genes : TreeFamPLXNB2
HOVERGENO15031
HOGENOMO15031
Homologs : HomoloGenePLXNB2
Homology/Alignments : Family Browser (UCSC)PLXNB2
Gene fusions - Rearrangements
Fusion : MitelmanPLXNB2/DLG2 [22q13.33/11q14.1]  
Fusion : MitelmanPLXNB2/P4HTM [22q13.33/3p21.31]  [t(3;22)(p21;q13)]  
Fusion : MitelmanSHANK3/PLXNB2 [22q13.33/22q13.33]  [t(22;22)(q13;q13)]  
Fusion: TCGAPLXNB2 22q13.33 DLG2 11q14.1 BRCA
Fusion: TCGAPLXNB2 22q13.33 P4HTM 3p21.31 PRAD
Fusion: TCGASHANK3 22q13.33 PLXNB2 22q13.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNB2
dbVarPLXNB2
ClinVarPLXNB2
1000_GenomesPLXNB2 
Exome Variant ServerPLXNB2
ExAC (Exome Aggregation Consortium)PLXNB2 (select the gene name)
Genetic variants : HAPMAP23654
Genomic Variants (DGV)PLXNB2 [DGVbeta]
DECIPHER (Syndromes)22:50713408-50746001  ENSG00000196576
CONAN: Copy Number AnalysisPLXNB2 
Mutations
ICGC Data PortalPLXNB2 
TCGA Data PortalPLXNB2 
Broad Tumor PortalPLXNB2
OASIS PortalPLXNB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNB2
intOGen PortalPLXNB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXNB2
DgiDB (Drug Gene Interaction Database)PLXNB2
DoCM (Curated mutations)PLXNB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNB2 (select a term)
intoGenPLXNB2
Cancer3DPLXNB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604293   
Orphanet
MedgenPLXNB2
Genetic Testing Registry PLXNB2
NextProtO15031 [Medical]
TSGene23654
GENETestsPLXNB2
Huge Navigator PLXNB2 [HugePedia]
snp3D : Map Gene to Disease23654
BioCentury BCIQPLXNB2
ClinGenPLXNB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23654
Chemical/Pharm GKB GenePA33430
Clinical trialPLXNB2
Miscellaneous
canSAR (ICR)PLXNB2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNB2
EVEXPLXNB2
GoPubMedPLXNB2
iHOPPLXNB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:47 CEST 2017

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