Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PLXNC1 (plexin C1)

Identity

Alias_symbol (synonym)VESPR
CD232
Other aliasPLXN-C1
HGNC (Hugo) PLXNC1
LocusID (NCBI) 10154
Atlas_Id 50027
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 94542499 and ends at 94701451 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CACNA1H (16p13.3) / PLXNC1 (12q22)KPNA4 (3q25.33) / PLXNC1 (12q22)PLXNC1 (12q22) / TRIO (5p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PLXNC1   9106
Cards
Entrez_Gene (NCBI)PLXNC1  10154  plexin C1
AliasesCD232; PLXN-C1; VESPR
GeneCards (Weizmann)PLXNC1
Ensembl hg19 (Hinxton)ENSG00000136040 [Gene_View]  chr12:94542499-94701451 [Contig_View]  PLXNC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000136040 [Gene_View]  chr12:94542499-94701451 [Contig_View]  PLXNC1 [Vega]
ICGC DataPortalENSG00000136040
TCGA cBioPortalPLXNC1
AceView (NCBI)PLXNC1
Genatlas (Paris)PLXNC1
WikiGenes10154
SOURCE (Princeton)PLXNC1
Genetics Home Reference (NIH)PLXNC1
Genomic and cartography
GoldenPath hg19 (UCSC)PLXNC1  -     chr12:94542499-94701451 +  12q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PLXNC1  -     12q22   [Description]    (hg38-Dec_2013)
EnsemblPLXNC1 - 12q22 [CytoView hg19]  PLXNC1 - 12q22 [CytoView hg38]
Mapping of homologs : NCBIPLXNC1 [Mapview hg19]  PLXNC1 [Mapview hg38]
OMIM604259   
Gene and transcription
Genbank (Entrez)AA609130 AB208934 AF030339 AF035307 AK295226
RefSeq transcript (Entrez)NM_005761
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)PLXNC1
Cluster EST : UnigeneHs.584845 [ NCBI ]
CGAP (NCI)Hs.584845
Alternative Splicing GalleryENSG00000136040
Gene ExpressionPLXNC1 [ NCBI-GEO ]   PLXNC1 [ EBI - ARRAY_EXPRESS ]   PLXNC1 [ SEEK ]   PLXNC1 [ MEM ]
Gene Expression Viewer (FireBrowse)PLXNC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10154
GTEX Portal (Tissue expression)PLXNC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60486   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60486  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60486
Splice isoforms : SwissVarO60486
PhosPhoSitePlusO60486
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    IPT    Plexin    Plexin-like_fold    Plexin_cytoplasmic_RasGAP_dom    Plexin_repeat    Rho_GTPase_activation_prot    Semap_dom    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)Plexin_cytopl (PF08337)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam08337    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  
Conserved Domain (NCBI)PLXNC1
DMDM Disease mutations10154
Blocks (Seattle)PLXNC1
PDB (SRS)3KUZ    3NVN    3NVQ   
PDB (PDBSum)3KUZ    3NVN    3NVQ   
PDB (IMB)3KUZ    3NVN    3NVQ   
PDB (RSDB)3KUZ    3NVN    3NVQ   
Structural Biology KnowledgeBase3KUZ    3NVN    3NVQ   
SCOP (Structural Classification of Proteins)3KUZ    3NVN    3NVQ   
CATH (Classification of proteins structures)3KUZ    3NVN    3NVQ   
SuperfamilyO60486
Human Protein AtlasENSG00000136040
Peptide AtlasO60486
HPRD05036
IPIIPI00024766   IPI01013761   IPI01022569   IPI01020889   IPI01021092   IPI01023035   
Protein Interaction databases
DIP (DOE-UCLA)O60486
IntAct (EBI)O60486
FunCoupENSG00000136040
BioGRIDPLXNC1
STRING (EMBL)PLXNC1
ZODIACPLXNC1
Ontologies - Pathways
QuickGOO60486
Ontology : AmiGOsemaphorin receptor complex  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cell adhesion  membrane  semaphorin receptor activity  branchiomotor neuron axon guidance  regulation of cell migration  regulation of axon extension involved in axon guidance  semaphorin-plexin signaling pathway involved in axon guidance  
Ontology : EGO-EBIsemaphorin receptor complex  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cell adhesion  membrane  semaphorin receptor activity  branchiomotor neuron axon guidance  regulation of cell migration  regulation of axon extension involved in axon guidance  semaphorin-plexin signaling pathway involved in axon guidance  
Pathways : KEGGAxon guidance   
NDEx NetworkPLXNC1
Atlas of Cancer Signalling NetworkPLXNC1
Wikipedia pathwaysPLXNC1
Orthology - Evolution
OrthoDB10154
GeneTree (enSembl)ENSG00000136040
Phylogenetic Trees/Animal Genes : TreeFamPLXNC1
HOVERGENO60486
HOGENOMO60486
Homologs : HomoloGenePLXNC1
Homology/Alignments : Family Browser (UCSC)PLXNC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLXNC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLXNC1
dbVarPLXNC1
ClinVarPLXNC1
1000_GenomesPLXNC1 
Exome Variant ServerPLXNC1
ExAC (Exome Aggregation Consortium)PLXNC1 (select the gene name)
Genetic variants : HAPMAP10154
Genomic Variants (DGV)PLXNC1 [DGVbeta]
DECIPHER (Syndromes)12:94542499-94701451  ENSG00000136040
CONAN: Copy Number AnalysisPLXNC1 
Mutations
ICGC Data PortalPLXNC1 
TCGA Data PortalPLXNC1 
Broad Tumor PortalPLXNC1
OASIS PortalPLXNC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLXNC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPLXNC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLXNC1
DgiDB (Drug Gene Interaction Database)PLXNC1
DoCM (Curated mutations)PLXNC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLXNC1 (select a term)
intoGenPLXNC1
Cancer3DPLXNC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604259   
Orphanet
MedgenPLXNC1
Genetic Testing Registry PLXNC1
NextProtO60486 [Medical]
TSGene10154
GENETestsPLXNC1
Huge Navigator PLXNC1 [HugePedia]
snp3D : Map Gene to Disease10154
BioCentury BCIQPLXNC1
ClinGenPLXNC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10154
Chemical/Pharm GKB GenePA33432
Clinical trialPLXNC1
Miscellaneous
canSAR (ICR)PLXNC1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLXNC1
EVEXPLXNC1
GoPubMedPLXNC1
iHOPPLXNC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:14:48 CEST 2017

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