Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLXNB3 (plexin B3)

Identity

Alias_namesPLXN6
Alias_symbol (synonym)PLEXR
PLEXB3
Other alias
HGNC (Hugo) PLXNB3
LocusID (NCBI) 5365
Atlas_Id 53969
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 153029651 and ends at 153044801 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GPR37L1 (1q32.1) / PLXNB3 (Xq28)ROPN1 (3q21.1) / PLXNB3 (Xq28)SCN2B (11q23.3) / PLXNB3 (Xq28)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXNB3   9105
Cards
Entrez_Gene (NCBI)PLXNB3  5365  plexin B3
AliasesPLEXB3; PLEXR; PLXN6
GeneCards (Weizmann)PLXNB3
Ensembl hg19 (Hinxton)ENSG00000198753 [Gene_View]  chrX:153029651-153044801 [Contig_View]  PLXNB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198753 [Gene_View]  chrX:153029651-153044801 [Contig_View]  PLXNB3 [Vega]
ICGC DataPortalENSG00000198753
TCGA cBioPortalPLXNB3
AceView (NCBI)PLXNB3
Genatlas (Paris)PLXNB3
WikiGenes5365
SOURCE (Princeton)PLXNB3
Genetics Home Reference (NIH)PLXNB3
Genomic and cartography
GoldenPath hg19 (UCSC)PLXNB3  -     chrX:153029651-153044801 +  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLXNB3  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblPLXNB3 - Xq28 [CytoView hg19]  PLXNB3 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIPLXNB3 [Mapview hg19]  PLXNB3 [Mapview hg38]
OMIM300214   
Gene and transcription
Genbank (Entrez)AB033032 AF149019 AK292535 AK295762 AK295849
RefSeq transcript (Entrez)NM_001163257 NM_005393
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_013255 NT_011681 NW_004929448
Consensus coding sequences : CCDS (NCBI)PLXNB3
Cluster EST : UnigeneHs.632833 [ NCBI ]
CGAP (NCI)Hs.632833
Alternative Splicing GalleryENSG00000198753
Gene ExpressionPLXNB3 [ NCBI-GEO ]   PLXNB3 [ EBI - ARRAY_EXPRESS ]   PLXNB3 [ SEEK ]   PLXNB3 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5365
GTEX Portal (Tissue expression)PLXNB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULL4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULL4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULL4
Splice isoforms : SwissVarQ9ULL4
PhosPhoSitePlusQ9ULL4
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    Plexin    Plexin-like_fold    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    Rho_GTPase_activation_prot    Semap_dom    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)PLXNB3
DMDM Disease mutations5365
Blocks (Seattle)PLXNB3
SuperfamilyQ9ULL4
Human Protein AtlasENSG00000198753
Peptide AtlasQ9ULL4
HPRD02198
IPIIPI00155729   IPI01012985   IPI00922535   IPI00921968   IPI00943863   IPI00644785   IPI00641893   IPI00643423   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULL4
IntAct (EBI)Q9ULL4
FunCoupENSG00000198753
BioGRIDPLXNB3
STRING (EMBL)PLXNB3
ZODIACPLXNB3
Ontologies - Pathways
QuickGOQ9ULL4
Ontology : AmiGOpositive regulation of endothelial cell proliferation  semaphorin receptor complex  protein binding  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  regulation of cell shape  negative regulation of lamellipodium assembly  semaphorin receptor activity  protein domain specific binding  negative regulation of cell migration  negative regulation of GTPase activity  positive regulation of axonogenesis  positive chemotaxis  Rho GDP-dissociation inhibitor binding  cell chemotaxis  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  semaphorin receptor complex  protein binding  plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  regulation of cell shape  negative regulation of lamellipodium assembly  semaphorin receptor activity  protein domain specific binding  negative regulation of cell migration  negative regulation of GTPase activity  positive regulation of axonogenesis  positive chemotaxis  Rho GDP-dissociation inhibitor binding  cell chemotaxis  semaphorin-plexin signaling pathway  semaphorin-plexin signaling pathway involved in axon guidance  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNB3
Atlas of Cancer Signalling NetworkPLXNB3
Wikipedia pathwaysPLXNB3
Orthology - Evolution
OrthoDB5365
GeneTree (enSembl)ENSG00000198753
Phylogenetic Trees/Animal Genes : TreeFamPLXNB3
HOVERGENQ9ULL4
HOGENOMQ9ULL4
Homologs : HomoloGenePLXNB3
Homology/Alignments : Family Browser (UCSC)PLXNB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNB3
dbVarPLXNB3
ClinVarPLXNB3
1000_GenomesPLXNB3 
Exome Variant ServerPLXNB3
ExAC (Exome Aggregation Consortium)PLXNB3 (select the gene name)
Genetic variants : HAPMAP5365
Genomic Variants (DGV)PLXNB3 [DGVbeta]
DECIPHER (Syndromes)X:153029651-153044801  ENSG00000198753
CONAN: Copy Number AnalysisPLXNB3 
Mutations
ICGC Data PortalPLXNB3 
TCGA Data PortalPLXNB3 
Broad Tumor PortalPLXNB3
OASIS PortalPLXNB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch PLXNB3
DgiDB (Drug Gene Interaction Database)PLXNB3
DoCM (Curated mutations)PLXNB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNB3 (select a term)
intoGenPLXNB3
Cancer3DPLXNB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300214   
Orphanet
MedgenPLXNB3
Genetic Testing Registry PLXNB3
NextProtQ9ULL4 [Medical]
TSGene5365
GENETestsPLXNB3
Huge Navigator PLXNB3 [HugePedia]
snp3D : Map Gene to Disease5365
BioCentury BCIQPLXNB3
ClinGenPLXNB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5365
Chemical/Pharm GKB GenePA33431
Clinical trialPLXNB3
Miscellaneous
canSAR (ICR)PLXNB3 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNB3
EVEXPLXNB3
GoPubMedPLXNB3
iHOPPLXNB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:47 CEST 2017

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