PMEPA1 (prostate transmembrane protein, androgen induced 1)

2003-02-01  

Identity

HGNC
LOCATION
20q13.31
LOCUSID
ALIAS
STAG1,TMEPAI
FUSION GENES

Other Information

Locus ID:

NCBI: 56937
MIM: 606564
HGNC: 14107
Ensembl: ENSG00000124225

Variants:

dbSNP: 56937
ClinVar: 56937
TCGA: ENSG00000124225
COSMIC: PMEPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124225ENST00000265626Q969W9
ENSG00000124225ENST00000341744Q969W9
ENSG00000124225ENST00000347215Q969W9
ENSG00000124225ENST00000347215Q5JY37
ENSG00000124225ENST00000395814Q969W9
ENSG00000124225ENST00000395816Q969W9
ENSG00000124225ENST00000395819A2A2F5
ENSG00000124225ENST00000414037A2A2F4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788

References

Pubmed IDYearTitleCitations
129075942003PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression.42
126709062003PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer.34
187035142008A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells.33
206106322010Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer.29
236154052013TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways.22
244385572014TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells.17
181747522007A role for DNA methylation in regulating the growth suppressor PMEPA1 gene in prostate cancer.14
246947332014Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer.10
258832222015Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.10
249337032014TMEPAI inhibits TGF-β signaling by promoting lysosome degradation of TGF-β receptor and contributes to lung cancer development.8

Citation

Dessen P

PMEPA1 (prostate transmembrane protein, androgen induced 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42589/pmepa1