PMCH (pro-melanin concentrating hormone)

2014-11-01  

Identity

HGNC
LOCATION
12q23.2
LOCUSID
ALIAS
MCH,ppMCH

Other Information

Locus ID:

NCBI: 5367
MIM: 176795
HGNC: 9109
Ensembl: ENSG00000183395

Variants:

dbSNP: 5367
ClinVar: 5367
TCGA: ENSG00000183395
COSMIC: PMCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183395ENST00000329406P20382

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD17541984
PA450688olanzapineChemicalClinicalAnnotationassociatedPD17541984

References

Pubmed IDYearTitleCitations
234629902013Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.76
198935842010Identification of 15 loci influencing height in a Korean population.41
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
186503832008Melanin-concentrating hormone as a mediator of intestinal inflammation.28
184984212008Hypocretin and melanin-concentrating hormone in patients with Huntington disease.24
158709102005Melanin-concentrating hormone enhances sucrose intake.18
128852692003Melanin-concentrating hormone functions in the nervous system: food intake and stress.15
122206612002Human immune cells express ppMCH mRNA and functional MCHR1 receptor.13
176409052007Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone.13
236675822013Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.12

Citation

Dessen P

PMCH (pro-melanin concentrating hormone)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72011/pmch